664 research outputs found
Datasets used for the spatial mode-based calibration (SMoC) paper
No full textDatasets for a journal paper "Spatial mode-based calibration (SMoC) of forecast precipitation fields from numerical weather prediction models".
In the SMoC paper, the performance of SMoC is evaluated by applying it to forecasts of substantive precipitation events over the Brisbane Drainage Basin in eastern Australia. This repository provides datasets of precipitation forecasts (3 years) and observations (33 years) at a grid spacing of 0.05° x 0.05° and on a daily basis for this case study: (1) Forecasts: "3-year forecast data.nc"; (2) Corresponding observations: "3-year observation data.nc"; (3) Long-term observations: "30-year observation data.nc". These three files are compressed into "Forecast and observation data.zip".
Author name: Pengcheng Zhao. Affiliation: Department of Infrastructure Engineering, Faculty of Engineering and Information Technology, The University of Melbourne. Email: [email protected]
Datasets-for-the-SMoC-paper
No full textDatasets for a journal paper "Spatial mode-based calibration (SMoC) of forecast precipitation fields from numerical weather prediction (NWP) models".
In the SMoC paper, the performance of SMoC is evaluated by applying it to NWP forecasts of substantive precipitation events over the Brisbane Drainage Basin in eastern Australia. This repository provides datasets of precipitation forecasts (ACCESS-G3, 3 years) and observations (AWAP, 33 years) at a grid spacing of 0.05° x 0.05° and on a daily basis for this case study: (1) NWP forecasts: "ACCESS-G3_3-year_forecasts.nc"; (2) Corresponding observations: "AWAP_3-year_observations.nc"; (3) Long-term observations: "AWAP_30-year_observations.nc".
Considering that these three files are too large to be uploaded directly, they are compressed into "ACCESS-G3 and AWAP datasets.zip".
Author name: Pengcheng Zhao. Affiliation: Department of Infrastructure Engineering, Faculty of Engineering and Information Technology, The University of Melbourne. Email: [email protected]
Über die Möglichkeit einer kontinuierlichen und zügigen Fortsetzung des chinesischen Modernisierungsprozesses
No full textDer Autor dieses Vortrags, Prof. Dr. Li Pengcheng, ist Vizedirektor des Forschungszentrums für Sozialentwicklung der Chinesischen Akademie für Sozialwissenschaften. Im September und Oktober 1997 war er zum zweiten Mal, nach 1994, als Gastwissenschaftler der Abteilung Sozialstruktur und Sozialberichterstattung am Wissenschaftszentrum Berlin für Sozialforschung. Der Vortrag schließt an den Bericht „Der chinesische Modernisierungsprozeß in den achtziger Jahren an, der als WZB-Paper P 95-001 veröffentlicht worden ist. Wir veröffentlichen den Vortrag als Zeitdokument der derzeitigen innerchinesischen Diskussion. Die Anschrift des Verfassers lautet: Prof. Dr. Li Pengcheng Institute of Philosophy Chinese Academy of Social Sciences 5, Jianguomen Nei Dajie 100732 Beijing China Für die Übersetzung aus dem Chinesischen danken wir Frau Gisela Reinhold.The author of this lecture, Professor Li Pengcheng, is Vice-director of the Research Center for Social Development at the Chinese Academy of Social Sciences. In September and October 1997 he was for the second time after 1994 a Visiting Scholar at the WZB, Research Unit Social Structure and Social Reporting. The lecture is a follow-up of the author's report „The Chinese modernization in the 1980 which was published as WZB-paper P 95-001. Again we publish this lecture as an actual document of the present Chinese modernization debate. For the translation from Chinese we are grateful to Ms. Gisela Reinhold
On the discussion about Zhi Dao between Confucius and Lao-tzu in Zhuangzi
No full textBased on the materials about Confucius meeting with Lao-tzu in Zhuangzi, this paper studies about their discussion about Zhi Dao (the regulation of the courses). The strategy of Confucius on Zhi Dao is expounded, and the criticism from Lao-tzu on that is analyzed, as well as Lao-tzu's further proposition on Zhi Dao.CPCI-SSH(ISSHP)541-5468
GRASPTrack: geometry-reasoned association via segmentation and projection for multi-object tracking
