384 research outputs found
GLI Pathogenesis-Related 1 Functions as a Tumor-Suppressor in Lung Cancer
No full textBackground: GLI pathogenesis-related 1 (GLIPR1) was originally identified in glioblastomas and its expression was also found to be down-regulated in prostate cancer. Functional studies revealed both growth suppression and proapoptotic activities for GLIPR1 in multiple cancer cell lines. GLIPR1s role in lung cancer has not been investigated. Protein arginine methyltransferase 5 (PRMT5) is a protein arginine methyltransferase and forms a stoichiometric complex with the WD repeat domain 77 (WDR77) protein. Both PRMT5 and WDR77 are essential for growth of lung epithelial and cancer cells. But additional gene products that interact genetically or biochemichally with PRMT5 and WDR77 in the control of lung cancer cell growth are not characterized. Methods: DNA microarray and immunostaining were used to detect GLIPR1 expression during lung development and lung tumorigenesis. GLIPR1 expression was also analyzed in the TCGA lung cancer cohort. The consequence of GLIPR1 on growth of lung cancer cells in the tissue culture and lung tumor xenografts in the nude mice was observed. Results: We found that GLIPR1 expression is negatively associated with PRMT5/WDR77. GLIPR1 is absent in growing epithelial cells at the early stages of mouse lung development and highly expressed in the adult lung. Expression of GLIPR1 was down-regulated during lung tumorigenesis and its expression suppressed growth of lung cancer cells in the tissue culture and lung tumor xenografts in mice. GLIPR1 regulates lung cancer growth through the V-Erb-B avian erythroblastic leukemia viral oncogene homolog 3 (ErbB3) Conclusions: This study reveals a novel pathway that PRMT5/WDR77 regulates GLIPR1 expression to control lung cancer cell growth and GLIPR1 as a potential therapeutic agent for lung cance
Sol-gel synthesis of Yb-doped NaLu(WO4)2 films
No full textAbstractDense and (001)-textured thin films with composition NaLu1−xY bx(WO4)2 (x=0.01–0.5) have been prepared by multiple spincoating deposition of sol-gel synthesized solutions, followed by a sintering thermal annealing. Films with thickness above 1 μm are transparent and have photoluminescence properties similar to those of isostructural single crystals. The role of Yb composition, film thickness and purity of the raw Y b2O3 used on the Y b3+ fluorescence efficiency are discussed in relation to the application of the films as diode laser pumped solid-state laser media
Sol-gel synthesized NaLu<sub>1-x</sub>Yb<sub>x</sub>(WO<sub>4</sub>)<sub>2</sub> heteroepitaxial films for laser applications
No full textAbstractNaLu1-xYbx(WO4)2 films have been prepared by spin coating of sol-gel precursor solutions and thermal annealing between 400 and 800 °C. Films obtained on sapphire have a dense and transparent ceramic microstructure and photoluminescence properties similar to those of single crystals with same composition. The application of these films as laser media is envisaged.</jats:p
Preparation of Highly Textured Hydrogenation-Disproportionation-Desorption-Recombination Powders for Nd-Fe-B Sintered Magnets
No full textAs-cast Nd-Fe-B strips without an annealing treatment were treated by an appropriate hydrogenation-disproportionation-desorption-recombination (HDDR) process, and highly textured HDDR strip powders with uniform Nd-rich grain boundary layers can be obtained. The HDDR powders with a particle size of 50 mu m show a Br of 1.13 T and a (i) H-c of 10.5 kOe. The crystal texture in the HDDR powders may come from the memory for the own crystallographic orientation and the casting texture of Nd2Fe14B columnar grains in the as-cast strips. The highly textured HDDR powders with uniform Nd-rich grain boundary layers can be used to prepare the fine-grained sintered magnets by a conventional jet-milling technique and sintering process.SCI(E)EICPCI-S(ISTP)[email protected]
Association between Functional Polymorphisms of Foxp3 Gene and the Occurrence of Unexplained Recurrent Spontaneous Abortion in a Chinese Han Population
No full textUnexplained recurrent spontaneous abortion (URSA) is an alloimmune disease associated with the failure of fetal-maternal immunologic tolerance in which the regulatory T lymphocytes (Treg) play a pivotal role. It is well known that Forkhead box P3 (Foxp3) is a crucial regulatory factor for the development and function of Treg cells. It has also been established that deficiency of the Foxp3 gene suppresses the regulatory function of Treg cells. To determine if functional polymorphisms at the Foxp3 loci are associated with URSA in humans, we genotyped four common polymorphisms of Foxp3 gene in 146 unrelated URSA patients and 112 healthy women. The results showed that rs3761548A/C and rs2232365A/G polymorphisms were significantly associated with URSA. Additionally, we found that the allelic distribution of rs5902434 del/ATT in URSA group was slightly different from that in the control group. We conclude that functional polymorphisms of the Foxp3 gene may confer an important susceptibility to URSA in the Chinese Han population, probably by altering Foxp3 function and/or its expression
Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population.
