5,103 research outputs found
Natural Variation of the Circadian Clock in Neurospora
No full textMost living organisms on earth experience daily and expected changes from the rotation of the earth. For an organism, the ability to predict and prepare for incoming stresses or resources is a very important skill for survival. This cellular process of measuring daily time of the day is collectively called the circadian clock. Because of its fundamental role in survival in nature, there is a great interest in studying the natural variation of the circadian clock. However, characterizing the genetic and molecular mechanisms underlying natural variation of circadian clocks remains a challenging task. In this chapter, we will summarize the progress in studying natural variation of the circadian clock in the successful eukaryotic model Neurospora, which led to discovering many design principles of the molecular mechanisms of the eukaryotic circadian clock. Despite the success of the system in revealing the molecular mechanisms of the circadian clock, Neurospora has not been utilized to extensively study natural variation. We will review the challenges that hindered the natural variation studies in Neurospora, and how they were overcome. We will also review the advantages of Neurospora for natural variation studies. Since Neurospora is the model fungal species for circadian study, it represents over 5 million species of fungi on earth. These fungi play important roles in ecosystems on earth, and as such Neurospora could serve as an important model for understanding the ecological role of natural variation in fungal circadian clocks.Advances in Genetics, Vol. 99
Corrigendum to “A generic multi-level framework for microscopic traffic simulation with automated vehicles in mixed traffic” [Transport. Res. Part C: Emerg. Technol. 110 (2020) 291–311] (Transportation Research Part C (2020) 110 (291–311), (S0968090X19304322), (10.1016/j.trc.2019.11.019))
No full textThe authors regret that a contributing author was missing from the list of authors. The complete list of authors should be: “S.C. Calvert, B. van Arem, & J. W. C. van Lint”. All are with Delft University of Technology, Department of Transport & Planning, The Netherlands updated as above. The authors would like to apologise for any inconvenience caused.Transport and Plannin
Towards the Holy Grail: combining system dynamics and discrete-event simulation in healthcare
No full textThe idea of combining discrete-event simulation and system dynamics has been a topic of debate in theoperations research community for over a decade. Many authors have considered the potential benefits ofsuch an approach from a methodological or practical standpoint. However, despite numerous examples ofmodels with both discrete and continuous parameters in the computer science and engineering literature,nobody in the OR field has yet succeeded in developing a genuinely hybrid approach which truly integratesthe philosophical approach and technical merits of both DES and SD in a single model. In this paperwe consider some of the reasons for this and describe two practical healthcare examples of combinedDES/SD models, which nevertheless fall short of the “holy grail” which has been so widely discussed inthe literature over the past decade
The Popularization of Zhu Shun-Shui’s Confucianism Thinking on Kaga-han
No full text本文旨在考察德川初期朱舜水（1600-1682）於加賀藩名君、第五代藩主前田綱紀（1643-1724）以及同為加賀藩學者之木下順庵（1621-1698）、奧村庸禮（1627-1687）、五十川剛伯（？-1699）等人推展儒教發展的過程中所作的貢獻，並檢討其與加賀藩「誠、敬、禮、學、行」等儒教體制形成之關係。前田綱紀的母親大姬（清泰院，1627-1656）是水戶藩首代藩主德川賴房（1603-1661）的女兒，基於這層關係，加賀藩的儒教發展深受水戶藩的影響。前田綱紀頻頻派遣奧村庸禮、五十川剛伯等學者至水戶藩受教於朱舜水，並與朱舜水有書信的往來。朱舜水去世後，前田綱紀隨即命五十川剛伯完成日本最初之朱舜水全集『明朱徵君集』（十卷，通稱加賀本）的編纂。至今加賀藩（現石川縣立美術館）及關西大學圖書館的貴重書庫，仍保存著許多前田綱紀與朱舜水相關之漢籍文獻史料。朱舜水主張「君是天子，忠於天子」，認為忠孝節義是皇統史觀的基本核心，而長年致力於「大義名分」的思想普及。前田綱紀曾聘請御用繪師狩野探幽（1602-1674）為南北朝時代的武將楠木正成（1294-1336）父子繪製「櫻井驛訣別圖」，並透過木下順庵敦請朱舜水撰寫「楠公父子決別圖贊」。爾後，這成為德川光?（1628-1701）編纂『大日本史』的重要精神所在，而楠木正成亦成為水戶學者崇敬的尊皇家。因此，本文之另一焦點，即在於探討朱舜水命名取字的思想主張所帶給加賀藩儒家政治思想的影響。This study intends to investigate the contributions made by Zhu Shun-Shui (1600-1682) in the early Edo Period during the process of the development of Confucianism promoted by the famous Kaga-han monarch Maeda Tunanori (1643-1724) who was the fifth Han-Su, as well as Kinoshita Jyunan (1621-1698) , Okumura Yasunori (1627-1687) , and Isogawa Kouhaku (?