1,541 research outputs found
Fashion and Materiality: Cultural Practices in Global Contexts, ed. by Heike Jenss and Viola Hofmann
No full textEdited by Heike Jenss and Viola Hofmann (London: Bloomsbury Publishing Visual Arts, 2020). 312 pp., 40 b&w illus. £85.00. ISBN: 9781350057814
New interactive graphics tools for exploratory analysis of spatial data
No full textNew interactive graphics tools for exploratory analysis of spatial data / Anthony Unwin and Heike Hofmann. - In: Innovations in GIS 5 / ed. by Steve Carver. - London u.a. : Taylor & Francis, 1998. - S. 46-5
Portrait of Paula Beer Hofmann.
No full textProfile view of the sitter's head.Paula (Pauline) Lissy was born in Vienna, Austria in 1879. In 1897 she married the Austrian Jewish dramatist and poet, Richard Beer-Hofmann. Paula Beer-Hofmann died in Switzerland in 1939.The Austrian painter Hans Schlesinger (1875-1932) was the brother-in-law of the poet and author Hugo von Hofmannsthal.Digital imag
Machine learning in forensic applications
No full textThe 2009 National Academy of Sciences report found pattern‐evidence disciplines to be rife with subjectivity. In the decade since, machine learning methods have been developed to try to address that issue. By Alicia Carriquiry, Heike Hofmann, Xiao Hui Tai and Susan VanderPlas.This following article is published as Carriquiry, Alicia, Heike Hofmann, Xiao Hui Tai, and Susan VanderPlas. "Machine learning in forensic applications." Significance 16, no. 2 (2019): 29-35. Posted with permission of CSAFE.</p
DC-SIGN: Access Portal for Sweet Viral Killers
No full textLozach and colleagues show that phleboviruses (bunyaviridae), which comprise important emerging viral pathogens, exploit the C-type lectin DC-SIGN for dendritic cell binding, entry, and infection. The authors elegantly visualize the cellular processes underlying DC-SIGN-dependent viral capture and uptake
Host Cell Factors in Filovirus Entry: Novel Players, New&#160;Insights
No full textFiloviruses cause severe hemorrhagic fever in humans with high case-fatality rates. The cellular factors exploited by filoviruses for their spread constitute potential targets for intervention, but are incompletely defined. The viral glycoprotein (GP) mediates filovirus entry into host cells. Recent studies revealed important insights into the host cell molecules engaged by GP for cellular entry. The binding of GP to cellular lectins was found to concentrate virions onto susceptible cells and might contribute to the early and sustained infection of macrophages and dendritic cells, important viral targets. Tyrosine kinase receptors were shown to promote macropinocytic uptake of filoviruses into a subset of susceptible cells without binding to GP, while interactions between GP and human T cell Ig mucin 1 (TIM-1) might contribute to filovirus infection of mucosal epithelial cells. Moreover, GP engagement of the cholesterol transporter Niemann-Pick C1 was demonstrated to be essential for GP-mediated fusion of the viral envelope with a host cell membrane. Finally, mutagenic and structural analyses defined GP domains which interact with these host cell factors. Here, we will review the recent progress in elucidating the molecular interactions underlying filovirus entry and discuss their implications for our understanding of the viral cell tropism
Paula : [Portraits of Paula Beer-Hofmann].
No full textThe name "Paula" is written in gold on the hard cover of this album. The photographs depict Paula Beer-Hofmann as a teenager and in her twenties, dressed in various outfits, sometimes with her hair up, other times with her hair down, sometimes in hats, sometimes with her daughter Miriam. Profile portraits and forward-facing portraits are included. Inscriptions on the photographs note Paula's age and the location, where the photograph was taken, most commonly in Vienna. Some photographs were taken in Atelier d’Ora in Vienna, others by Perscheid in Berlin.The following photographs are included in this album: F 10015, F 10016, F 10017, F 10018, F 10019, F 10020, F 10021, F 10022, F 10023, F 10024, F 10024A, F 10025, F 10026, F 10027, F 10028, F 10029, F 10030, F 10031, F 10032, F 10033, F 10034, F 10035, F 10036, F 10037, F 10038, F 10039, F 10040, F 10041, F 10042Paula (Pauline) Lissy was born in Vienna, Austria in 1879. In 1897 she married the author Richard Beer-Hofmann; their daughter Miriam Beer-Hofmann Lens was born in the same year.Digital Imag
Death of Murad Hofmann: Some thoughts and recollections
No full textBorn a Catholic in Germany’s Aschaffenburg, Hofmann began his university education at Union College in New York in 1951. Then he studied law at Munich and Harvard Universities with a PhD in jurisprudence from the former in 1957 and a Master of Law from Harvard Law School in 1960. A prolific author of about a dozen books and an eloquent speaker, Hofmann embraced Islam in 1980, performed hajj in 1992 and describes his hajj experiences and his thoughts and reflections on various aspects of Islam in Journey to Makkah
Selection sequences in MANET
No full textSelection sequences in MANET / H. Hofmann ; M. Theus. - In: Computational statistics. 13. 1998. S. 77-8
Evidence that Processing of the Severe Fever with Thrombocytopenia Syndrome Virus Gn/Gc Polyprotein Is Critical for Viral Infectivity and Requires an Internal Gc Signal Peptide.
No full textThe severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging, highly pathogenic bunyavirus against which neither antivirals nor vaccines are available. The SFTSV glycoproteins, Gn and Gc, facilitate viral entry into host cells. Gn and Gc are generated from a precursor protein, Gn/Gc, but it is currently unknown how the precursor is converted into the single proteins and whether this process is required for viral infectivity. Employing a rhabdoviral pseudotyping system, we demonstrate that a predicted signal sequence at the N-terminus of Gc is required for Gn/Gc processing and viral infectivity while potential proprotein convertase cleavage sites in Gc are dispensable. Moreover, we show that expression of Gn or Gc alone is not sufficient for host cell entry while particles bearing both proteins are infectious, and we provide evidence that Gn facilitates Golgi transport and virion incorporation of Gc. Collectively, these results suggest that signal peptidase liberates mature Gc from the Gn/Gc precursor and that this process is essential for viral infectivity and thus constitutes a potential target for antiviral intervention
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