320 research outputs found
Zack Spratt\u27s Butcher\u27s Cookbook - Accession 678 - M301 (352)
No full textThe Butcher’s Cookbook consists of a leather bound notebook containing instructions on preserving and curing meat, and recipes for various meat dishes from around the 1910s. The name A.D. Payne is on the front cover and is the author of the book. Zack Spratt collected cookbooks, many of which are housed in the Winthrop Library, and speculated that “these notes were taken by someone [A. D. Payne] working in a packing plant.” Zack Spratt is most likely Zaccheus Spratt (1884-1978) and was a relative of the Fort Mill, SC Spratt Family.https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/1652/thumbnail.jp
sj-docx-1-cre-10.1177_02692155221087424 - Supplemental material for Stroke survivors’ perceptions of the factors that influence engagement in activity outside dedicated therapy sessions in a rehabilitation unit: A qualitative study
No full textSupplemental material, sj-docx-1-cre-10.1177_02692155221087424 for Stroke survivors’ perceptions of the factors that influence engagement in activity outside dedicated therapy sessions in a rehabilitation unit: A qualitative study by Heidi Janssen, Marie-Louise Bird, Julie Luker, Annie McCluskey, Jannette Blennerhassett, Louise Ada, Julie Bernhardt and Neil J Spratt in Clinical Rehabilitation</p
ngungara_backed_artefacts: v1.0.0
No full text<p>The data and R code to accompany Way, A. M., Koungoulos, L., Wyatt-Spratt, S., & Hiscock, P. (2023). Investigating hafting and composite tool repair as factors creating variability in backed artefacts: Evidence from from Ngungara (Weereewa/Lake George), Southeastern Australia. <em>Archaeology in Oceania</em>, 1–18.</p>
<p>Code Author: Amy Mosig Way, Loukas Koungoulos, Simon Wyatt-Spratt</p>
<p>Abstract: Across the Australian continent, backed artefacts are produced in enormous numbers during the mid-late Holocene. Previous examinations have revealed variation in the average shape of these artefacts, at both continental and regional scales. To better understand the factors creating this variability, we examine a large assemblage of backed artefacts from Ngungara (Weereewa/Lake George), in southeastern Australia. This is one of the few open sites in Australia which has high-resolution evidence for spatially distinct, short-term workshops. Within these well-bounded workshops both locally manufactured and imported backed artefacts are present. However, across this landscape the shape of these artefacts is not uniform; rather similarly shaped backed artefacts are concentrated in different workshop areas. Through the analysis of backed artefacts in different workshops, we suggest that ‘insert copying’ or the replacement of spent inserts with similarly shaped, locally manufactured artefacts creates variability in backed artefact shape.</p>
<p>Acknowledgements: The authors would like to thank the traditional landowners for their assistance in undertaking the original PhD study and for sharing language names for the lake.</p>
sj-docx-1-wso-10.1177_17474930231201360 – Supplemental material for Secondary prevention of stroke. A telehealth-delivered physical activity and diet pilot randomized trial (ENAbLE-pilot)
No full textSupplemental material, sj-docx-1-wso-10.1177_17474930231201360 for Secondary prevention of stroke. A telehealth-delivered physical activity and diet pilot randomized trial (ENAbLE-pilot) by Coralie English, Emily R Ramage, John Attia, Julie Bernhardt, Billie Bonevski, Meredith Burke, Margaret Galloway, Graeme J Hankey, Heidi Janssen, Richard Lindley, Elizabeth Lynch, Chris Oldmeadow, Catherine M Said, Neil J Spratt, Karly Zacharia, Lesley MacDonald-Wicks and Amanda Patterson in International Journal of Stroke</p
Coastal Erosion at Spratt Bight Beach, San Andrés: A study on its cause and the applicability of the Building with Nature approach
