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Methodologic issues in studies of mortality following epilepsy: measures, types of studies, sources of cases, cohort effects, and competing risks
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Estimating risk for developing epilepsy A population-based study in Rochester, Minnesota
No full textRecurrence of afebrile status epilepticus in a population-based study in Rochester, Minnesota
No full textRisk of unprovoked seizure following acute symptomatic seizures with and without status epilepticus
No full textESTIMATING RISK FOR DEVELOPING EPILEPSY: A POPULATION-BASED STUDY IN ROCHESTER, MINNESOTA
No full textMortality in the First 30 Days Following Incident Acute Symptomatic Seizures
Full text linkPurpose: Very little is known about short-term
mortality after acute symptomatic seizure. One study found an increased mortality in the first year after acute symptomatic seizure, like mortality following acute symptomatic status
epilepticus.
Methods: We studied mortality in the first 30 days after an acute symptomatic seizure in two cohorts. In Washington Heights, New York City, we reviewed the medical records of all adults aged 20 years and older seen at Columbia Presbyterian Medical Center from January 1, 1990 through December 13, 1994 to identify incident acute symptomatic seizure.
In Rochester, Minnesota, the medical records of all Rochester residents were reviewed to identify incident acute symptomatic seizure from January 1, 1965 through December 31, 1984. Case
fatality (CF) and standardized mortality ratio (SMR) were calculated for deaths in the first 30 days. Results: A total of 323 adults were identified in Washington Heights and 428 in Rochester. The CF was 20% in both cohorts.
CF was greatly increased in the people aged 65 years and older (28.4% in Washington Heights and 40.5% in Rochester) versus younger individuals (17.7% inWashington Heights and 11.2% in
Rochester). In both cohorts, theSMRwas greatly increased overall (102.1 in Washington Heights and 149.4 in Rochester), and separately for males, females, all etiologies except head trauma
in Washington Heights, and younger individuals. In older individuals, the SMR was increased in Washington Heights but not in Rochester.
Conclusion: Acute symptomatic seizures are associated with increased mortality in the first 30 days. It is unknown how seizures contribute to this mortality or whether mortality is due
solely to the underlying medical condition. KeyWords: Acute symptomatic seizure—Mortality
Risk of unprovoked seizure after acute symptomatic seizure: effect of status epilepticus
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Time trends in incidence, mortality, and case-fatality after first episode of status epilepticus
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