3,096 research outputs found
Providence College Faculty Author Series 2012-2013: Dr. Adrian Weimer
Get PDFDr. Adrian Weimer (History, Providence College) discusses her new book Martyrs\u27 Mirror: Persecution and Holiness in Early New England and the cultural importance of martyrdom within Colonial America
Providence College Faculty Author Series 2012-2013: Dr. Adrian Weimer
No full textDr. Adrian Weimer (History, Providence College) discusses her new book Martyrs\u27 Mirror: Persecution and Holiness in Early New England and the cultural importance of martyrdom within Colonial America
Adrian Matejka, 34th Annual ODU Literary Festival
No full textAdrian Matejka is the author of The Devil’s Garden and Mixology, which was a winner of the 2008 National Poetry Series. He is the recipient of two Illinois Arts Council Literary Awards and fellowships from Cave Canem and the Lannan Foundation. His work has been featured in American Poetry Review, The Best American Poetry 2010, and Ploughshares, among other journals and anthologies. He teaches at Southern Illinois University Edwardsville
Response to comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'
Get PDFIn 2016, we reported four substantial observations of APECED/APS1 patients, who are deficient in AIRE, a major regulator of central T cell tolerance (Meyer et al., 2016). Two of those observations have been challenged. Specifically, 'private' autoantibody reactivities shared by only a few patients but collectively targeting >1000 autoantigens have been attributed to false positives (Landegren, 2019). While acknowledging this risk, our study-design included follow-up validation, permitting us to adopt statistical approaches to also limit false negatives. Importantly, many such private specificities have now been validated by multiple, independent means including the autoantibodies ' molecular cloning and expression. Second, a significant correlation of antibody-mediated IFN a neutralization with an absence of disease in patients highly disposed to Type I diabetes has been challenged because of a claimed failure to replicate our findings (Landegren, 2019). However, flaws in design and implementation invalidate this challenge. Thus, our results present robust, insightful, independently validated depictions of APECED/APS1, that have spawned productive follow-up studies.Non peer reviewe
To Ki or Not to Ki: Re-Evaluating the Use and Potentials of Ki-67 for T Cell Analysis
Get PDFThis study discusses substantive advances in T cell proliferation analysis, with the aim to provoke a re-evaluation of the generally-held view that Ki-67 is a reliable proliferation marker per se, and to offer a more sensitive and effective method for T cell cycle analysis, with informative examples in mouse and human settings. We summarize recent experimental work from our labs showing that, by Ki-67/DNA dual staining and refined flow cytometric methods, we were able to identify T cells in the S-G2/M phases of the cell-cycle in the peripheral blood (collectively termed “T Double S” for T cells in S-phase in Sanguine: in short “TDS” cells). Without our refinement, such cells may be excluded from conventional lymphocyte analyses. Specifically, we analyzed clonal expansion of antigen-specific CD8 T cells in vaccinated mice, and demonstrated the potential of TDS cells to reflect immune dynamics in human blood samples from healthy donors, and patients with type 1 diabetes, infectious mononucleosis, and COVID-19. The Ki-67/DNA dual staining, or TDS assay, provides a reliable approach by which human peripheral blood can be used to reflect the dynamics of human lymphocytes, rather than providing mere steady-state phenotypic snapshots. The method does not require highly sophisticated “-omics” capabilities, so it should be widely-applicable to health care in diverse settings. Furthermore, our results argue that the TDS assay can provide a window on immune dynamics in extra-lymphoid tissues, a long-sought potential of peripheral blood monitoring, for example in relation to organ-specific autoimmune diseases and infections, and cancer immunotherapy
Performing the archive: following in the footsteps
Get PDFUsing documentation of Mike Pearson's performance 'Bubbling Tom', Deirdre Heddon attempts to step into his shoes and re-perform it
Autoimmunity: Is antigen-specific suppression now unsuppressed?
No full textAbstractRecent studies suggest that putative regulatory lymphocytes can effect antigen-specific down-regulation of autoimmunity. But we have yet to see how much this improves our picture of autoimmune disease progression
Using art and history to communicate immunology to a broad audience.
No full textFrancesca Di Rosa works on T cells and is committed to science outreach. Together with Adrian Hayday, she recently conceptualized and delivered the exhibit ‘Vaccination, a time machine’ at the Royal Society Summer Exhibition in London. Here, she shares her thoughts on how to communicate a core scientific content with artistic and historical input, according to her ‘5C’ formula
Electrochemical-control of abrasive polishing and machining rates, U.S. Patent 6,171,467
No full textAn apparatus and method is disclosed; both of which use electrochemistry to selectively grow and remove hard oxide coatings on metals, and capacitive double layers on non-metals and semiconductors in order to predict and control the rate of surface abrasion during planarization of the surface of such materials
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