41 research outputs found
Effect of annealing temperature on physical properties of solution processed nickel oxide thin films
No full textBiodegradable Polymer Use in Drug Delivery Systems: A Comprehensive Review
No full textBiodegradable polymers have revolutionized the field of drug delivery systems, offering a promising solution to the limitations of traditional drug administration techniques. These polymers can be designed to degrade at specific rates, releasing therapeutics in a controlled and sustained manner, thereby improving bioavailability and reducing side effects. This review provides an overview of biodegradable polymers, including natural polymers like collagen, albumin, and gelatin, as well as synthetic polymers like polyesters, polyorthoesters, and polyphosphoesters. Here discuss the types of biodegradable polymers, their mechanisms, and benefits in drug delivery systems, including controlled release, targeted release, transdermal delivery, gene delivery, and tissue engineering. The review also highlights the future prospects and trends in biodegradable polymers, including the development of new polymers, blends, and nanoparticles.
Keywords: Biodegradable polymers, Drug delivery systems, Controlled release, Targeted delivery, Regenerative medicin
Artificial Intelligence in Pharmaceutical Research
No full textArtificial intelligence (AI) is transforming the pharmaceutical industry by accelerating medication development and discovery. AI technologies, including machine learning and deep learning, are being applied in various areas, such as drug design, target discovery, preclinical research, and personalized medicine. AI can analyze vast amounts of data, identify patterns, and make predictions, thereby improving the efficiency and effectiveness of the drug development process. This review highlights the applications of AI in pharmaceutical research, including drug discovery, target identification, and preclinical research. We also discuss the challenges associated with AI in pharmaceutical research, such as data quality and integration, regulatory frameworks, and the need for skilled professionals. Also, the future directions of AI in pharmaceuticals, including the potential for AI to revolutionize personalized medicine and improve patient outcomes. Overall, AI has the potential to revolutionize the pharmaceutical industry by streamlining the drug development process, improving patient outcomes, and reducing costs.
Keywords: Artificial Intelligence, Machine Learning, Drug Discovery, Personalized Medicine, Target Discovery
A Holistic Review of Thrombosis Covering Diagnosis, Conventional Treatment, Nutraceutical Prevention and Advanced Drug Delivery
No full textThrombosis, or the formation of blood clots within blood vessels, is a serious medical condition that can lead to life-threatening complications. It is a complex process involving interactions between hemostatic, hemodynamic, and surface parameters. The risk factors for thrombosis include cancer, surgery, trauma, and genetic conditions. According to research, cancer patients are at a higher risk of developing thrombosis, with venous thromboembolism being the second most common cause of death in these patients. Understanding the causes, diagnosis, and treatment options for thrombosis is crucial for preventing and managing this condition. This review aims to provide an overview of the current knowledge on thrombosis, including its pathophysiology, risk factors, diagnostic tools, and treatment.
Keywords: Thrombosis, Blood clots, Hemostasis, Thrombolytic therapy, Anticoagulation, Cardiovascular diseas
Design of Balancing Converter for Bipolar DC Grids Using Series Connected MOSFET Switches
No full textGlobal electricity usage has been increasing exponentially over the last 40 years and with the current pace of population and economic growth, the same trend will continue in the coming years. However, the current electricity generation is predominantly fossil fuels based, which makes the overall process unsustainable and polluting, and is contributing directly to the menace of global warming. The need of the hour is to transition to renewable and sustainable sources of electricity generation such as solar, wind etc.However, the major bottleneck in the large-scale implementation of RESs is the intermittent availability and their integration into existing AC grids as the RESs are predominantly DC sources. In order to tackle the issue of intermittency various energy storage solutions are being developed. Further, as a solution to the issue of integrating RESs into the current electricity distribution system, DC distribution grids are being developed. The DC distribution architecture is of two types, Unipolar and Bipolar distribution systems characterized by the number of wires used for power transmission; 2 wires for unipolar and 3 wires for Bipolar. Out of the two, Bipolar systems have inherent advantages of flexibility, stability and efficiency over unipolar systems. Current thesis focuses on series connected switch configuration of voltage balancing converter for bipolar DC power distribution systems. For this thesis, various topologies of voltage balancers for bipolar dc distribution systems were studied and a buck boost-based series switch-connected voltage balancer topology was chosen for the final design. For this topology, using MATLAB the parameterization and optimization of magnetic components of the converter were performed. The optimized configuration was then modeled and simulated using LTSpice.Post this, a comparison between different methods adopted to account for the unbalanced voltage sharing across the series-connected switch configuration of the balancing converter owing to the non-linearities present in the circuit was done. Based on this study, the most prominent of the methods is then integrated to the LTSpice model.Electrical Engineerin
A study on photoelectrochemical properties of ZnO@ZnS nanostructures synthesized via facile ion-exchange approach
No full textConfluence of Nativity, Relativity and Duality of Transgenderism in and through Laxmi’s* Red Lipstick: The Men in My Life
No full textIn order to witness the convergence of ‘mainstream’ with the ‘sidelined’ there has to be a change in the mindset of the people. As in the past, human beings could develop an unbiased attitude and openness in accepting and recognising the transgenders. The article too aims to accomplish this sort of convergence - meeting of the dominating male and female genders with the sidelined transgenders not periodically, but on a day to day exchange, to observe and attain a liberal community.
