1,277 research outputs found
Recollections of Clement C. Moore, author of "A Visit from St. Nicholas"
No full textIncludes 2 poems by Clement C Moore, including "A Visit from St. Nicholas." Part of the Nancy H. Marshall Night before Christmas collection. Swem Library copy includes and undated letter about the book by Margaret N.C. Bradley, niece of the author
Studies of glutathione transferase P1-1 bound to a platinum(IV)-based anticancer compound reveal the molecular basis of its activation
No full textPlatinum-based cancer drugs, such as cisplatin, are highly effective chemotherapeutic agents used extensively for the treatment of solid tumors. However, their effectiveness is limited by drug resistance, which, in some cancers, has been associated with an overexpression of pi class glutathione S-transferase (GST P1-1), an important enzyme in the mercapturic acid detoxification pathway. Ethacraplatin (EA-CPT), a trans-PtIV carboxylate complex containing ethacrynate ligands, was designed as a platinum cancer metallodrug that could also target cytosolic GST enzymes. We previously reported that EA-CPT was an excellent inhibitor of GST activity in live mammalian cells compared to either cisplatin or ethacrynic acid. In order to understand the nature of the drug–protein interactions between EA-CPT and GST P1-1, and to obtain mechanistic insights at a molecular level, structural and biochemical investigations were carried out, supported by molecular modeling analysis using quantum mechanical/molecular mechanical methods. The results suggest that EA-CPT preferentially docks at the dimer interface at GST P1-1 and subsequent interaction with the enzyme resulted in docking of the ethacrynate ligands at both active sites (in the H-sites), with the Pt moiety remaining bound at the dimer interface. The activation of the inhibitor by its target enzyme and covalent binding accounts for the strong and irreversible inhibition of enzymatic activity by the platinum complex.Lorien J. Parker, Louis C. Italiano, Craig J. Morton, Nancy C. Hancock, David B. Ascher, Jade B. Aitken, Hugh H. Harris, Pablo Campomanes, Ursula Rothlisberger, Anastasia De Luca, Mario Lo Bello, Wee Han Ang, Paul J. Dyson and Michael W. Parke
Multi-hazard risk report for Tillamook County, Oregon, including the cities of Bay City, Garibaldi, Manzanita, Nehalem, Rockaway Beach, Tillamook, and Wheeler and the unincorporated communities of Bayside Gardens, Neskowin, Oceanside, Netarts, and Pacific City
No full textby Matt C. Williams and Nancy C. Calhoun.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (pages 53-56).Mode of access: Internet from the Oregon Government Publications Collection.Text in English
Multi-hazard risk report for Morrow County, Oregon, including the cities of Boardman, Heppner, Ione, Irrigon, and Lexington
No full textby Matt C. Williams and Nancy C. Calhoun.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (pages 35-37).Mode of access: Internet from the Oregon Government Publications Collection.Text in English
Remembering Carlton Rochell
No full textDr. Carlton C. Rochell, who served as Dean of Libraries at New York University (NYU) from 1976–1999, died in Nashville, TN, on Dec. 23 at the age of 85 after a brief illness.
Rochell came to NYU shortly after the University combined 38 separate collections into the dramatic new Philip Johnson-designed Elmer Holmes Bobst Library. He managed and integrated those disparate collections by introducing innovative technological solutions that became models for the nation. During his tenure, the library's collection size doubled, the book endowment grew 1,200 percent, and circulation of books and materials expenditures both tripled. Rochell asserted a leadership role that transformed the NYU Libraries into a world-class resource
Safe/Brave Spaces: Engaging Future Citizens through School Libraries
No full textAlthough schools have not routinely taught civics since the 1970s, a burgeoning movement to incorporate such studies into the curriculum is taking shape around the country. This movement opens doors for school librarians to engage students in new and innovative ways, bringing a diversity of future citizens safe (and brave) spaces where they have a voice, listen to each other, and share interests, concerns, and decision-making. If school librarians seize this important moment, they will create new opportunities for teaching the kind of critical thinking skills they have embraced for years. Undoubtedly, school libraries are well positioned to become critical actors in the kind of civic learning promoted by Levine and Kawashima-Ginsberg, just as they have traditionally prepared students to succeed in college and careers. But they must incorporate that 3rd “C”—citizenship, to ensure that tomorrow’s adults take an active role in the collective life of their communities and country, and not just their own individual pursuits. School libraries can make a marked difference in the civic mission of schools by reimagining learning spaces, convening civil public forums, fostering civic literacy, and building civic partnerships.Contract permits posting on repository. Negotiated for this
Multi-hazard risk report for the City of Cottage Grove, Oregon
No full textby Matt C. Williams and Nancy C. Calhoun.Title from PDF cover (viewed on April 4, 2023).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (pages 28-29).Funding provided by the Oregon Department of Land Conservation and Development.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
Geographic information system-based toolbox for improved efficiency and precision of landslide inventory mapping
No full textby Jon J. Franczyk, William J. Burns, and Nancy C. Calhoun.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (page 19).Mode of access: Internet from the Oregon Government Publications Collection.Text in English
Protocol for channelized debris flow susceptibility mapping
No full textby William J. Burns, Jon J. Franczyk, and Nancy C. Calhoun.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (pages 69-72).Mode of access: Internet from the Oregon Government Publications Collection.Text in English
Tool for use in semi-automatic landslide mapping
No full textReport -- Maps.by Michael Bunn, Ben A. Leshchinsky, Michael J. Olsen, Nancy C. Calhoun, Jon J. Franczyk, and William J. Burns.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (pages 39-41).Mode of access: Internet from the Oregon Government Publications Collection.Text in English
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