21,553 research outputs found
Propofol up2date-Part 2: Patient Groups, unwanted Effects and Sucession Substance Fospropofol
No full textPropofol is a common hypnotic agent in anaesthesiology and intensive care medicine and for procedural sedation as well. Despite the intensive usage the full potential, pharmacokinetic and -dynamic abilities, interactions and side effects of the substance may not be realized by all providers. Additionally there is dispute and unwarranted myth about the substance. Propofol is a highly potent hypnotic with a wide range of (un)desired effects. This article is reviewing the diversity of the substance in clinical practice
Recombinant activated factor VII (Novo7<sup>®</sup>) in patients with ventricular assist devices: Case report and review of the current literature
No full textAbstract Postoperative bleeding might become a serious problem in the management of cardiac surgical patients, with marked medical and economic impact. In these life-threatening situations, massive haemorrhage represents frequently a combination of surgical and coagulopathic bleeding. Surgical bleeding results from a definite source at the operation site and can be corrected using surgical standard techniques. Acute coagulopathies, in contrast, result from impaired thrombin formation, and require optimized therapeutical strategies. Effective pharmacological treatment will be complicated by the presence of ventricular assist devices (VAD), which necessarily imply effective anticoagulation. In episodes of uncontrolled coagulopathic bleeding, the application of recombinant activated factor VII (rFVIIa) as a effective haemostatic agent has become more and more popular. However, only very few data are available on its use in patients with VAD in place. We researched the PubMed-database for case reports about the use of rFVIIa in patients with VAD and summarized them. In addition, we report a case from our hospital. In all cases cessation of bleeding without any thrombembolic complications could be achieved. In cases of uncontrollable, non-surgical bleeding rFVIIa seems to be a therapeutical option even for patients with VAD.</p
Report on Meteorological Research March 1, 1935 (m-1)
No full textThe object of the report was to elucidate in detail the various features of the research program in meteorology being carried on at the Daniel Guggenheim Airship Institute in Akron, Ohio. Mr. L. J. Fangman, of the U.S. Weather Bureau, was collaborating with the author in carrying out work such as a study of autographic records of the various meteorological elements during frontal passages with a view to the possible prediction of the intensity of the accompanying disturbance as it may affect the operation of aircraft and a study of atmospheric gustiness with a view to finding the dependence between frequency end amplitude of velocity fluctuations and the vertical temperature and velocity gradients
Predicting restoration of kidney function during CRRT-free intervals
No full textAbstract Background Renal failure is common in critically ill patients and frequently requires continuous renal replacement therapy (CRRT). CRRT is discontinued at regular intervals for routine changes of the disposable equipment or for replacing clogged filter membrane assemblies. The present study was conducted to determine if the necessity to continue CRRT could be predicted during the CRRT-free period. Materials and methods In the period from 2003 to 2006, 605 patients were treated with CRRT in our ICU. A total of 222 patients with 448 CRRT-free intervals had complete data sets and were used for analysis. Of the total CRRT-free periods, 225 served as an evaluation group. Twenty-nine parameters with an assumed influence on kidney function were analyzed with regard to their potential to predict the restoration of kidney function during the CRRT-free interval. Using univariate analysis and logistic regression, a prospective index was developed and validated in the remaining 223 CRRT-free periods to establish its prognostic strength. Results Only three parameters showed an independent influence on the restoration of kidney function during CRRT-free intervals: the number of previous CRRT cycles (medians in the two outcome groups: 1 vs. 2), the "Sequential Organ Failure Assessment"-score (means in the two outcome groups: 8.3 vs. 9.2) and urinary output after the cessation of CRRT (medians in two outcome groups: 66 ml/h vs. 10 ml/h). The prognostic index, which was calculated from these three variables, showed a satisfactory potential to predict the kidney function during the CRRT-free intervals; Receiver operating characteristic (ROC) analysis revealed an area under the curve of 0.798. Conclusion Restoration of kidney function during CRRT-free periods can be predicted with an index calculated from three variables. Prospective trials in other hospitals must clarify whether our results are generally transferable to other patient populations.</p
Review
No full textPostoperative bleeding might become a serious problem in the management of cardiac surgical patients, with marked medical and economic impact. In these life-threatening situations, massive haemorrhage represents frequently a combination of surgical and coagulopathic bleeding. Surgical bleeding results from a definite source at the operation site and can be corrected using surgical standard techniques. Acute coagulopathies, in contrast, result from impaired thrombin formation, and require optimized therapeutical strategies. Effective pharmacological treatment will be complicated by the presence of ventricular assist devices (VAD), which necessarily imply effective anticoagulation. In episodes of uncontrolled coagulopathic bleeding, the application of recombinant activated factor VII (rFVIIa) as a effective haemostatic agent has become more and more popular. However, only very few data are available on its use in patients with VAD in place. We researched the PubMed-database for case reports about the use of rFVIIa in patients with VAD and summarized them. In addition, we report a case from our hospital. In all cases cessation of bleeding without any thrombembolic complications could be achieved. In cases of uncontrollable, non-surgical bleeding rFVIIa seems to be a therapeutical option even for patients with VAD
(Fourth) Report on Meteorological Activities at the DGAI (8-1-36)(Weather Bureau Copy)
No full textThis report is on the investigations of frontal phenomena at the Daniel Guggenheim Airship Institute in Akron, Ohio from January 1, 1935 through August 1, 1936. The investigation was carried out with the cooperation of the U.S. Bureau of Aeronautics, the U.S. Weather Bureau, the California Institute of Technology, and the Guggenheim Airship Institute. Mr. R.C. Robinson of the Weather Bureau cooperated with the author in carrying out the investigation. The object of the investigation was to determine the intensity of the atmospheric disturbances (i.e. rapidity of wind shift and gustiness) accompanying the passage of cold fronts, along with a study of the characteristics of the air masses involved and other features which might affect the intensity of the disturbance. The report treated thirty cold fronts which passed the station during 1935 to 1936
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