The locality of study that the article fixes is India and the transgender community of India is the broad area taken for study and the text taken for study is Red Lipstick: The Men in My Life, authored by Laxmi (an Indian transgender) and Pooja Pande.
Thus through Laxmi’s autobiographical text, the study aims to bring out a deeper understanding of transgenderism and transgenders in India. The article primarily emphasises the following factors: the antiquity that merge with the community, relationship that has to be knit for the transgender community to live and the differences that make the transgender community different - with reference to Laxmi and the duality she possesses.
*Laxmi is the author of Red Lipstick: The Men in My Life but the text is narrated by Pooja Pande
Introduction about Global infectious disease and use of nanotechnology
No full textInfectious diseases, including COVID-19, malaria, tuberculosis, and sexually transmitted diseases (STDs), pose significant threats to global health. Nanotechnology has emerged as a promising tool in the diagnosis, treatment, and prevention of these diseases. This review highlights the applications of nanotechnology in combating infectious diseases. Nanoparticles, such as metallic nanoparticles, liposomes, and quantum dots, have been employed in the detection and treatment of infectious diseases. Nanotechnology-based drug delivery systems have improved the efficacy and reduced the toxicity of antiviral and antibacterial drugs. Additionally, nanotechnology has enabled the development of point-of-care diagnostics and vaccines for infectious diseases. This review provides an overview of the current state of nanotechnology in infectious disease management and highlights its potential to revolutionize the field. By leveraging the unique properties of nanoparticles, nanotechnology can provide innovative solutions for the diagnosis, treatment, and prevention of infectious diseases, ultimately improving global health outcomes.
Keywords: Nanotechnology, Infectious diseases, COVID-19, Malaria, Tuberculosis, HIV/AID
Nanotechnology in Herbal Medicine: A Promising Approach for Enhanced Drug Delivery and Therapeutic Efficacy
No full textNanotechnology has revolutionized the field of herbal medicine by providing a platform for enhanced drug delivery and therapeutic efficacy. The use of nanocarriers and nano formulations has improved the bioavailability and solubility of herbal extracts, allowing for targeted and controlled release of active compounds. This review highlights the potential of nanotechnology in herbal medicine, including the types of nano formulations, methods of preparation, and applications in various diseases. The advantages of nano formulations, such as improved pharmacokinetics and pharmacodynamics are also discussed. Furthermore, the role of computational tools and artificial intelligence in nanotechnology is explored, including their potential to transform drug delivery and disease monitoring. Despite the promising benefits, the drawbacks of nanotechnology, including biocompatibility and toxicity concerns, are also addressed. Overall, nanotechnology has the potential to enhance the therapeutic efficacy and safety of herbal medicines
Keywords: Nanotechnology, Herbal medicine, Nano formulations, Artificial intelligence, Drug deliver
Hepatocellular Carcinoma: A Comprehensive Review of Pathophysiology, Risk Factors, Diagnosis and Treatment Strategies
No full textHepatocellular carcinoma (HCC) is a major cause of death in cirrhosis and the fourth most common cause of cancer-related mortality globally. Chronic liver diseases, such as cirrhosis and viral hepatitis, significantly increase the risk of HCC. Early detection and treatment are vital to improving patient outcomes. HCC development involves complex interactions between liver cells, genetic changes, and environmental factors. Diagnostic approaches include imaging tests, biomarkers, and liquid biopsy. Current treatments comprise surgery, liver transplantation, radiation therapy, and systemic therapies. Preventing HCC through lifestyle changes, such as reducing alcohol intake and maintaining a healthy weight, is crucial. Understanding HCC\u27s molecular mechanisms is essential for developing effective treatments and improving patient outcomes.
Keywords: Hepatocellular carcinoma, Cancer diagnosis, Cirrhosis, chronic liver diseas
