15 research outputs found
The association between mastication and mild cognitive impairment in Korean adults
No full textCurrently, a few of studies revealed that there is an association between mastication and cognitive impairment. There is no study of Korean adult representative samples in relation to mastication and cognitive decline. This study was to investigate the relationship between mastication and mild cognitive impairment in Korean adults. A population-based cross-sectional study was conducted in which a total of 7029 subjects (2987 men and 4042 women) over 45 years old were surveyed from the Korea Longitudinal Study on Aging (KLoSA), Round 5th survey. Logistic regression analysis was performed for the study data controlling for confounding factors such as age, gender, education, income, smoking, drinking, exercise, wearing denture, and the number of chronic diseases. Decreased chewing function is associated with mild cognitive impairment (odds ratio [OR] = 3.24, 95% confidence interval [CI] = 2.67-3.93) after controlling for confounding variables. In the participants who did not wear dentures, the reduction of chewing function was strongly correlated with mild cognitive impairment (OR = 3.97, 95% CI = 3.11-5.08). Mastication was associated with mild cognitive impairment. To prevent cognitive decline, health specialists should pay more attention to the decline of the mastication in people without dentures.Y
Development of Overseas Science & Technology Information Resources and Management of NDSL
No full textfunder : 과학기술부agency : 과학기술부agency : Ministry of Science & Technology본 연구사업은 해외 과학기술 정보의 체계적 수집 및 적시적 배포를 통해 연구개발 생산성 향상을 지원하는 국가R&D 정보센터를 구현코자 하는 사업으로 해외 핵심 정보자원 개발 및 아카이빙, 정보 수요자 중심 고품질 콘텐트 개발, 글로벌 정보협력 및 연계체제 구축, 정보서비스 개발 및 운영 등의 측면에서 수행되었으며 주요 성과는 다음과 같다.
■해외 핵심 정보자원 개발 및 아카이빙
- 과 을 적용하고 NDSL 협력기관 보유 자원 분석을 통한 확충 및 연계를 추진하여 정보접근성 75% 이상 달성
- KISTI를 중심으로 한 해외 회색문헌 개발 및 유통모형 구축
■정보 수요자 중심 고품질 콘텐트 개발
- 韓英中日학술정보 메타 콘텐트 3,374,646건 구축 및 DPC 기준 DB 품질평가 97.3점
- 국가 가용자원 맵 구축 및 한중일 과학기술정보 공유 모형 개발
■글로벌 정보협력 및 연계체제 구축
- 정보유통 협의체의 발전적 통합 및 전자정보 공동구매를 통해 해외 학술정보의 국가적 이용기반 확충 : 73개 해외 출판사 전자저널 9,840종 제공, 국내 산학연 345개 기관 참가
- 원문복사서비스 협력 채널 단일화 및 확대, 정보관리연구 발간 및 글로벌 CDRS 수행
■정보서비스 개발 및 운영
- NDSL 시스템을 개방형 전산환경으로 마이그레이션 및 기능 고도화 수행
- KISTI-DDS 시스템을 NDSL DDS 기능을 수용할 수 있는 웹기반 시스템으로 재개발
- 학술정보 디지털 아카이브 테스트베드 구축(1) To Develop Overseas Core Information Resources and Archiving
To increase availability of 15,000 out of 20,000 core global scientific journals on the basis of national demand forecasting for S&T information and the analysis of user group study, and archive some of them in order to develop into a global knowledge information center by stages
- To collect 15,000 foreign core scientific journals.
- To collect more than 2,000 conference proceedings, and more than 15,000 technical reports
(2) To Develop High-quality Contents and Provide Relevant Service centered on Information Users
To develop meta DB for overseas scientific technology in English, Japanese, and Chinese and help locate and improve accessibility to information held nationally by the national union catalog of science and technology journals based on international standards. To construct basic infrastructures to activate national R&D, with information at 95% quality level.
- To construct user-centered high-quality meta DB: 3 million a year
(3) To Construct Global Information Sharing and Cooperation Networking Systems
To complete the taking a role of umbrella in information distribution system, intensify the cooperative with academia, industries and research institutes for buying overseas academic research information, and build basis for a global knowledge information sharing system.
- To raise the efficiency and enlarge management of KESLI
- To enlarge Document Delivery Services and cooperation institutes : to merge NDSL and National Research Information Association participants
- To manage Collaborative Digital Reference Service(CDRS) domestic consortium and provide service using Global Network for users
(4) To Develop and Manage Information Services
To support the comprehensive accessibility to information for R&D researchers by constructing and managing the portal service for academic information, and develop user friendly services by improving the services based on researching user group study and monitering user services.
- To migrate NDSL into KISTI infrastructure and intensify functions of NDSL
- To redevelop KISTI-DDS system and improve KIRIS system
- To construct archiving testbed for ST electronic informatio
Overseas Information Resources Development
No full textfunder : 과학기술부agency : 과학기술부agency : Ministry of Science & Technology본 연구사업은 과학기술정보자원의 효율적인 유통체제 구축과 호혜적인 공유협력기반 형성을 목표로 하고 있다. 이를 위해 본 연구사업은 해외핵심 과학기술정보 개발 및 부존자원화, 국제표준의 고품질 정보콘텐트 개발, 글로벌 지식정보 유통기반 조성 측면에서 수행되었다. 2004년 한 해동안 수행된 주요 연구 성과는 다음과 같다.
