3,997 research outputs found
David Martyn Lloyd-Jones 1899-1981 and twentieth-century evangelicalism.
Full text linkThe purpose of this thesis was to demonstrate the significance of the life and ministry of David Martyn Lloyd-Jones in post-war British evangelicalism and to show that, so far as Protestant churches in England and Wales were concerned, no history of the period can afford to ignore him. It is our contention that despite differences of opinion and self- marginalization Lloyd-Jones was and has remained a major force in evangelical thinking. In order to understand how this developed the thesis has been structured along thematic lines highlighting events, persons and questions. The study begins by setting the stage with a biographical chapter and goes on to examine the kind of impact that Lloyd-Jones's preaching had on Christians of all denominations. He believed preaching to be the greatest need of the day and the position of this thesis is that preaching was Lloyd-Jones's greatest contribution to twentieth- century Christianity. As a preacher he attracted one of London's largest congregations and in chapter three we look at the history and nature of Westminster Chapel comparing it with neighbouring ministries, and establishing the kind of people who went to hear him. Chapters four and five ascertain the factors which shaped Lloyd-Jones's views on the church and show how his Reformed evangelicalism led in a separatist as opposed to an ecumenical direction and finally, to a position which was neither Congregational nor Presbyterian. Our further argument is that while he favoured unity among believers his separatist ecclesiology only exacerbated the situation and left evangelicals more divided than before. Chapters six to eight evaluate Lloyd-Jones's background, the nature of his leadership and the extent of his influence - factors which either shaped or were the outcome of his ministry - and looks at the issues which these questions raise
Nettie Harris Owl
No full textNettie Harris Owl (c. 1872-1923) was a Catawba woman who moved to Cherokee in the 1880s to be with her aunt Susannah Harris Owl. In 1889, Nettie Harris married Lloyd Owl. Along with her Aunt Susannah, Nettie Owl made pottery while living on the Qualla Boundary. Her daughter, Lula Owl Gloyne, confirmed that the two made a good living. As the tourist market for pottery expanded around the turn of the 20th century, Nettie Owl began marking her pottery as Cherokee, using phrases like, “Cherokee Reservation North Carolina 1904” and “Indian Reservation North Carolina 1904.” Although she was a Catawba, she lived in Cherokee with her Cherokee husband and sold through Cherokee outlets
Richard E. Harris
No full textRichard E. Harris
Inducted: 2008
Citation: For the inspired and creative leadership that built both the Boulder Microelectronics Fabrication Facility and the research group that leads the world in superconducting quantum-based measurement and standards systems.
Tenure: 1975-2006
Birth: 1941, Kansas City, Missouri
Education:
University of Rochester, BS (Physics), 1963
University of Illinois, MS (Physics), 1965
University of Illinois, PhD (Physics), 1969
Positions held:
Physicist, Cryoelectronics Section (Boulder), 1975-1982
Group Leader, Cryoelectronic Metrology Group (Boulder), 1982-1993
Division Chief, Electromagnetic Technology Division (Boulder), 1993-2003
Group Leader, Quantum Devices Group (Boulder), 2003-2004
Chief Scientist, Quantum Electrical Metrology Division (Boulder), 2004-2006
Scientist Emeritus, Quantum Devices Group (Boulder), 2006 -
Honors:
US Department of Commerce Silver Medal (1980) and Gold Medal (1989)
Assigned by NIST for one year to IBM Research, Zurich, Switzerland. (1980)
Scientific Advisory Committee for Congress member David Skaggs (1988 – 1992)
Founding member, International Superconductivity Electronics Conference
Co-founder, US Workshop on Superconductive Circuits, Devices and Systems
Review committee for JTEC Study of Superconductivity Research in Japan, National Science Foundation (1989) and appeared on NOVA by the Public Broadcast System
Sigma Xi, elected 1969
Phi Beta Kappa, elected 1962
Memberships:
Elected Board Member, Applied Superconductivity Conference, 1984 – 1990
American Physical Society
Institute of Electronic and Electrical Engineers (senior member)
American Association for the Advancement of Science
Publications:
More than 25 publications and one patent, including:
Lloyd, F. L., Hamilton, C. A., Beall, J. A., Go, D., Ono, R. H., and Harris, R. E., “A Josephson Array Standard at 10 volts,” IEEE Elect. Dev. Letters, EDL-8, 449-450 (1987)
Harris, R. E., Hamilton, C.A., and Lloyd, F. L., “Multiple-quantum Interference Superconducting Analog-to-Digital Converter,” Appl. Phys. Letters 35, 720 (1979)
Havemann, R. H., Hamilton, C. A., and Harris, Richard E., “Photolithographic Fabrication of Lead Alloy Josephson Junctions,” J. Vac. Sci. Technology 15, 392 (1978)
Harris, R. E., Ginsberg, D. M., and Dynes, R. E., “Strong-coupling Correction to the Jump in the Quasiparticle Current of Superconducting Tunnel Junctions,” Phys. Rev. B 14, 993 (1976)
Harris, R. E., “Intrinsic Response Time of a Josephson Tunnel Junction,” Phys. Rev. B 13, 3818 (1976
'Rare and refreshing fruit': Lloyd George's People's Budget
No full textIn its centenary year, Kenneth O. Morgan, explains the profound significance of Lloyd George's People's Budget for our political, social and economic history Copyright (c) 2009 The Author. Journal compilation (c) 2009 ippr.
