1,721,122 research outputs found
LAN881481 Supplemetal Material - Supplemental material for A safe bet? Inter-laboratory variability in behaviour-based severity assessment
No full textSupplemental material, LAN881481 Supplemetal Material for A safe bet? Inter-laboratory variability in behaviour-based severity assessment by Paulin Jirkof, Ahmed Abdelrahman, André Bleich, Mattea Durst, Lydia Keubler, Heidrun Potschka, Birgitta Struve, Steven R Talbot, Brigitte Vollmar, Dietmar Zechner and Christine Häger in Laboratory Animals</p
LAN881664 Supplemetal Material - Supplemental material for Semi-automated generation of pictures for the Mouse Grimace Scale: A multi-laboratory analysis (Part 2)
No full textSupplemental material, LAN881664 Supplemetal Material for Semi-automated generation of pictures for the Mouse Grimace Scale: A multi-laboratory analysis (Part 2) by Lisa Ernst, Marcin Kopaczka, Mareike Schulz, Steven R Talbot, Birgitta Struve, Christine Häger, André Bleich, Mattea Durst, Paulin Jirkof, Margarete Arras, Roelof Maarten van Dijk, Nina Miljanovic, Heidrun Potschka, Dorit Merhof and Rene H Tolba in Laboratory Animals</p
Supplemental material for Nest-building performance in rats: impact of vendor, experience, and sex
No full textSupplemental Material for Nest-building performance in rats: impact of vendor, experience, and sex by Kerstin Schwabe, Lena Boldt, André Bleich, Roelof Maarten van Dijk, Simeon Oscar Arnulfo Helgers, Christine Häger, Marta Nowakowska, Ann-Kristin Riedesel, Katharina Schönhoff, Birgitta Struve, Jürgen Wittek and Heidrun Potschka in Laboratory Animals</p
LAN883319 Supplemetal Material2 - Supplemental material for Defining body-weight reduction as a humane endpoint: a critical appraisal
No full textSupplemental material, LAN883319 Supplemetal Material2 for Defining body-weight reduction as a humane endpoint: a critical appraisal by Steven R Talbot, Svenja Biernot, Andre Bleich, Roelof Maarten van Dijk, Lisa Ernst, Christine Häger, Simeon Oscar Arnulfo Helgers, Babette Koegel, Ines Koska, Angela Kuhla, Nina Miljanovic, Franz-Tassilo Müller-Graff, Kerstin Schwabe, Rene Tolba, Brigitte Vollmar, Nora Weegh, Tjark Wölk, Fabio Wolf, Andreas Wree, Leonie Zieglowski, Heidrun Potschka and Dietmar Zechner in Laboratory Animals</p
LAN883319 Supplemetal Material1 - Supplemental material for Defining body-weight reduction as a humane endpoint: a critical appraisal
No full textSupplemental material, LAN883319 Supplemetal Material1 for Defining body-weight reduction as a humane endpoint: a critical appraisal by Steven R Talbot, Svenja Biernot, Andre Bleich, Roelof Maarten van Dijk, Lisa Ernst, Christine Häger, Simeon Oscar Arnulfo Helgers, Babette Koegel, Ines Koska, Angela Kuhla, Nina Miljanovic, Franz-Tassilo Müller-Graff, Kerstin Schwabe, Rene Tolba, Brigitte Vollmar, Nora Weegh, Tjark Wölk, Fabio Wolf, Andreas Wree, Leonie Zieglowski, Heidrun Potschka and Dietmar Zechner in Laboratory Animals</p
Modulating P-glycoprotein Regulation as a Therapeutic Strategy for Pharmacoresistant Epilepsy
No full text
Transporter hypothesis of drug-resistant epilepsy: challenges for pharmacogenetic approaches
No full text Drug resistance in epilepsy is considered a complex and multifactorial problem. Overexpression of efflux transporters at the blood–brain barrier is discussed as one factor that might limit brain penetration and efficacy of antiepileptic drugs. Whereas experimental data render support for this hypothesis, there is still a lack of sufficient clinical evidence indicating a functional role of efflux transporters. Pharmacogenetic analysis has been considered as one approach in the evaluation of a putative link between transporters and drug-resistant epilepsy. However, the likelihood of a multifactorial nature of drug resistance and the complexity of the events regulating transporters pose a major challenge to any attempt at linking selected genetic polymorphisms to the outcome of drug therapy. In this article, the evidence for an impact of efflux transporters on the response to antiepileptic drugs is discussed, focusing in particular on the different issues presenting a challenge for pharmacogenetic approaches in this field. </jats:p
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