74 research outputs found
A Spinster’s Tour in France, the States of Genoa, etc., during the Year 1827
No full textThe romantic novelist Elizabeth Strutt (1783–c.1863) was ideally suited to the task she set herself when, in 1827, she wrote A Spinster's Tour in France (1828). Although she herself was married, her experiences convinced her of the urgent need for a guidebook designed for the unaccompanied 'lady traveller'. Taking readers through every stage of a long and eventful journey from Southampton to Recco (near Genoa), Strutt combines poetic descriptions of picturesque landscapes with practical advice on lodgings, transport and social interaction. Of particular concern, claims Strutt, is the vulnerability of unchaperoned young women at the hands of 'zealous Roman Catholics' who might seek to convert a 'timid child' to their faith. Strutt's book provides an unusual perspective both on European customs and society, and on the mindset of the British travellers who witnessed them. For more information on this author, see http://orlando.cambridge.org/public/svPeople?person_id=struel</jats:p
Manuscript notes on gold digging and gold licence issued 1858
No full textManuscript notes on gold digging, written around [c.1858] author unknown, may have been George Elliot. Includes on the front page a coloured drawing of 'The Diggings, designed and drawn by William Strutt, and published by D. Urquhart, Collins Street, Melbourne.
William Strutt (1825-1915) was born in Devon, England and studied art in Paris. He arrived in Melbourne on the HMS Culloden, in July 1850. Strutt published engravings in the first issue of the Illustrated Australian Magazine and designed, engraved or lithographed postage stamps, posters, maps, transparencies and seals and began to learn all he could about the history of the colony. His friend and patron John Pasco Fawkner encouraged him to record important colonial events. His works are represented in galleries in Sydney, Melbourne, Ballarat, Adelaide and Hobart. Among European collections, le Musée de Lucerne and the Peace Palace at The Hague hold important paintings. The Dixson and Mitchell libraries, Sydney, the National Library of Australia, State Library and the Parliamentary Library, Victoria, and the Alexander Turnbull Library, Wellington, all hold extensive collections of his sketches, paintings or manuscript material.
Also Gold Licence issued to George Elliot on October 1858 by P.C.. Crespigny, Commissioner. To meet the expense of securing order and to restrain unauthorised mining on Crown land, a local Act of January 1852 imposed on all diggers a licence fee of 30 shillings per month, the penalty for mining without a licence being £6 for the first offence and afterwards imprisonment for terms up to six months
: Presented to The Royal Society of Tasmania by George Elliot.
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Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions
No full textPlanar cell polarity—the organization of cells within a two-dimensional plane—is an important feature in tissue organization. Strutt et al. show that, in the Drosophila wing, endosomal recycling through retromer and its cargo adaptor Snx27 mediates the cell-surface localization of two key planar polarity proteins, Flamingo and Strabismus.</p
EGF Signaling and Ommatidial Rotation in the Drosophila Eye
No full textAbstractThe ommatidia of the Drosophila eye initiate development by stepwise recruitment of photoreceptors into symmetric ommatidial clusters. As they mature, the clusters become asymmetric, adopting opposite chirality on either side of the dorsoventral midline and rotating exactly 90° (Figures 1A and 1B, [1]). The choice of chirality is governed by higher activity of the frizzled (fz) gene in one cell of the R3/R4 photoreceptor pair [2] and by Notch-Delta (N-Dl) signaling [3–5]. The 90° rotation also requires activity of planar polarity genes such as fz as well as the roulette (rlt) locus [2, 6]. We now show that two regulators of EGF signaling, argos and sprouty (sty), and a gain-of-function Ras85D allele, interact genetically with fz in ommatidial polarity. Furthermore, we find that argos is required for ommatidial rotation, but not chirality, and that rlt is a novel allele of argos. We present evidence that there are two pathways by which EGF signaling affects ommatidial rotation. In the first, typified by the rlt phenotype, there is partial transformation of the “mystery cells” toward a neuronal fate. Although most of these mystery cells subsequently fail to develop as neurons, their partial transformation results in inappropriate subcellular localization of the Fz receptor, a likely cue for regulating ommatidial rotation. Secondly, reducing EGF signaling can specifically affect ommatidial rotation without showing transformation of the mystery cells or defects in polarity protein localization
Planar Polarity: Photoreceptors on a High Fat Diet
No full textAbstractDifferential activity of Frizzled in the R3/R4 photo-receptors of Drosophila regulates the orientation of ommatidia. New evidence suggests that the cadherins Dachsous and Fat act upstream of Frizzled in this process
Faculty Opinions recommendation of Disruption of core planar cell polarity signaling regulates renal tubule morphogenesis but is not cystogenic.
No full textPlanar Polarity: Forcing Cells Into Line
No full textSummaryPolarisation of tissues in the plane of an epithelium is fundamental for both animal morphogenesis and organ function. A new paper describes a role for mechanical cues in determining how such polarity is aligned with the body axes
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