The Review of Economic Performance and Social Progress 2002: Towards a Social Understanding of Productivity
Full text linkIn this chapter, Richard Harris points out that a traditional view has been that there is an inherent conflict between economic efficiency and social equality, a view neatly summarized in the title of Okun's famous book, Equality and Efficiency: The Big Trade-off (1975). This view gained renewed currency in the policy debates of the 1990s, as commentators contrasted the economic performance of Europe and the U.S. in that decade. This view has been challenged both by cross-national empirical studies and by theoretical advances. Recent research seems to suggest that there is no efficiency-equity trade-off and that social policy and greater equality may actually contribute to higher productivity growth. Richard Harris surveys two streams of recent research that point in this direction. The chapter also examines new theoretical literature, especially the new endogenous growth theory that suggests that increases in inequality can hurt growth.Equity, Efficiency, Productivity, Labour Productivity, Labor Productivity, Growth, Income, Inequality, Equality, Social Policy, Education, Health, Welfare, Redistribution, Social Cohesion, Cohesion, Investment, Innovation, Competition, Living Standards
Structure of the 1,4-Bis(2‘-deoxyadenosin-<i>N</i><sup>6</sup>-yl)-2<i>S</i>,3<i>S</i>-butanediol Intrastrand DNA Cross-Link Arising from Butadiene Diepoxide in the Human N-<i>ras</i> Codon 61 Sequence
No full textThe 1,4-bis(2‘-deoxyadenosin-N6-yl)-2S,3S-butanediol intrastrand DNA cross-link arises from the bis-alkylation of tandem N6-dA sites in DNA by R,R-butadiene diepoxide (BDO2). The oligodeoxynucleotide
5‘-d(C1G2G3A4C5X6Y7G8A9A10G11)-3‘·5‘-d(C12T13T14C15T16T17G18T19C20C21G22)-3‘ contains the BDO2
cross-link between the second and third adenines of the codon 61 sequence (underlined) of the human
N-ras protooncogene and is named the (S,S)-BD-(61-2,3) cross-link (X,Y = cross-linked adenines). NMR
analysis reveals that the cross-link is oriented in the major groove of duplex DNA. Watson−Crick base
pairing is perturbed at base pair X6·T17, whereas base pairing is intact at base pair Y7·T16. The cross-link
appears to exist in two conformations, in rapid exchange on the NMR time scale. In the first conformation,
the β-OH is predicted to form a hydrogen bond with T16 O4, whereas in the second, the β-OH is predicted
to form a hydrogen bond with T17 O4. In contrast to the (R,R)-BD-(61-2,3) cross-link in the same sequence
(Merritt, W. K., Nechev, L. V., Scholdberg, T. A., Dean, S. M., Kiehna, S. E., Chang, J. C., Harris, T.
M., Harris, C. M., Lloyd, R. S., and Stone, M. P. (2005) Biochemistry 44, 10081−10092), the anti-conformation of the two hydroxyl groups at Cβ and Cγ with respect to the Cβ−Cγ bond results in a
decreased twist between base pairs X6·T17 and Y7·T16, and an approximate 10° bending of the duplex.
