24 research outputs found
Echocardiography in Transfusion Dependent Beta Thalassaemia Major Egyptian Children: Correlation with Thyroid Function Status and Ferritin Level
No full textImpact of the follicular fluid Coenzyme Q10 level in women undergoing intracytoplasmic sperm injection (ICSI) on the pregnancy rate
No full textBackground: The most crucial problem with in vitro fertilization (IVF) cycles is still oocyte quality. The women age and the condition of their ovarian reserve are the primary determinants of oocyte quality.
Objectives: to assess the effects of intracytoplasmic sperm injection (ICSI) on the result of pregnancies and the coenzyme Q10 (CoQ10) value in follicular fluid (FF) in the women who had the procedure.
Patients and methods: this cohort investigation was conducted on 81 infertile patients (age between 20-42 years, both normal or poor responders’ patients and patients with unexplained infertility) who underwent ICSI cycles.
Results: patients were divided into two groups: the pregnant group (n= 32) and the non-pregnant group (n= 49).There was a statistically insignificant difference in antral follicle count (AFC), number of retrieved oocytes, number of embryos, number of metaphase II (MII) oocytes, and maturation index between pregnant and non-pregnant females. CoQ10 level in FF was substantially greater in pregnant than non-pregnant females.
Conclusion: FF CoQ10 levels were positively correlated with eventual embryo quality and rates of conception. Our findings might be in favour of CoQ10 supplementation in women undergoing IVF for enhancement of the ovum and embryo quality
Tumor expression of Nectin-4 as a prognostic marker in breast cancer
No full textBackground: Identification of new molecular tumor associated biomarkers is the most important current challenge in cancer research. Nectin-4 is one of the Nectin glycoproteins, which are cell adhesion molecules have been involved in tumor biology.
Objectives: The objective was to evaluate Nectin-4 expression by immunohistochemistry (IHC) as a prognostic tumor marker in breast cancer (BC).
Patients and Methods: This study was carried out on 100 female patients with BC. Their ages ranged between 29 and 67 years, with a mean of 41.3 years. Fifty other age-matched patients, subjected to reduction mammoplasty, served as controls. Data collected prospectively included patient demographics and tumor characteristics, including histopathological type and grade, IHC for Nectin-4 expression, estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER2-Neu). Patients were regularly followed-up for 2 years, recording loco-regional recurrence, distant metastasis, and mortality.
Results: Nectin-4 expression by IHC was detected in 62% of BC patients, but in none of the tumor-free controls (P = 0.0001). Nectin-4 expression showed a statistically significant positive correlation with higher tumor grade (P = 0.003) and axillary lymph node involvement (P = 0.0001), but not with increasing tumor size (P = 0.273). It had a significant inverse correlation with ER and PR, and a significant positive correlation with HER2-Neu (P = 0.0001). Furthermore, there was a significant correlation between Nectin-4 expression and the development of distant metastases (P = 0.014), local recurrence (P = 0.046), and mortality (P = 0.049).
Conclusions: Nectin-4 is a highly recommended biomarker for predicting progression and prognosis of BC. [Arch Clin Exp Surg 2015; 4(4.000): 178-184
Effect of Designing and Implementing Nursing Guidelines on Nurses' Performance in Caring Women with Ectopic Pregnancy
No full textContext: Ectopic pregnancy is a condition presenting a significant health problem for women of the childbearing period. Ectopic
pregnancy remains one of the primary causes of maternal mortality.
Aim: The study aimed to evaluate the effect of nursing guidelines for improving maternity nurses' performance regarding ectopic pregnancy.
Methods: A quasi-experimental design was used to achieve the aim of the study. The study was conducted at Obstetrics and Gynecology Department at Benha University Hospital. A convenient sample of all nurses (90 nurses) working in Obstetrics and Gynecology departments at Benha university hospital. Tools of data collection included a structured self-administered questionnaire to assess nurses' knowledge regarding ectopic pregnancy, an observational checklist to evaluate nursing practice regarding ectopic pregnancy before and after implementing the nursing guidelines.
