5,007 research outputs found
Additional data: Meta_Analysis of Urinary Uromodulin
No full textAdditional Data pertaining to publication: Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin
Uromodulin, the most abundant protein excreted in normal urine, plays major roles in kidney physiology and disease. The mechanisms regulating the urinary excretion of uromodulin remain essentially unknown. We conducted a meta-analysis of genome-wide association studies for raw (uUMOD) and indexed to creatinine (uUCR) urinary levels of uromodulin in 29,512 individuals of European ancestry from 13 cohorts. We tested whether variants in disease-causing genes associate with uromodulin levels and investigated the effects of keratin-40 (KRT40) on uromodulin processing. Results: Two genome-wide significant signals were identified for uUMOD: A novel locus (P 1.24E-08) over the KRT40 gene coding for KRT40, a type1 keratin expressed in the kidney, and the UMOD-PDILT locus (P 2.17E-88), which included two independent sets of SNPs spread over UMOD and PDILT. The meta-GWAS for uUCR yielded two genome-wide significant signals on the UMOD-PDILT locus and at the novel WDR72 locus previously associated with kidney function, urine pH and risk of kidney stones.Additional Data pertaining to publication: Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin
If you use this dataset, please cite the manuscript: "Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin". Joseph CB et al. Submitted to JASN.
This dataset consists of additional summary statisics of the meta-analysis of genome-wide association studies (GWAS) of urinary Uromodulin (uUMOD) and urinary Uromodulin/Creatinine ratio from subsets of the cohorts analysed in the original dataset
"MarkerName" "Allele1" "Allele2" "Freq1" "FreqSE"
[6] "MinFreq" "MaxFreq" "Effect" "StdErr" "P"
[11] "Direction" "HetISq" "HetChiSq" "HetDf" "HetPVal"
[16] "CHR" "BP" "ID"
Meta-analysis summary stat column descriptions
MarkerName - Position of the SNP in chromosome:position format
Allele1 - allele for which results are reported
Allele2 - other allele
Freq1 - Allele1 average frequency
FreqSE - Standard error of Freq1
MinFreq - Minimum frequency Allele1
MaxFreq - Maximum frequency Allele1
Effect - association effect size
StdErr - standard error of the effect size
P - association p-value
Direction - Direction of association for each cohort
HetISq - Hardy-Weinberg deviation across cohorts
HetChiSq - Hardy-Weinberg ChiSq
HetDf - Hardy-Weinberg degrees of freedom
HetPVal - Hardy-Weinberg equillibrium p-value
CHR- chromosome of SNP (b37)
BP- position of SNP (b37)
ID - rsID of the SNP, where availabl
Meta_Analysis of Urinary Uromodulin
No full textUromodulin, the most abundant protein excreted in normal urine, plays major roles in kidney physiology and disease. The mechanisms regulating the urinary excretion of uromodulin remain essentially unknown. We conducted a meta-analysis of genome-wide association studies for raw (uUMOD) and indexed to creatinine (uUCR) urinary levels of uromodulin in 29,512 individuals of European ancestry from 13 cohorts. We tested whether variants in disease-causing genes associate with uromodulin levels and investigated the effects of keratin-40 (KRT40) on uromodulin processing. Results: Two genome-wide significant signals were identified for uUMOD: A novel locus (P 1.24E-08) over the KRT40 gene coding for KRT40, a type1 keratin expressed in the kidney, and the UMOD-PDILT locus (P 2.17E-88), which included two independent sets of SNPs spread over UMOD and PDILT. The meta-GWAS for uUCR yielded two genome-wide significant signals on the UMOD-PDILT locus and at the novel WDR72 locus previously associated with kidney function, urine pH and risk of kidney stones.Please see "Uromodulin Meta_Analysis_ReadMe file.txt". Please note the '.txt' files in this dataset contain millions of rows of tab-delimited data
Caroline Gordon Collection
No full textArrangement Description
EXTENT
Linear Feet: 2 linear feet
Number of Containers: 2 boxes
Series 1: Writings, 31 files
Series 2: Lectures, 19 files
Series 3: Courses, 10 files
Series 4: Book Reviews, 5 files
Series 5: About Caroline Gordon,8 files
Series 6: Correspondence, 18 files
Series 7: Books, 5 books
Series 8: Media: 9 digital files, 9 cassettes, 2 reelsCOLLECTION DETAILS
<---Please open FindingAid .pdf under "FILES" to see full collection details To request any materials from this collection please email: [email protected]
BIOGRAPHICAL / Historical Note: Twentieth-century novelist Caroline Gordon was born into the Kentucky line of the extensive Meriwether family in 1895. Exploration of the family's past and its evolution is a major theme of her fiction. She grew up at Merry Mont in Todd County, near Clarksville where she received her early education. She earned a Bachelor of Arts degree from Bethany College in 1916. Her father is the idealized subject of Gordon's second novel, Alec Maury, Sportsman (1934), and the central character in her much-anthologized story, "Old Red." Gordon taught briefly; then, as a journalist, she became one of the first reviewers to comment favorably on a new Nashville-based magazine of poetry, The Fugitive. During the summer of 1924, Robert Penn Warren, a Todd County neighbor, introduced her to Allen Tate. Within a year they were married and living in New York City, where their daughter, Nancy Meriwether was born. With Tate, she began a period of life abroad, devoted to writing and sustained by various fellowships granted to one or the other. In London, Gordon was secretary to the influential British writer Ford Madox. In 1930 the Tates returned to the United States and settled in Clarksville in a house provided by Tate's brother Ben and called "Benfolly." Both Tates were exceptionally hospitable to friends and