256 research outputs found
Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer
No full textR Data files associated with datasets generated in our study "Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer". These include a Seurat object holding integrated scRNA-sequencing data for fibroblasts isolated from multiple human lung cancer datasets (IntegratedFibs_Zenodo.Rdata); a dataframe holding histo-cytometry results from multiplexed immunohistochemistry (mxIHC) analysis performed on whole human lung cancer tissue sections; and additional datafiles required to reproduce the paper's figures. Full details and code demonstrating their use in our analysis are provided on Github (https://github.com/cjh-lab/NCOMMS_NSCLC_scFibs).</span
Improved understanding of NSCLC immunotherapy response mechanisms from single-cell analysis
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Reconciling Versioning and Context in Hypermedia Structure Servers
No full textContextual structure servers and versioning servers share a similar goal in allowing different views on a stored structure according to the viewer’s perspective. In this paper we argue that a generic contextual model can be used to facilitate versioning. In order to prove our hypothesis we have drawn on our experiences with OHP-Version to extend FOHM’s contextual model
Disciplining the Spectator: Subjectivity, the Body and Contemporary Spectatorship
No full textIn this thesis the author argues that although questions of the spectator’s corporeal engagement with film are much neglected by film theory, the body is nevertheless a central term within contemporary cinema, in its mode of address, as a locus of anxiety in media effects debate, and as site of disciplinary practices. And while the thesis begins by demonstrating both the socially and historically constructed nature of spectatorship, and the specific practices that work to create contemporary cinema’s corporeal address, the latter half of the dissertation devotes itself to revealing the regulatory implications of this physical address. That is, the author shows that cinema’s perceived capacity of affect the body of the spectator is a profound source of cultural anxiety. But more importantly, through an analysis of the films Funny Games, Irréversible, Wolf Creek, and the genre of ‘torture porn’ more generally, what is revealed in these final chapters is that the regulation of cinema in the contemporary era is less a question of the institutionalised censorship of texts, and more a question of regulating the ‘self’. In this respect, the author demonstrates the specific disciplinary practices that attempt to present the problem of violent, and sexually violent, imagery not as a textual issue per se, but a question of the formation of appropriate spectatorial relations. Moreover, this study begins the process of teasing out the ways in which the contemporary spectator is induced to see the problem of media violence as one that can be resolved through what
Foucault would term, techniques of the self
Inertia in infrastructure development : some analytical aspects, and reasons for inefficient infrastructure choices
No full textThis paper uses some simple conceptual models to draw out various implications of infrastructure investments with long lifetimes for the ability of societies to reduce their future greenhouse gas emissions. A broad range of such investments, related both to energy supply and demand systems, may commit societies to high and persistent levels of greenhouse gas emissions over time, that are difficult and costly to change once the investments have been sunk. There are, the author argues, several strong reasons to expect the greenhouse gas emissions embedded in such investments to be excessive. One is that infrastructure investment decisions tend to be made on the basis of (current and expected future) emissions prices that do not fully reflect the social costs of greenhouse gas emissions resulting from the investments. A second, related, set of reasons are excessive discounting of future project costs and benefits including future climate damages, and a too-short planning horizon for infrastructure investors. These issues are illustrated for two alternative cases of climate damages, namely with the possibility of a"climate catastrophe,"and with a sustained increase in the marginal global damage cost of greenhouse gas emissions.Climate Change Economics,Energy Production and Transportation,Climate Change Mitigation and Green House Gases,Transport Economics Policy&Planning,Environment and Energy Efficiency
Beyond black and white : affirmative action in America
No full textModerator, Charles J. Ogletree ; panelists, Ward Connerly, Angela Walker, Ruth J. Simmons, Ann Coulter, Frank D. Riggs, Ann F. Lewis, Antonia Hernandez, Suzan Shown Harjo, Diane Chin, Robert L. Woodson, Sr., Christopher Edley, Jr., Judge Jon O. Newman, John R. Strangfeld, Tamar Jacoby, Lt. Gen. Julius W. Becton, Jr. Editor, Jonathan Fein.All sides of the affirmative action issue have targeted the same goal: ending racism of all types. But do opportunities for some have to come at the expense of others? In this Fred Friendly Seminar moderated by Harvard Law School's Charles Ogletree, a what-if scenario revolves around a university's efforts to enroll a diverse student body of qualified candidates. Panelists include Ward Connerly, proponent of California's Proposition 209; Christopher Edley, Jr., author of Not All Black & White: Affirmative Action, Race, and American Values; Julius Becton, Jr., former head of Washington, D.C.'s public schools; Ruth Simmons, president of Smith College; and policy activists from the African-American, Asian, Native American, and Latino communities
Fostering land use dialog : community preservation as a growth management strategy in Massachusetts
No full textThesis (M.C.P.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning, 2004.Includes bibliographical references (p. 124-128).This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.The Community Preservation Initiative (CPI) was an innovative attempt by the Massachusetts state government to stimulate discussion about land use and growth management at the local level. Based on land use and zoning information, CPI relied on geographic information systems (GIS) to model a potential development scenario for each of the 351 municipalities in the state. The process for generating these buildout maps purposefully involved officials at local, regional, and state levels. This thesis examines the success of the CPI process in evolving land use dialog within and between communities, and amongst planners at all three levels of government. Town planners in two different metropolitan regions of Massachusetts - Boston and Springfield - were interviewed about CPI's impact on local land use discussions. This research was supplemented by interviews with other regional planners and CPI staff. The results suggest that while CPI may eventually lead to changes in local land use, in the short term few changes have occurred to the dialog on growth management in the state. The results of this investigation should aid state and regional decision-makers in determining what future policies and approaches are needed to promote smart growth and regional planning in Massachusetts and other states.by Christopher J. Hodges.M.C.P
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Artistic Expression in Music and Poetry
No full textThis paper delineates meaningful relationships of passions, emotions, feelings, affections, nuances and aural perceptions of expressions and utterances, for understanding human artistic possibilities historically and contemporarily in the fraternal arts of music and poetry, with reference to sounds, silences, sequences, rhythms, rhymes, repetitions, retards, accelerations, tempos, harmonies, melodies, forms, etc., in four poetic and three musical compositions uniquely created by its author
Changing patterns in vocational education
No full textOne of the long standing issues in education development has been productive job training in rapidly changing economies. The argument has been made that vocational secondary schools are not well equipped for this task. Although vocational and academic schooling often result in similar levels of education and employment, the higher costs of the vocational schooling makes it a less attractive alternative. In the past 23 years of Bank lending for vocational education and training, there has been a clear shift away from vocational secondary schools toward various forms of training, outside the formal education system. Although investment has been shifting into nonformal training, secondary education is in need of new directions. Diversified secondary schools have not provided that direction, leaving questions about how secondary schools might meet social objectives cost effectively.Tertiary Education,Teaching and Learning,Gender and Education,Primary Education,Curriculum&Instruction
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