1,721,226 research outputs found
Hermann-Peter Eberlein (Hg.), Evangelische Kirchengeschichte im Rheinland, Bd. 2: Territorialkirchen und protestantische Kultur: 1648-1800, Bonn 2015
No full textGorißen S. Hermann-Peter Eberlein (Hg.), Evangelische Kirchengeschichte im Rheinland, Bd. 2: Territorialkirchen und protestantische Kultur: 1648-1800, Bonn 2015. Zeitschrift des Bergischen Geschichtsvereins. 2018;104:231-233
Unmet needs of biochemical biomarkers for human prion diseases
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Ministry of Health
10.13039/50110000472
Rapidly progressive dementias — aetiologies, diagnosis and management
No full textRapidly progressive dementias (RPDs) are a group of heterogeneous disorders that include immune-mediated, infectious and metabolic encephalopathies, as well as prion diseases and atypically rapid presentations of more common neurodegenerative diseases. Some of these conditions are treatable, and some must be diagnosed promptly because of their potential infectivity. Prion disease is considered to be the prototypical RPD, but over the past two decades, epidemiological reports and the identification of various encephalitis-mediating antibodies have led to a growing recognition of other encephalopathies as potential causes of rapid cognitive decline. Knowledge of RPD aetiologies, syndromes and diagnostic work-up protocols will help clinicians to establish an early, accurate diagnosis, thereby reducing morbidity and mortality, especially in immune-mediated and other potentially reversible dementias. In this Review, we define the syndrome of RPD and shed light on its different aetiologies and on secondary factors that might contribute to rapid cognitive decline. We describe an extended diagnostic procedure in the context of important differential diagnoses, discuss the utility of biomarkers and summarize potential treatment options. In addition, we discuss treatment options such as high-dose steroid therapy in the context of therapy and diagnosis in clinically ambiguous cases
Verzeichnis sämtlicher Veröffentlichungen 1973-2021 alle namentlich gezeichneten Artikel einschliesslich sog. "Grauer Literatur" und Leserbriefen
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Clinical characteristics and diagnostics of human spongiform encephalopathies: an update
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Genetic prion disease: opportunities for early therapeutic intervention with rigorous pre-symptomatic trials
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