These conformational differences may account for the differential mutagenicity of the (S,S)- and (R,R)-BD-(61-2,3) cross-links and suggest that stereochemistry plays a role in modulating biological responses
to these cross-links (Kanuri, M., Nechev, L. V., Tamura, P. J., Harris, C. M., Harris, T. M., and Lloyd,
R. S. (2002) Chem. Res. Toxicol. 15, 1572−1580)
Structure of the 1,4-Bis(2‘-deoxyadenosin-<i>N</i><sup>6</sup>-yl)-2<i>S</i>,3<i>S</i>-butanediol Intrastrand DNA Cross-Link Arising from Butadiene Diepoxide in the Human N-<i>ras</i> Codon 61 Sequence
No full textThe 1,4-bis(2‘-deoxyadenosin-N6-yl)-2S,3S-butanediol intrastrand DNA cross-link arises from the bis-alkylation of tandem N6-dA sites in DNA by R,R-butadiene diepoxide (BDO2). The oligodeoxynucleotide
5‘-d(C1G2G3A4C5X6Y7G8A9A10G11)-3‘·5‘-d(C12T13T14C15T16T17G18T19C20C21G22)-3‘ contains the BDO2
cross-link between the second and third adenines of the codon 61 sequence (underlined) of the human
N-ras protooncogene and is named the (S,S)-BD-(61-2,3) cross-link (X,Y = cross-linked adenines). NMR
analysis reveals that the cross-link is oriented in the major groove of duplex DNA. Watson−Crick base
pairing is perturbed at base pair X6·T17, whereas base pairing is intact at base pair Y7·T16. The cross-link
appears to exist in two conformations, in rapid exchange on the NMR time scale. In the first conformation,
the β-OH is predicted to form a hydrogen bond with T16 O4, whereas in the second, the β-OH is predicted
to form a hydrogen bond with T17 O4. In contrast to the (R,R)-BD-(61-2,3) cross-link in the same sequence
(Merritt, W. K., Nechev, L. V., Scholdberg, T. A., Dean, S. M., Kiehna, S. E., Chang, J. C., Harris, T.
M., Harris, C. M., Lloyd, R. S., and Stone, M. P. (2005) Biochemistry 44, 10081−10092), the anti-conformation of the two hydroxyl groups at Cβ and Cγ with respect to the Cβ−Cγ bond results in a
decreased twist between base pairs X6·T17 and Y7·T16, and an approximate 10° bending of the duplex.
These conformational differences may account for the differential mutagenicity of the (S,S)- and (R,R)-BD-(61-2,3) cross-links and suggest that stereochemistry plays a role in modulating biological responses
to these cross-links (Kanuri, M., Nechev, L. V., Tamura, P. J., Harris, C. M., Harris, T. M., and Lloyd,
R. S. (2002) Chem. Res. Toxicol. 15, 1572−1580)
Pathological replication in cells lacking RecG DNA translocase
Full text linkThis is an open access article, shared under a Creative Commons licence. Copyright © 2009 The Authors.Little is known about what happens when forks meet to complete DNA replication in any organism. In this study we present data suggesting that the collision of replication forks is a potential threat to genomic stability. We demonstrate that Escherichia coli cells lacking RecG helicase suffer major defects in chromosome replication following UV irradiation, and that this is associated with high levels of DNA synthesis initiated independently of the initiator protein DnaA. This UV-induced stable DNA replication is dependent on PriA helicase and continues long after UV-induced lesions have been excised. We suggest UV irradiation triggers the assembly of new replication forks, leading to multiple fork collisions outside the terminus area. Such collisions may generate branched DNAs that serve to establish further new forks, resulting in uncontrolled DNA amplification. We propose that RecG reduces the likelihood of this pathological cascade being set in motion by reducing initiation of replication at D- and R-loops, and other structures generated as a result of fork collisions. Our results shed light on why replication initiation in bacteria is limited to a single origin and why termination is carefully orchestrated to a single event within a restricted area each cell cycle.The Medical Research Council and the Leverhulme Trust
Relazioni ed entità emergenti: da Broad e Lloyd Morgan a Kim
No full textThe author tries to argue that J. Kim’s exclusion argument is not incompatible with the acceptance of a certain form of ontological emergence and that C. D. Broad’s and C. Lloyd Morgan’s doctrines should be actually taken as weakly emergentist doctrines – even if Lloyd Morgan’s doctrine can be also interpreted in strongly emergentist terms. The crucial point of such versions of emergentism – what grounds the very occurrence of emergence – lies in external relations’ being involved in the emergence bases. First, the author distinguishes between weak and strong ontological emergence and between internal and external relations. Secondly, he reconstructs Broad’s and Lloyd Morgan’s doctrines. Thirdly, he examines Kim’s exclusion argument and he argues for the general conclusion of the article. In conclusion, insofar as physicalists accept that non-physical entities can depend in special ways on physical ones (e.g., by involving irreducible, external relations in the dependence bases), they can also accept certain forms of ontological emergence
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