No full textSan Andrés is a Colombian-Caribbean Island located 800 km from the Colombian coast. On its Eastern side there is a barrier reef formation protecting the island from offshore incident waves. Due to the protected environment created by the coral reef, sandy beaches can be formed on the East side of the island. During normal conditions, waves come predominantly form the East (90% of the wave climate), have significant wave height of 2 m and period of 8 s. Besides, San Andrés is situated on the Caribbean hurricane route, which can cause an enormous damage to the island. The storm season at San Andrés is between October and December, which is also when major erosion events take place.The economy of San Andrés is mostly built upon tourism, specially related to its biodiverse ecosystems and Caribbean beaches. The island’s ecological environment is composed by mangroves, seagrasses, and coral reefs, attracting a wide spectrum of fauna and flora to its ecosystems.During the Masterplan for Coastal Erosion (PMEC), San Andrés was pointed out as a location in which coastal erosion is problematic. In a follow-up of this Masterplan, the island was elected to be part of a program in which solutions against coastal erosion would be presented. This research is part of this project, as a parallel trajectory to get a more profound understanding of the system and the possible mitigation measures that could be applied on the island.With increasing urbanization and frequency of extreme weather events, erosion is becoming a problem with which San Andrés and its residents are repeatedly having to deal. Erosion is specially problematic for the Northern part of the island, called Spratt Bight. This region is not only the most densely populated area of the island, but also economically and touristically very important. Its beach presents periodically eroding patterns during storm seasons, when wave action drives the sediment towards the East, decreasing its beach width almost to none. A decreasing beach width has a direct negative impact on tourism, making coastal erosion in Spratt Bight not only a coastal safety problem, but also an economic issue.This study aims to look into the main hydro- and morphological processes driving coastal erosion in Spratt Bight and, using the Building with Nature philosophy, propose a set of solutions to mitigate this problem. To reach this objective data analysis and literature research has been carried out, after which different environmental conditions were modelled using the numerical model Delft3D. During these activities it was found that independently of its direction, waves approaching San Andrés break upon the coral reef and induce a water level set up inside the coral lagoon. The difference in water level in- and outside the lagoon generates a current and sediment transport, which is directed towards the western opening in the coral reef.When the Northern waves approach the island (1.5% of the wave climate), the same water level set-up phenomenon is observed. However, as waves are approaching form the North, they not only break upon the reef, but are also able to enter the sheltered lagoon through the western opening in the coral reef. These waves are able to bend around the reef reaching the shore and the headland on the Northern part of the island, inducing a longshore current and a sediment transport that is southeastward directed. The result is that Northern waves are mostly responsible for a strong westward and erosive sediment transport pattern. These waves are mostly observed between October and March, which coincides with the storm season in San Andrés. Besides, it was found that the Eastern waves are responsible for restoring the (dynamic) equilibrium profile of Spratt Bight Beach. However, this restoring force has a less strong intensity, taking more time to restore the beach than to disrupt its equilibrium.The solutions proposed include seagrass restoration to enhance ecology, restrain sediment transport and attenuate wave heights; the beneficial reuse of dredged material, to nourish Spratt Bight Beach; and finally, the implementation of artificial coral reefs as breakwaters to prevent the newly nourished sediment to be lost from the system. Besides, artificial coral reefs enhance the ecosystem by attracting fauna and flora increasing biodiversity. All proposed solutions have a positive impact on the beaches and therefore on tourism and the economy of the island. This makes them multifunctional solutions, serving the main goal of protecting the beach while at the same time creating benefits for other functions and values in the area. Following in this way the prescriptions of the Building with Nature design approach by van Eekelen and Bouw (2020).Civil Engineerin
Evaluating Seeding Galveston: Assessing Food Security and Health-Related Outcomes