-1699) et al who were Kaga-han scholars, and to explore their relation with the formation of the Confucianism system “Honesty, Respect, Courtesy, Learning, and Practice” in Kaga-han. Maeda Tunanori’s mother, the imperial concubine (Seitaiin, 1627-1656) , was the daughter of Tokugawa Yorifusa who was the first Han-Su of Mito-han (1603-1661). Based on such relationship, the development of Confucianism in Kaga-han was deeply influenced by Mito-han. Maeda Tunanori frequently dispatched the scholars such as Okumura Yasunori, Isogawa Kouhaku, etc. to Mito-han to receive Zhu Shun-Shui’s teaching, and he also corresponded with Zhu Shun-Shui. After Zhu Shun-Shui passed away, Maeda Tunanori immediately ordered Isogawa Kouhaku to complete the first compilation of Zhu Shun-Shui Quan Ji “Collection of Ming Zhu Zheng Jun” in Japan (Ten scrolls, commonly called “Kaga Version”). Up to now, many Chinese classics as well as literatures and historical resources related to Maeda Tunanori and Zhu Shun-Shui are still preserved in the precious stacks in Kaga-han (now Ishikawa Prefectural Museum of Art) and Kansai University Library. Zhu Shun-Shui maintained that “The monarch is the Son of Heaven, and we should be loyal to the Son of Heaven”. He thought that “loyalty, piety, integrity, and righteousness” comprise the basic core of the imperial line’s historical scholarship, and he endeavored to popularize the thinking of “Righteous Cause” all the year round. Maeda Tunanori had once engaged his personal painter Tanyu Kano(1602-1674) for painting the “Picture of Parting at Sakurai Station” for the martial general Kasunoki Masashige (1294-1336) and his child in the Southern and Northern Dynasty. Also, through Kinoshita Jyunan, he earnestly invited Zhu Shun-Shui to write the “Comment for the Picture of General Kasunoki and his Child at Parting” that became the important essence of “the History of Great Japan” compiled by Tokugawa Mitsukuni later. Hence, Kasunoki Masashige also became the sonno practitioner adored by Mito scholars. Therefore, another focus in this article lies in exploring the influence on the Kaga-han Confucianism’s political thinking caused by Zhu Shun-Shui’s maintenance of the thinking of denomination and title selection
The Interpretation of Ying (媵) Marriage System by Jing-Shi (經師) of Han Dynasty and Their Asserts of Socio-political Background
No full text本論文主要在探討秦先秦媵婚制度的性質，及其落在漢代經學中的演變與發展，同時對於這種演變與發展的政治及社會背景作出理解及說明。我們認為漢代經師利用先秦曾經存在的媵婚制進行托古改制的理想，並將媵婚制構想成一套嚴密的體系，這套體系與神秘數字、星象、災異、養生、求子……等密切相關，同時也蘊含了經師希望帝王能節制後宮人數的苦心。The point of this article is the characters of ying marriage, and interpretations of Classics about Han dynasty, This article discusses through five aspects: 1. Definition of ying marriage, 2. The practice of ying marriage in pre-Ch’in period, 3. The arguments about ying marriage of Han Confucianists, 4. The background of interpretation about ying marriage by Jing-Shi, 5. Marriages and harems of the imperial household in Han dynasty. These analyses will help us to understand those situations of the ancient Chinese marriage system. I will explain that ying marriage’s theories in Han dynasty are based upon so many foundations, for example, shu (number of regularity), yin-yang(陰陽), astrology, anomalism, regimen, procreation, and control of numbers about the imperial harems
Hybrid simulation for health and social care: the way forward, or more trouble than it’s worth?
No full textFresh fruit and vegetables: a world of multiple interactions : the case of the Buenos Aires Central Wholesale Market (BACWM)
No full textThis research explores ethnographically the everyday social interactions between the ‘users’ of a particular marketplace, the Buenos Aires Central Wholesale Market (BACWM). The ‘users’ of this marketplace are the social actors who work there everyday, and who bring and buy fresh produce. These ´users´ are the ´makers´ of the BACWM since, through their everyday practices, interactions and interpretations and knowledge, they socially construct this hub of distribution
Cabardites xinyui Zhao & Wu & Han 2023, sp. nov.
No full textCabardites xinyui sp. nov. (Figs 1– 3, 10, 11, 17, 19, 21) urn:lsid:zoobank.org:act: 2BD8EEE8-5766-488E-B755-EFC102C56F27 Type-material. Holotype: ♂, China, Chongqing Municipality, Mt. Simian, 29.VII–2.VIII.2020, leg. H.L. Han & J. Wu, genit. prep. no. ztt-354-1. Paratypes: 8♂♂, 1♀, same data as holotype, genit. prep. no. ztt-351-1, ztt-352- 1, ztt-353-2, ztt-355-1, ztt-490-1, ztt-491-1, ztt-492-1, ztt-493-1, ztt-494-1; 2♂♂ 1♀, Chongqing Municipality, Mt. Simian, 1103m asl, 12–13. VII. 2018, leg. H.L. Han & C. Zhang, genit. prep. no. ztt-371-2, ztt-372-1, ztt-374-1; 1♂, Chongqing Municipality, Mt. Simian, 1–3. VIII. 2019, leg. T. T. Zhao & S.C. Deng, genit. prep. no. ztt-695-1, 1♂, Yunnan Province, Xishuangbanna, Mohan Town, 20. XI. 2020, leg. J. Wu et al., genit. prep. no. ztt-493-1.Published as part of Zhao, Ting-Ting, Wu, Jun & Han, Hui-Lin, 2023, Two new species and a new record of the genus Cabardites Volynkin & Černý (Lepidoptera, Erebidae, Arctiinae) from China, pp. 369-376 in Zootaxa 5339 (4) on page 370, DOI: 10.11646/zootaxa.5339.4.3, http://zenodo.org/record/830914
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