202,981 research outputs found
A Model of Photon Cell Killing Based on the Spatio-Temporal Clustering of DNA Damage in Higher Order Chromatin Structures
No full textWe present a new approach to model dose rate effects on cell killing after photon radiation based on the spatio-temporal clustering of DNA double strand breaks (DSBs) within higher order chromatin structures of approximately 1-2 Mbp size, so called giant loops. The main concept of this approach consists of a distinction of two classes of lesions, isolated and clustered DSBs, characterized by the number of double strand breaks induced in a giant loop. We assume a low lethality and fast component of repair for isolated DSBs and a high lethality and slow component of repair for clustered DSBs. With appropriate rates, the temporal transition between the different lesion classes is expressed in terms of five differential equations. These allow formulating the dynamics involved in the competition of damage induction and repair for arbitrary dose rates and fractionation schemes. Final cell survival probabilities are computable with a cell line specific set of three parameters: The lethality for isolated DSBs, the lethality for clustered DSBs and the half-life time of isolated DSBs. By comparison with larger sets of published experimental data it is demonstrated that the model describes the cell line dependent response to treatments using either continuous irradiation at a constant dose rate or to split dose irradiation well. Furthermore, an analytic investigation of the formulation concerning single fraction treatments with constant dose rates in the limiting cases of extremely high or low dose rates is presented. The approach is consistent with the Linear-Quadratic model extended by the Lea-Catcheside factor up to the second moment in dose. Finally, it is shown that the model correctly predicts empirical findings about the dose rate dependence of incidence probabilities for deterministic radiation effects like pneumonitis and the bone marrow syndrome. These findings further support the general concepts on which the approach is based. Copyright: © 2014 Herr et al. Copyright: © 2014 Luksys et al
[archive] Kamagurka en Herr Seele /
No full textFotoarchief Michiel HendryckxCartoonisten en kunstenaarsVPRO, nr 46, 17 nov 1985 t/m 24 nov 1985De foto kan u fysiek raadplegen in de leeszaal. Een scan opvragen is op vraag van de fotograaf niet mogelijk.Hendryckx, MichielBijzondere collectiesKaft : portret van Herr Seele (l) en Kamagurka (r)P 3-5 : interview Kamagurka door Rudy Vandendaele
Eine Mark, Der kleine Herr Friedemann, Novellen von Thomas Mann, Fischers Romanbibliothek, In Leinen M. 1.25
No full textEINE MARK, DER KLEINE HERR FRIEDEMANN, NOVELLEN VON THOMAS MANN, FISCHERS ROMANBIBLIOTHEK, IN LEINEN M. 1.25
Eine Mark, Der kleine Herr Friedemann, Novellen von Thomas Mann, Fischers Romanbibliothek, In Leinen M. 1.25 ( -
Parthie Herr Müller
No full textPARTHIE HERR MÜLLER
Dr. Fausts Hauskäppchen oder Die Herberge im Walde : Posse mit Gesang in drei Acten / von Friedr. Hopp. Musik von Kapellmeister M. Hebenstreit (-)
Parthie Herr Müller (20) (1)
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Reden, gehalten bei der Beerdigung des Herrn Ferdinand Gamburg in Frankfurt a. M. am 11. und 15. September 1892
No full textREDEN, GEHALTEN BEI DER BEERDIGUNG DES HERRN FERDINAND GAMBURG IN FRANKFURT A. M. AM 11. UND 15. SEPTEMBER 1892
Reden, gehalten bei der Beerdigung des Herrn Ferdinand Gamburg in Frankfurt a. M. am 11. und 15. September 1892 ( - )
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Reden gehalten bei der Beerdigung des Herrn Ferdinand Gamburg in Frankurt a. M. am 11. September 1892. ( - )
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Rede des Herrn Rabbiner Dr. M. Horovitz ([3])
Herr Dr. Heinemann. (8)
Herr Isaac Benjamin (Cöln). (14)
Herr Leopold Igersheimer. (15)
Herr Dr. Rosenbaum. (16)
Herr Emil Stiebel. (18)
Herr Dr. Abraham Sulzbach. (20)
Trauerreden gehalten in der Frankfurt-Loge XX. No. 372 des U. O. B. B. in Frankfurt a. M. zu Ehren des heimgegangenen Bruders Ferdinand Gamburg am 15. September 1892. (25)
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Präsident Dr. Leo Isaac. (27)
Vicepräsident Dr. Rechstsanwalt Julius Plotke. (28)
Präsident Dr. Leo Isaac. (38)
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Arizona State Museum Archaeological Series No. 192 Vol. 1
No full textThe research setting / Barbara J. Mills -- Climate, vegetation, and dendrochronology / Eric J. Kaldahl, Jeffrey S. Dean -- Silver Creek settlement patterns and paleodemography / Joanne M. Newcombe -- Excavations at three great Kiva sites / Sarah A. Herr, Elizabeth M. Perry, Scott Van Keuren -- Excavations at Pottery Hill / Barbara J. Mills, Sarah A. Herr, Eric J. Kaldahl, Joanne M. Newcombe, Charles R. Riggs, Ruth Van Dyke -- Excavations at Bailey Ruin / Barbara J. Mills, Scott Van Keuren, Susan L. Stinson, William M. Graves, III, Eric J. Kaldahl, Joanne M. Newcomb -- Ceramic ware and type systematics / Barbara J. Mills -- Chronology of the Mogollon Rim Region / Barbara J. Mills, Sarah A. HerrThis title from the ASM Archaeological Series is made available by the Arizona State Museum and University of Arizona Libraries. If you have questions about this title, please contact Jannelle Weakly at the Arizona State Museum, (520) 621-6311, [email protected]
A resonant metamaterial clock distribution network for superconducting logic
No full textWe acknowledge the valuable conversation with O. Naaman regarding the clock network design. H. Dai and J. Egan assisted with the physical design of the clock network and functional circuits. J. Goodman and M. Lateef assisted with the microwave measurement. D. Harvey assisted with the circuit design. This research is based on the work supported in part by the ODNI, IARPA, via ARO, contract no. W911NF-14-C-0116. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the ODNI, IARPA, or the US Government
Debye temperature of nanocrystalline Zr1-xAlx solid solutions with different grain sizes
No full textDebye temperature of nanocrystalline Zr1-xAlx solid solutions with different grain sizes / U. Herr ; M. Geigl and K. Samwer. - In: Philosophical magazine. A. 77. 1998. S. 641-65
Debye temperature of nanocrystalline Zr1-xAlx solid solutions with different grain sizes
No full textDebye temperature of nanocrystalline Zr1-xAlx solid solutions with different grain sizes / U. Herr ; M. Geigl and K. Samwer. - In: Philosophical magazine. A. 77. 1998. S. 641-65
The role of small and medium-sized enterprises in development
No full text[Hansjörg Herr and Zeynep M. Nettekoven]Literaturverzeichnis Seite 35-37Text georgischGeorgisc
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