encouraging to younger writers. Both were prolific correspondents, generous with constructive criticism. (Gordon eventually became mentor to several writers, most notably Flannery O'Connor). Although she had to wrest time for her writing from domestic and social obligations, the eight Benfolly years were especially productive for Gordon, who published four novels and several stories before 1937. The first novel was Penhally (1931), followed by Alec Maury, Sportsman (1934), None Shall Look Back (1937), and The Garden of Adonis (1937), studies of the southern family during the Civil War and Great Depression. Academic appointments of the 1940s took the Tates throughout the Southeast and to Princeton, where they established a home near their daughter, who married psychiatrist Percy Wood in 1944. During this time Gordon published her fifth novel, Green Centuries (1941). Her second related group of novels, The Woman on the Porch (1944), which deals with a troubled marriage, The Strange Children (1951), based on life at Benfolly, and The Malefactors (1956), is informed by her conversion to Roman Catholicism. She and her husband wrote The House of Fiction (1950), which was followed by Gordon's How to Read a Novel in 1957. Gordon lived in Princeton until 1973, teaching, and writing: The Glory of Hera (1972). An appointment in the creative writing program drew her to the University of Dallas (Gordon was 77 years old when she proposed the new creative writing program at UD). When her health began to fail in 1978, she moved to San Cristobal de las Casas in Chapas, Mexico, with her daughter and family. She died there on April 11, 1981.
COLLECTION DESCRIPTION Caroline Gordon (1895-1981) was an American author. This collection consists of manuscripts of Gordon's work, including novels, lectures, and poetry during her time at the University of Dallas. It also includes correspondence with authors and family members, writings of others, and photographs.
Lectures and Commentary available here: https://hdl.handle.net/20.500.14026/2548University of Dalla
Fostering Hope Through Palliative Rehabilitation
No full textCancer patients’ need for rehabilitation is growing, as more and more people live with the long-term consequences of disease and its treatment due to early detection and improved treatment regimens. There are a number of people living with incurable cancer who have symptoms that need to be managed for many years, paralleling long-term conditions. Beyond clinical management, a sense of hope is vital in enhancing their quality of life
The role english plays in the construction of professional identities in nest-nnes bilingual marriages in İstanbul
No full textCaroline Fell Kurban (MEF Author)…WOS:000389065100011Book Citation Index- Social Sciences and HumanitiesArticle; Book ChapterOcakYÖK - 2014-1
Croatian Cohorts Data Dictionary
Full text linkThis Croatian biobank is family-based, cross-sectional genetics studies of population cohorts from the Island of Korcula (3000 individuals) and the mainland city of Split (1000 individuals). Blood samples were collected along with many clinical and biochemical measures and lifestyle and health questionnaires.
The CROATIA-Korcula and CROATIA-Split studies were funded by grants from the Medical Research Council (UK), from the Republic of Croatia Ministry of Science, Education and Sports (108-1080315-0302; 216-1080315-0302) and the Croatian Science Foundation (8875); and the CROATIA-Korčula genotyping was funded by the European Union framework program 6 project EUROSPAN (LSHGCT2006018947).
This data dictionary outlines what phenotypes were measured and what questions volunteers were asked and indicates the data that is available.
Croatian biobank website:https://mefst.unist.hr/research/research-groups-and-laboratories/10-001-dalmatian-croatian-biobank/5038See Croatia_Cohorts_Data_Dictionary_ReadMe.tx
The Song of Songs in late Elizabethan, Jacobean and Caroline poetry
Full text linkThis thesis is about reading. Working on the understanding that all texts read other texts, it aims to uncover something of how English poets from 1590-1650 read the Song of Songs, by analyzing when and how they use it in their poetry. By looking at poetic readings, rather than theological ones, it also explores the connections and distinctions between reading literature and reading Scripture. As both Scripture and lyric love poetry, the Song of Songs has participated in theological and literary discourse over a long period. The Introduction gives background on both kinds of reading, and how they have been applied to the Song of Songs. It also sets out the structure of the thesis. Chapter 2 surveys theological writing about the Song of Songs produced during the period. The material includes sermons, commentaries, household advice books, hymns and translations, including poetic translations. There is a stable core of interpretation, which reads the Song as primarily about the relationship between Christ and the Church, or the individual soul, or both. Within this stable core, however, there is a wide variety of interpretations. Chapters 3-5 are themed, and look at how poets handle the three topics of the feminine voice, beauty and desire when they read the Song of Songs. The first poet considered in each chapter is Aemilia Lanyer, who provides a plumb-line for the exposition. As a poet seeking elite patronage, Lanyer is typical of her age in many important respects; but she also challenges expectations about poets of the period. The other poets considered are Shakespeare, Southwell, Mary Sidney, Countess of Pembroke, Spenser, Donne and Crashaw. The Conclusion considers what light these poetic readings shed on the relationship between Scripture and literature
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