No full textMulti-object tracking (MOT) in monocular videos is fundamentally challenged by occlusions and depth ambiguity, issues that conventional tracking-by-detection (TBD) methods struggle to resolve owing to a lack of geometric awareness. To address these limitations, we introduce GRASPTrack, a novel depth-aware MOT framework that integrates monocular depth estimation and instance segmentation into a standard TBD pipeline to generate high-fidelity 3D point clouds from 2D detections, thereby enabling explicit 3D geometric reasoning. These 3D point clouds are then voxelized to enable a precise and robust Voxel-Based 3D Intersection-over-Union (IoU) for spatial association. To further enhance tracking robustness, our approach incorporates Depth-aware Adaptive Noise Compensation, which dynamically adjusts the Kalman filter process noise based on occlusion severity for more reliable state estimation. Additionally, we propose a Depth-enhanced Observation-Centric Momentum, which extends the motion direction consistency from the image plane into 3D space to improve motion-based association cues, particularly for objects with complex trajectories. Extensive experiments on the MOT17, MOT20, and DanceTrack benchmarks demonstrate that our method achieves competitive performance, significantly improving tracking robustness in complex scenes with frequent occlusions and intricate motion patterns
Streptococcus suis serotype 2 strains isolated in Argentina (South America) are different from those recovered in North America and present a higher risk for humans
No full textFil: Callejo, Raquel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Zheng, Han. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control, Changping, Beijing, PR; China.Fil: Du, Pengcheng. Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing Key Laboratory of Emerging Infectious Diseases, Beijing, PR; China.Fil: Prieto, Mónica A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Xu, Jianguo. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control, Changping, Beijing, PR; China.Fil: Zielinski, Gustavo. Instituto Nacional de Tecnologia Agropecuaria (INTA), Marcos Juárez, Córdoba; Argentina.Fil: Auger, Jean-Philippe. Swine and Poultry Infectious Disease Center, (CRIPA), Faculty of Veterinary Medicine, University of Montreal, St-Hyacinthe, Quebec; Canada.Fil: Gottschalk, Marcelo. Swine and Poultry Infectious Disease Center, (CRIPA), Faculty of Veterinary Medicine, University of Montreal, St-Hyacinthe, Quebec; Canada.Streptococcus suis serotype 2 is an important swine pathogen and emerging zoonotic agent causing meningitis and septicemia/septic shock. Strains are usually virulent (Eurasia) or of intermediate/low virulence (North America). Very few data regarding human and swine isolates from South America are available
Single-cell transcriptomic profiling of goat milk somatic cells highlights immune heterogeneity and epithelial cell-related networks
No full textThe global goat milk market has expanded rapidly, driven by its reputed hypoallergenic properties and associated health benefits. Here we present the first single-cell RNA sequencing (scRNA-seq) atlas of somatic cells in mid-lactation Saanen goat milk, revealing cellular heterogeneity and immune-regulatory mechanisms. Analysis of 7276 high-quality cells from five biological replicates revealed seven populations: myofibroblasts, dendritic cells (DCs), epithelial cells (EPCs), monocytes, bone marrow-derived progenitor cells, neutrophils, and T cells. The proportion of EPCs varied markedly between individuals (23.18 %–94.09 %, p = 0.0295) and was positively correlated with somatic cell count (R = 0.6087, based on five biological replicates), suggesting a moderate association. Pseudotime analysis revealed two differentiation trajectories: high-epithelial samples (HPG; >80 % EPCs) were dominated by immune-cell- dominated, whereas low-epithelial samples (LPG; <60 % EPCs) primarily exhibited epithelial differentiation. Cell-cell communication analyses showed distinct signaling: SELL/CXCL-mediated immune pathways were activated in HPG, while TGF-β/SPP1 signaling—linked to cell migration and immune suppression—was upregulated in LPG. A total of 214 differentially expressed genes (DEGs) were identified. Pro-inflammatory factors, such as SAA and PAEP, were enriched in HPG, whereas anti-inflammatory markers, including SERPIN B3 and C3, were elevated in LPG. Notably, casein genes (CSN1S2, CSN2, CSN3) were markedly upregulated in immune cells of HPG (T cells, monocytes and DCs). In conclusion, this work unveils a key cellular biomarker for milk quality, which is expected to guide the dairy industry towards producing safer and hypoallergenic goat milk products