No full textThe meiotic program initiation pathway genes (CYP26B1, NANOS1 and STRA8) have been proposed to play key roles in spermatogenesis.To elucidate the exact role of the genetic variants of the meiosis initiation genes in spermatogenesis, we genotyped the potential functional genetic variants of CYP26B1, NANOS1 and STRA8 genes, and evaluated their effects on spermatogenesis in our study population.In this study, all subjects were volunteers from the affiliated hospitals of Nanjing Medical University between March 2004 and July 2009 (NJMU Infertile Study). Total 719 idiopathic infertile cases were recruited and divided into three groups according to WHO semen parameters: 201 azoospermia patients (no sperm in the ejaculate even after centrifugation), 155 oligozoospermia patients (sperm counts 20×10(6)/ml). The control group consisted of 383 subjects with normal semen parameters, all of which had fathered at least one child without assisted reproductive technologies.Eight single nucleotide polymorphisms (SNPs) in CYP26B1, NANOS1 and STRA8 genes were determined by TaqMan allelic discrimination assay in 719 idiopathic infertile men and 383 healthy controls.The genetic variant rs10269148 of STRA8 gene showed higher risk of spermatogenic impairment in the groups of abnormospermia (including azoospermia subgroup and oligozoospermia subgroup) and azoospermia than the controls with odds ratios and 95% confidence intervals of 2.52 (1.29-4.94) and 2.92 (1.41-6.06), respectively (P = 0.006, 0.002 respective). Notably, larger sample size studies and in vivo or in vitro functional studies are needed to substantiate the biological roles of these variants.Our results provided epidemiological evidence supporting the involvement of genetic polymorphisms of the meiotic program initiation genes in modifying the risk of azoospermia and oligozoospermia in a Han-Chinese population
Cell wall components of gut commensal bacteria stimulate peritrophic matrix formation in malaria vector mosquitoes through activation of the IMD pathway
No full textCrystal Structure Manipulation of the Exchange Bias in an Antiferromagnetic Film
No full textExchange bias is one of the most extensively studied phenomena in magnetism, since it exerts a unidirectional anisotropy to a ferromagnet (FM) when coupled to an antiferromagnet (AFM) and the control of the exchange bias is therefore very important for technological applications, such as magnetic random access memory and giant magnetoresistance sensors. In this letter, we report the crystal structure manipulation of the exchange bias in epitaxial hcp Cr2O3 films. By epitaxially growing twined (1010) oriented Cr2O3 thin films, of which the c axis and spins of the Cr atoms lie in the film plane, we demonstrate that the exchange bias between Cr2O3 and an adjacent permalloy layer is tuned to in-plane from out-of-plane that has been observed in (0001) oriented Cr2O3 films. This is owing to the collinear exchange coupling between the spins of the Cr atoms and the adjacent FM layer. Such a highly anisotropic exchange bias phenomenon is not possible in polycrystalline films.National Basic Research Programs of China (973 Grants) [2013CB921903, 2015CB921104, 2014CB920902]; National Natural Science Foundation of China (NSFC Grant) [11574006]; 1000 Talents Program for Young Scientists of ChinaSCI(E)[email protected]; [email protected]
BASIC PERSPECTIVES OF VLADIMIR NABOKOV’S METAPHYSICS
No full textVladimir Vladimirovich Nabokov is a distinctive representative of Russian literature in the 20th century. His works are studied by many famous artists in many countries. The conciseness and beauty of his language are unique characteristics of Nabokov’s creation. His works show great philosophical depth, high moral values, and aesthetic accomplishments. His erudition has also attracted the attention of the world. This paper mainly expounds his metaphysical ideas: Nabokov’s metaphysics is mainly expressed in his great understanding of the world and his ability to understand and his longing for something grand and incomparable. His philosophical, ethical and moral ideas have incorporated the views of various literary schools, formalism, and structuralism at home and abroad. In addition, this article analyzes the relationship between philosophy, ethics, linguistics, reality and non-reality, reality and lies through the study of many works of the author; it clearly defines the distinction between “game” and “acting”; explained a series of problems of the author’s creation techniques; summed up the themes such as “time and permanence”, “memory and memories” in Nabokov’s works. These are all reflected frequently in Nabokov’s works. It is precisely because of this that his works have also been studied as metaphysical works for the public
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