1,722,907 research outputs found
Overexpression of and RNA interference with the CCAAT enhancer binding protein on long-term facilitation of Aplysia sensory to motor synapses
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UCHL5 control B-catenin destruction complex function through Axin1 regulation
No full textWnt/β-catenin signaling is crucially involved in many biological processes, from embryogenesis to cancer development. Hence, the complete understanding of its molecular mechanism has been the biggest challenge in the Wnt research field. Here, we identified ubiquitin C-terminal hydrolase like 5 (UCHL5), a deubiquitinating enzyme, as a novel negative regulator of Wnt signaling, upstream of β-catenin. The study further revealed that UCHL5 plays an important role in the β-catenin destruction complex, as it physically interacts with multiple domains of Axin1 protein. Our functional analyses also elucidated that UCHL5 is required for both the stabilization and the polymerization of Axin1 proteins. Interestingly, although these events are governed by deubiquitination in the DIX domain of Axin1 protein, they do not require the deubiquitinating activity of UCHL5. The study proposes a novel molecular mechanism of UCHL5 potentiating the functional activity of Axin1, a scaffolder of the β-catenin destruction complex.11Ysciescopu
Identification and characterization of Aplysia LAPS18-like protein (ApLLP): Enhanced the induction of long-term synaptic facilitation
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Analysis of the contributions of PKA and PKC to syanptic facilitation in non-depressed and depressed synapses by ectopic expression of Aplysia octopam
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