7,754 research outputs found
Helen Cox
No full textCigarette card featuring a full body portrait of Helen Cox, with information relating to her role in the Al Christie Comedies on the reverse
Photo of Helen Cox Meyers
No full textA photo of Helen Cox Meyers standing behind the counter in a shop full of ceramic and glassware.Helen Cox Meyer
Photo of Helen Cox Meyers with ceramic statuettes
No full textA photo of Helen Cox Meyers standing in shop displaying ceramic and glassware items.Helen Cox Meyer
Ken Saro-Wiwa in political context: Social movements in the Niger Delta
No full textInternational solidarity between Africa and Ireland
These remarkable letters, from their writing to their publication, trace a history of international solidarity. Their origin lies in the relationship between Ken Saro-Wiwa, the wider Ogoni movement and Majella McCarron’s solidarity work, well-documented in Helen Fallon’s piece above. The letters themselves show Saro-Wiwa in action, mobilizing international support for himself and his co-defendants
The composition of the gut microbiome differs among community dwelling older people with good and poor appetite
No full textBackground: Anorexia of ageing is common and important in the development of sarcopenia in older individuals. Links have been proposed between the gut microbiota and sarcopenia. Disordered gut function is also recognized in anorexia of ageing, but how this may relate to resident gut microbiota is unexplored. Understanding this relationship may provide a basis for novel interventions for anorexia of ageing and sarcopenia. This study explores compositional differences of the gut microbiota between community dwelling healthy older adults with good or poor appetite, and associated differences in sarcopenia. Methods: We assessed appetite by the Simplified Nutritional Appetite Questionnaire (SNAQ) in members of the TwinsUK cohort aged ≥65 years. Using a pool of 776 individuals with existing microbiome data estimated from 16S rRNA sequencing data, we identified 102 cases (SNAQ score < 14) (95% female, mean age 68 years) matched to controls (SNAQ > 14) on body mass index, gender, age, diet, calorie consumption, frailty, antibiotic use, socio-economic status, and technical variables to minimize confounding microbiota associations. Species abundance and diversity, compositional differences, and paired differences in taxa abundance were compared between cases and controls. Additionally, we compared case and controls for sarcopenia as measured by muscle mass (appendicular lean mass/height
2) and strength (chair stand time in seconds). Results: Cases with poor appetite had reduced species richness and diversity of their gut microbiome (adjusted OBSERVED: beta = −0.2, P < 0.001; adjusted SHANNON: beta = −0.17, P = 0.0135), significant compositional differences (adjusted non-parametric multivariate analysis of variance, P = 0.0095), and significant differences in taxa abundance including reduction of genus Lachnospira (logFC = −1.015, q = 0.023). In all-female subgroup analysis, cases with poor appetite demonstrated reduction in muscle strength (11.03 s vs. 9.26 s, P = 0.02). Conclusions: This study is the first to observe differences in the composition of gut microbiota between healthy community dwelling older individuals with good and poor appetite. We found female individuals with reduced muscle strength had poor appetite compared with those with normal strength. These associations require further examination to understand causality and mechanisms of interaction, to inform potential strategies targeting the gut microbiota as a novel intervention for anorexia of ageing and sarcopenia.
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Studies on angiotensin II receptors
No full textThe location of 1251-AII binding sites was investigated in rat intestinal and renal cortex membranes using classical radiolabelled hormone-receptor binding assays. High affinity, specific 125I-AII binding sites were identified in renal cortex crude basolateral and brush-border membranes with a hD of 0.62 t 0.11nM and Bmax of 303.78 t 33.90fmol/mg. In contrast, no specific 1251-AII binding was found with membranes from intestinal epithelia. Specific 125I-AII binding to renal cortex membranes was partially dependent on Ila+, maximal binding being achieved with 130aud Hat Absence of ::aCl reduced steady state binding and increased the rate of ligand dissociation converting a proportion of sites to a lower affinity. Guanine nucleotides directly decreased specific binding with an order of potency; Gpp(IdH)p > GTP >i ITP > GDP > ATP > GI•P > IDP. Gpp(I!H)p reduced steady state binding and decreased ligand dissociation which resulted in an increased binding affinity. 1' I-AII specific binding was sensitive to DTT in a concentration dependent manner. Protection against DTT inactivation was afforded by preincubating membranes with unlabelled AIL The absence of MaUl from preincubations with DTT also reduced the rate of inactivation. Rates of 1251-AII association and dissociation were affected by DTT in a complex manner, converting a proportion of sites to a higher affinity. Guanine nucleotides reduced specific 1251-AII binding synergistically with DTT. These studies have therefore tentatively identified a cation sensitive site in the vicinity of the renal cortex epithelial 1251-AII binding site. Interaction of the former with :Ca+ is proposed to alter the binding site conformation, enabling maximal specific 1251-AII binding and in the absence of labelled hormone, exrosing a disulfide bond to allow a more rapid rate of inactivation by DTT.</p
Interview with Mark Cox
No full textMark Cox is a professor of Creative Writing at UNCW, and has served as Chair of the department. He is the author of three full-length poetry collections: Smoulder, Thirty-Seven Years from the Stone, and Natural Causes
On Campus Video, featuring Abilene (TX) businessman and author Jack Cox.
No full textA videorecording of an interview with Abilene (TX) businessman and author Jack Cox, conducted by Dr. Gary McCaleb of Abilene Christian University
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