Notch Signaling: Mechanistic And Functional Studies In Intestinal Stem Cells And Colorectal Cancer Cells
No full text: The study of stem cell regulation in intestinal and colonic tissues is an area of significant focus within the scientific community, providing mechanistic insight into biological process and offering translational clinical potential. In this thesis we address the contribution of NOTCH signaling in maintaining the stem cell niche by modulating the mode of stem cell division and receptor-ligand interactions for cell-cell communication. Furthermore, we examine NOTCHmediated spatiotemporal recovery of the intestinal stem cell (ISC) niche following single cell ablation. Finally, we demonstrate that elevated NOTCH signaling exists under conditions of physiological stress and in colon cancer initiating cells (CCICs), promoting tumorigenic potential of the intestinal epithelium. Overall, our research highlights the underlying complexities of NOTCH signaling as an essential pathway to maintain intestinal homeostasis and may inspire development of novel CRC therapeutic strategies. Research efforts and findings during my graduate study have been consolidated into the following peer-reviewed publications, of which the four first co-author manuscripts are described in detail in this dissertation. 1. Srinivasan, Tara; Walters, Jewell; Bu, Pengcheng; Than, Elaine B.; Tung, Kuei-Ling; Chen, Kai-Yuan; Panarelli, Nicole; Milsom, Jeff; Augenlicht, Leonard; Lipkin, Steven M; Shen, Xiling. "NOTCH Signaling Regulates Asymmetric Division of Fast- and Slow-Cycling Colon Cancer Initiating Cells." Cancer Research, 2016. (in press) 2. Srinivasan, Tara; Than, Elaine B.; Bu, Pengcheng; Tung, Kuei-Ling; Chen, Kai-Yuan; Augenlicht, Leonard; Lipkin, Steven M.; Shen, Xiling. "NOTCH Signaling Regulates Fast- and Slow-Cycling Intestinal Stem Cells." Scientific Reports, 2016. (in press) 3. Chen, Kai-Yuan*; Srinivasan, Tara*; Choi, Jiahn*; Bu, Pengcheng; Tung, Kuei-Ling; Nishimura, Nozomi; Shen, Xiling. "Dynamic regulation of intestinal stem cell niche recovery in real-time." Cell Systems, 2015. (in review) 4. Murthy, Preetish KL*; Srinivasan, Tara*; Bochter, Skye; Bu, Pengcheng; Cole, Susan; Shen, Xiling. "FRINGE-dependent modification of NOTCH Ligands in Intestinal Stem Cells." 2016. (in preparation) 5. Rothschild, Daniel; Srinivasan, Tara; Aponte-Santiago, Linette; Shen, Xiling; Irving, Allen. "The Ex Vivo Culture and Pattern Recognition Receptor Stimulation of Mouse Intestinal Organoids." JoVE, 2015. (in press) 6. Bu, Pengcheng*; Wang, Lihua*; Chen, Kai-Yuan; Srinivasan, Tara; Lakshminarasimha, Preetish; Tung, Kuei-Ling; Varanko, Anastasia; Ai, Yiwei; Lipkin, Steven; Shen, Xiling. "miR34a and Numb synergize for asymmetric cell fate determination." Cell Stem Cell, 2016 Feb 4;18(2):189-202. 7. Crespo, Miguel; Tsai, Su-Yi; Srinivasan, Tara; Pipalia, Nina; Maxfield, Nina; Lipkin, Steven M; Evans, Todd; Chen, Shuibing. "Colonic Organoids Derived from Human Pluripotent Stem Cells for Modeling Colorectal Cancer and Drug Testing." Nature Medicine, 2015. (in review) 8. Wang, Lihua*; Bu, Pengcheng*; Ai, Yiwel; Srinivasan, Tara; Lipkin, Steven M; Shen, Xiling. "A Long Non-Coding RNA Targets MicroRNA miR-34a to Regulate Colon Cancer Stem Cell Asymmetric Division." eLife, 2016. (in press
Gong Pengcheng’s critical study of the “lyric tradition” theory
No full text“Lyric tradition” was put forward by Chen Shixiang, a scholar in the United States, in a speech in the 1970s.It became a view of the characteristics of Chinese literature, and was developed and widely accepted in the later literary criticism,becoming one of the most productive views of foreign Sinology in the last century. But in recent years in the academic circle of its theory system,there are some dissenting voices on the system, among which the most critical criticism is written by Taiwan scholar Gong Pengcheng The Nonexistent Tradition —— On Chen Shixiang’s Lyrical Tradition. The author tries to criticize the lyric tradition from Gong Pengcheng,starting with the original document, to have an overview of Gong’s lyric tradition and explore why the “lyric tradition” is still quite influential despite of the fierce suspicion; Whether there is a stronger narrative tradition beyond lyricism
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