1,721,152 research outputs found
Patch test con materiali forniti dal paziente
No full textPatch testing with standard series and/or additional series allows the identification of the substances responsible for allergic contact dermatitis in 40-50% of patients. This percentage can be increased by performing patch tests with materials supplied by the patient as such or treated in various ways. The method is not without difficulties and it is possible to observe falsely positive or negative reactions, and the ability to induce new sensitizations. It's necessary to standardize as much as possible the method of the test
La gestione del paziente con sospetta allergia a famaci topici e sistemici : come procedere nella esecuzione dei test
No full text
Recalcitrant severe hidradenitis suppurativa successfully treated with cyclosporine A.
No full textHidradenitis suppurativa therapy is usually complex and unsatisfactory. Systemic antibiotics, isotretinoin and tumor necrosis factor-alfa are used with relapses following discontinuation. The use of CyA in hidradenitis suppurativa, effective and well tolerated, has rarely been reported in the literature. A 52-year-old male, with an 8-year history of recurrent inflammatory nodular and cystic lesions, discharging sebaceous and seropurulent material associated with sinus and fistula occurrence of the anogenital region, groins, and right axilla, is reported. Several antibiotic therapies, oral isotretinoin, infliximab and etanercept had been ineffective or temporarily effective. The Dermatology Life Quality Index showed a severe impairment of life quality.
Oral cyclosporine A was started and after 2 months an improvement of lesions was observed. During the last 2 years cyclosporine A has been well tolerated, with marked reduction in inflammation and suppuration and significant improvement in the quality of life of the patient
Aphthous stomatitis induced by piroxicam
No full textThe most frequent adverse mucocutaneous reactions induced by piroxicam is photodermatitis, but maculopapular or lichenoid eruptions, urticaria, erythema multiforme, toxic epidermal necrolysis, and pruritus can occur. On the other hands, among the undesirable reactions affecting the oral mucosa from systemic medication, erosive and ulcerative stomatitis is frequent, mainly caused by antihypertensives and antiangina drugs. Authors describe a 49-year-old man with an acute aphthous stomatitis. The erosions and ulcers, localized on the lateral borders of the tongue and oral mucosa, were very painful, circular and sharply delimited, 2 to 3 mm in diameter, with a red border, and covered by a yellowish white pseudomembrane. They were associated with dysphagia and sialorrhea. The patient reported occasional low back pain treated orally with piroxicam. Therefore patch and prick test with piroxicam were negative. An oral provocation test was performed with increasing doses of piroxicam. Aphthous stomatitis relapsed 48 hours from the last dose.
This report emphasizes the role of exposure test in diagnosis of adverse mucocutaneous reactions, mainly when the suspected drugs are nonsteroidal anti-inflammatory drugs. In these patients, an exposure test should be performed only in the hospital and in specialized centers equipped for emergency and not in patients with severe adverse mucocutaneous reactions, such as anaphylaxis, angioedema, erythema multiforme, and Stevens-Johnson syndrome
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