Results: 78.9% of the studied nurses had a total incorrect knowledge preprogram, which improved to 88.9% of them and had correct knowledge post-program. The study also shows that 47.2% of the studied nurses had unsatisfactory total practice score preprogram, which improved to 54.4% of the studied nurses who had high satisfactory total practice post-program. There was a highly statistically significant difference before and after nursing guidelines of the studied nurses’ knowledge and practice regarding ectopic pregnancy (P ≤ 0.001).
Conclusion: The study concluded that nursing guidelines positively affect the nurses' performance in terms of their knowledge and practice regarding ectopic pregnancy. The study recommended that simple guidelines regarding ectopic pregnancy nursing care should be distributed to nurses in the emergency obstetrics department to standardize and optimize nursing care provided to women with ectopic pregnancies. Continuous refreshment courses and follows up programs for nurses regarding ectopic pregnancy
Feasibility and ability of laparoscopy to predict respectability in ovarian cancer: Review article
No full textBackground: Epithelial ovarian cancer is one of the leading causes of death in gynecological malignancies and the seventh most common cancer in the world among women. Aim and objectives: The main aim of this study was to study the feasibility and ability of laparoscopy in predicting optimum respectability in cases of ovarian cancer. Conclusion: Laparoscopy has an effective feasibility and ability in predicting optimum respectability in cases of ovarian cancer. As laparoscopy before starting treatment was a reliable additional diagnostic tool in predicting result of PDS, this can prevent laparotomies. This will optimize treatment for the individual patient
The clinical musculoskeletal ultrasonography: Egyptian guidelines for structured musculoskeletal ultrasound scanning and reporting
No full textAbstract Background The aim of this work is to set up the standards for performing musculoskeletal ultrasound scans and reporting as an additional procedure in the rheumatology setting. We used two rounds of the Delphi approach to get the consensus on a musculoskeletal ultrasound reporting. Results Fifteen expert panels had completed the two rounds of surveys. After the end of round two, eighteen recommendations distributed upon eight domains were released. The percentage of the agreement on the recommendations was 93.3 to 100 %. All eighteen key questions were answered at the end of the second round with agreement. Conclusion A musculoskeletal ultrasound report template has been developed by this study, based on outcomes of a Delphi process, by an international participants’ panel. All domains met the 80% voting threshold set in this work. The reporting template can be used for both clinical research as well as standard practice to provide guidance and standardize the musculoskeletal ultrasound reporting
Impact on inflammatory mediators (TNF-, IL-1, NF-κβ, collagen I, CTGF and hydroxyproline) in liver tissue.
No full textImpact on inflammatory mediators (TNF-, IL-1, NF-κβ, collagen I, CTGF and hydroxyproline) in liver tissue.</p
Effect of RBO on tissue levels of GSH and MDA in TAA-induced liver fibrosis in rats.
No full textControl rats, treated with saline; TAA rats, treated with thioacetamide (100 mg/kg; three times per week for 2 weeks, ip); RBO rats, treated with TAA and RBO (0.2 and 0.4 mL/rat; daily for 2 weeks, po) and silymarin (100 mg/kg, po). All data are presented as Mean± SEM, (n = 6). a P≤0.05 was assumed to denote statistical significance compared to the negative control, b P≤0.05 was assumed to denote statistical significance compared to TAA group. TAA, Thioacetamide; RBO, Rice bran oil; GSH, Reduced glutathione; MDA, Malondialdehyde.</p
Effect of RBO on TGF-β1, FAK and α-SMA in TAA-induced liver fibrosis in rats.
No full textControl rats, treated with saline; TAA rats, treated with thioacetamide (100 mg/kg; three times per week for 2 weeks, ip); RBO rats, treated with TAA, RBO (0.2 and 0.4 mL/rat; daily for 2 weeks, po) and silymarin (100 mg/kg, po). All data are presented as Mean± SEM, (n = 6). a P≤0.05 was assumed to denote statistical significance compared to the negative control, b P≤0.05 was assumed to denote statistical significance compared to TAA group. TAA, Thioacetamide; RBO, Rice bran oil; TGF-β1, Transforming growth factor beta; FAK, Focal adhesion kinase; α-SMA, Alpha-Smooth Muscle Actin.</p
