451 research outputs found
Microsurgical management of cranial dural arteriovenous fistulas: Treating the “Sheep in Wolf's clothing”? – Three decades of experience and lessons learned
No full textSekretion des Stresshormons Copeptin im Rahmen der insulininduzierten Hypoglykämie : eine klinisch-prospektive Studie
No full textCopeptin, the c-terminal peptide fragment of pre-pro-vasopressin, is a sensitive surrogate marker for circulating vasopressin. Vasopressin stimulating ACTH secretion under stress conditions has been disputed for years. However, the extent of such an interaction is not fully understood. Is was our objective to examine the copeptin secretion under stress conditions as well as to investigate a suspected stress-related interaction of the HPA axis and the vasopressinergic axis in humans. In a prospective clinical trial 118 patients with clinically suspected hypopituitarism were assessed during insulin-induced hypoglycaemia. Symptomatic hypoglycaemia was safely induced and led to a rapid increase of copeptin secretion in all patients. As expected patients with central diabetes insipidus (n=12) had lower basal and stimulated copeptin levels. Patients with intact pituitary function (n=42) had significantly higher copeptin peak levels than patients with hypopituitarism (n=64). Furthermore there was a correlation between copeptin and cortisol levels. This correlation was more intense in women than in men. A correlation between adrenaline and copeptin levels was neither found in the whole study group nor in men and women separately. The copeptin secretion could not be explained by the increase of growth hormone. There was no confounding by age or body mass index. Our findings support a synergism between HPA axis and vasopressinergic axis under stress conditions. We observed a striking gender difference in the vasopressinergic response to stress
Hirnchirurgische Eingriffe bei Temporallappenepilepsie in historischer und ethischer Perspektive
No full textAnalyse und Bewertung nutzungsorientierter Risiken mit dem Ziel einer Workflowoptimierung im neurochirurgischen Operationssaal
No full textPrimary intermidate grade melanocytic tumour of the medulla oblongata causing recurrent brain stem haemorrhage
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The spine as the largest link chain of the human body and its response to static and dynamic factors
No full textBeeinträchtigung des Sehvermögens durch Meningeome des Tuberculum sellae prä- und postoperativ
No full text<<Die>> Rolle von Caveolin-3 in astrozytären Gliomen und dessen Nutzung als prognostischer und/oder therapeutischer Biomarker
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