No full textProgram evaluation is a crucial step in the success of community-based programs, as it allows stakeholders and community organizations to determine the success of our efforts and make changes where necessary to improve our community programs. Evaluations are fluid and cannot just be done once, thus the importance of establishing an evaluation program within community organizations. Seeding Galveston, a relatively young non-profit organization on Galveston Island, seeks to increase food security for low-income residents and provide a sustainable food source for all. Seeding Galveston requires an evaluation to determine how to further the growth of their organization and if they are using their resources in the best way possible. The goal of this proposal is to develop and begin implementation of an evaluation plan such that Seeding Galveston can evaluate current programs and make self-evaluation a requirement for all new programs, thus leading to a sustainable evaluation technique for the life of their organization
Abstract 902: Cancer-stem-cell (CSC) marker, DCLK1-S, enhances invasive potential of cancer cells by phosphorylating/activating NFATc2: role of COL3A1 and SPARC in mediating metastatic effects of DCLK1-S/NFATc2
No full textAbstract
DCLK1 expression is critically required for colon carcinogenesis in mice, and for maintaining tumorogenic potential of human colon cancer cells (hCCCs) (Singh et al, 2016). Down-regulation of DCLK1, combined with chemoprevention, eliminates CSCs, and avoids colon cancer relapse (Kantara et al, 2014). We recently discovered that long (L) and Short (S) isoforms of DCLK1 (DCLK1-L/DCLK1-S) are transcribed by two separate promoters (5’(α)/IntronV(β)) in the hDCLK1-gene (O’Connell et al, 2015). During adenoma-carcinoma sequence of colon-tumorigeneses, L-isoform becomes silenced by DNA-methylation while S-isoform gets upregulated by many fold (O’Connell et al, 2015). S-isoform specifically imparts invasive potential to cancer cells, unlike L-isoform (Singh et al, 2016); others have similarly reported metastatic potential of DCLK1 expressing cancer cells (Ito et al, 2016). Thus the goal of our studies was to evaluate molecular/genetic pathways mediating invasive effects of DCLK1-S in cancer cells. Isogenic clones of HCT116-cells, wild-type or down-regulated for DCLK1-S (HCT-C/HCT-D), were subjected to next generation sequencing and pathways analysis. SPARC and COL3A1 emerged as two candidate genes/proteins, which were decreased/increased by several fold in response to loss/overexpression of DCLK1-S, respectively. We present data confirming a critical role of COL3A1 and SPARC in mediating metastatic effects of DCLK1-S expression in hCCCs. We additionally discovered that DCLK1-S functions as a specific kinase for the transcriptional factor, NFATc2, and phosphorylates 53SPPS56 motif of NFATc2, resulting in activation of NFATc2 and increased expression of COL3A1. Conclusions. Our novel findings, suggest for the first time, that DCLK1-S expression by colonic tumors in humans, mediates invasive potential of colon cancer cells by phosphorylation/activation of NFATc2, resulting in up-regulation of COL3A1/SPARC; the latter proteins re-model extracellular matrix, assisting unhindered invasion of colon cancer cells.
Note: This abstract was not presented at the meeting.
Citation Format: Malaney O. Connell, Shubhashish Sarkar, Heidi Spratt, Steven Widen, Thomas G. Wood, Pomila Singh. Cancer-stem-cell (CSC) marker, DCLK1-S, enhances invasive potential of cancer cells by phosphorylating/activating NFATc2: role of COL3A1 and SPARC in mediating metastatic effects of DCLK1-S/NFATc2 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 902. doi:10.1158/1538-7445.AM2017-902</jats:p
A comparison of three methods used to determine functionally important protein residues
No full textA new method for determining functionally important protein residues is analyzed and compared with two previously existing methods. This thesis presents the analysis of several different protein sequences and shows how the functionally important protein residues compare between the evolutionary trace method, the maximum likelihood method of protein evolution, and the Hidden Markov method of protein evolution. The results are presented graphically as well as structurally since structure information is known about all the protein sequences studied. All three methods produce similar results for most of the proteins and show that the most highly conserved protein residues are detectable by all three methods but that the less conserved important residues may not always be identified by all methods
Cellular-responses of migratory grasshoppers (melanoplus-sanguinipes F) and African desert locusts (schistocerca-gregaria L) to diplotriaena-tricuspis (nematoda, diplotriaenoidea)
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