1,600,546 research outputs found
15 años de alfabetización en información: investigación internacional recogida en LISA, ERIC y SSCI entre 1990 y 2005
Full text linkSe presenta el alcance de la investigación internacional en Alfabetización en Información (ALFIN)entre los años 1990 y 2005 a partir del análisis de las publicaciones recogidas en tres de las principales bases de datos internacionales que cubren el tema: LISA, ERIC y SSCI. Se ha analizado la actividad investigadora del periodo, la tipología documental, idioma, autores más productivos y revistas más
utilizadas. Por otro lado, y a través de una metodología de análisis de contenido, se han categorizado los trabajos de los diez autores más productivos, encontrando en ellos la progresión temática lógica de un área en desarrollo. Otros resultados indican el predominio de trabajos anglosajones así como el incremento exponencial de la producción a lo largo del periodo estudiado.Publicad
A Lightweight and Cost-Effective 3D Omnidirectional Depth Sensor Based on Laser Triangulation
Full text linkIn this paper, we propose a new lightweight and cost-effective 3D omnidirectional depth sensor based on laser triangulation in order to ensure a wide field of view (FOV) while achieving portability and affordability. The proposed sensor is tiny palm-sized and hence easily installed even on small moving objects, which is largely composed of a structured light-based 2D sensor and a rotating motor for creating a full 360 degree horizontal FOV, thus providing a 3D omnidirectional sensing capability. The structured light-based 2D sensor is specially designed to maximize the vertical FOV by employing a fisheye camera and a laser beam passing through two cylindrical lenses for projecting a line onto a surface. From the rotational movement of the 2D sensor due to the mounted motor, its surroundings are scanned by extracting the corresponding 3D omnidirectional depth information from laser triangulation. The actual implementation is carried out to examine the technical feasibility of realizing the proposed 3D omnidirectioanl depth sensor. It turns out that the proposed depth sensor covers over 97% area of its surrounding sphere. It is also observed through experiments that the proposed 3D omnidirectional depth sensor has similar accuracy to that of a Velodyne HDL-32, 32-channel light detection and ranging (LIDAR) sensor, at a range of 5 m to 6 m while providing much wider vertical FOV and higher vertical resolution.11Ysciescopu
Unified approach for universal quantum gates in a coupled superconducting two-qubit system with fixed always-on coupling
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Rapid optimization of working parameters of microwave-driven multilevel qubits for minimal gate leakage
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Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance
No full textThe mechanism of FFA-induced insulin resistance is not fully understood. We have searched for effector molecules(s) in FFA-induced insulin resistance. Palmitic acid (PA) but not oleic acid (OA) induced insulin resistance in L6 myotubes through C-Jun N-terminal kinase (JNK) and insulin receptor substrate 1 (IRS-1) Ser307 phosphorylation. Inhibitors of ceramide synthesis did not block insulin resistance by PA. However, inhibition of the conversion of PA to lysophosphatidylcholine (LPC) by calcium-independent phospholipase A(2) (iPLA(2)) inhibitors, such as bromoenol lactone (BEL) or palmitoyl trifluoromethyl ketone (PACOCF(3)), prevented insulin resistance by PA. iPLA(2) inhibitors or iPLA(2) small interfering RNA (siRNA) attenuated JNK or IRS-1 Ser307 phosphorylation by PA. PA treatment increased LPC content, which was reversed by iPLA(2) inhibitors or iPLA(2) siRNA. The intracellular DAG level was increased by iPLA(2) inhibitors, despite ameliorated insulin resistance. Pertussis toxin (PTX), which inhibits LPC action through the G-protein coupled receptor (GPCR)/G alpha(i), reversed insulin resistance by PA. BEL administration ameliorated insulin resistance and diabetes in db/db mice. JNK and IRS-1Ser307 phosphorylation in the liver and muscle of db/db mice was attenuated by BEL. LPC content was increased in the liver and muscle of db/db mice, which was suppressed by BEL. These findings implicate LPC as an important lipid intermediate that links saturated fatty acids to insulin resistance.-Han, M. S., Y-M. Lim, W. Quan, J. R. Kim, K. W. Chung, M. Kang, S. Kim, S. Y. Park, J-S. Han, S-Y. Park, H. G. Cheon, S. D. Rhee, T-S. Park, and M-S. Lee. Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance. J. Lipid Res. 2011. 52: 1234-1246
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