해외 핵심과학기술정보개발 및 부존자원화 : KISTI 가 2003년 수립한 정보자원개발 5대원칙을 적용하여 핵심자원개발의 범위 및 방법을 정예화 하였다. 해외정보자원 중 해외핵심학술지 13,171종, 학술회의자료2,123 건, 기술보고서 15,887 건을수집하였다. Web of Science 등메타DB의 국가 액세스컨소시엄 운영을 통하여 National License Officer 의 역할을 수행함으로써 자원개발의 가용성과 경제성을 제고하고자 하였다.
국제표준의 고품질 정보콘텐트 개발 : KISTI 콘텐트 품질향상을 위하여 Working Group 을 운영하고 그 결과 산출된 Action Plan 에 의거하여 메타정보고품질화를 추진하였다. 국내보유 핵심정보 자원을활용하여 국가과학기술전문정보DB459,449 건, 국내외 산업재산권DB 1,579,497 건을구축 하였다.
글로벌 지식정보 유통기반 조성 : 국내 최초로 OCLC Governing Member 에 가입하고, 국제협력디지털 참고정보서비스 Question 포인트 한글시스템을 구현하여 고품질의 과학기술참고서비스를 실시하였다. 국내 대학도서관 및 연구소 165개 기관이 참여하는 국가연구정보협의회의 협력사업으로, 회원기관에 KISTI Express 및 e-DDS 플랫폼을 보급하여 저렴한 원문제공체제를구축하였다.
또한 정보관리시스템(KIRIS) 를 개발하여 Z39.50 프로토콜 및 웹서비스 기능 뿐만 아니라 XML 레코드의 반입/반출 기능을 구현하였다.
본 연구사업의 성과측면에서, KISTI 정보자원은 정보형태, 주제 및 이용 면에서 최근 국내외 과학기술정보 생산 및 유통, 이용자 정보환경변화, 국가발전의 전략적 방향 등을 반영하여 국가연구 개발 경쟁력 향상에 기여할 것이다. 또한 해외 과학기술정보의 데이터베이스 통합제작 및 유통을 통해 국내 산학연 연구자의 효율적인 정보접근권을 보장하고 정보활용을 촉진하였다. 학술지 종합목록을 통해 국내 보유중인 정보자원의 소재파악이 용이해져 정보자료 중복구입을 예방하고 정보자원의 적시적 공동 활용에 기여하며, 국내 최저가 원문제공체제를 개선하여 선진국 수준의 정보공유 환경을 조성하는데 기여하였다.The effective integration and dissemination of science and technology knowledge information resources is able to accelerate creation of information and bring high value- added information by improving on science and technology R&D competitiveness. Overseas Information Resources Development is necessary to support national science and technology innovation and distribute foreign cutting-edge science and technology information to domestic users
Environmental Security and its Implications for China’s Foreign Relations
No full textChina’s emerging standing in the world demands a major rethinking of its diplomatic strategies. Given its population size, geographical scale, economic power and military presence, China is poised to play a larger political role in the twenty-first century, and is thus perceived by the international community to have greater capacities, capabilities and responsibilities. At the same time, environmental stresses caused by China’s energy and resources demands have become increasingly evident in recent years, urging China to cultivate delicate diplomatic relations with its neighbors and strategic partners. Tensions have been seen in areas such as transboundary air pollution, cross-border water resources management and resources exploitation, and more recently in global issues such as climate change. As the Chinese leadership begins to embrace the identity of a responsible developing country, it is becoming apparent that while unabated resources demands and environmental deterioration may pose a great threat to environmental security, a shared sense of urgency could foster enhanced cooperation. For China to move beyond existing and probable diplomatic tensions, a greater attention to domestic and regional environmental security will no doubt be necessary. This article explores such interrelations among domestic, regional and global environmental securities and China’s diplomacy, and suggests possible means by which China could contribute to strengthening global environmental security.Acid Rain, Climate Change, Energy, Environmental Security, Transboundary Air Pollution, Water Resource Management, Asia
Design and development of a lipopolymeric microparticular system for the administration od a synthetic peptide of hydrophilic nature
No full textilustraciones, fotografías, graficasEn los últimos años se ha despertado un gran interés por los sistemas para la entrega de fármacos (SEF) mediante liberación controlada, debido a que permiten superar ciertas limitaciones de algunos ingredientes farmacéuticos activos (IFAs). Entre estos IFAs, se destacan los péptidos que, a pesar de ser degradados rápidamente, son moléculas
esenciales en la vida debido a la posibilidad que tienen de cumplir múltiples funciones en el organismo, lo que ha permitido que sean considerados como IFA de elección para tratar numerosas enfermedades.
Se ha reportado que los SEF particulados son capaces de proteger a moléculas lábiles como los péptidos de agentes externos como las enzimas, haciendo que se prolongue su tiempo de vida media y por tanto mejorando su actividad. Teniendo en cuenta esto se han diseñado diferentes SEF, entre ellos los liposomas, las partículas poliméricas y las
partículas sólidas lipídicas, siendo estos sistemas los que han mostrado de manera general los mejores resultados como transportadores de IFAs. Producto de estas investigaciones, se ha mostrado un gran interés en desarrollar un SEF que permita reunir las ventajas de las partículas poliméricas y las partículas sólidas lipídicas, planteándose
de esta forma el diseño y desarrollo de los sistemas híbridos lipopoliméricos.
Con el propósito de contribuir en el campo de la investigación de SEF, en el marco de este trabajo se planteó el desarrollo una metodología para la obtención de tres sistemas particulados: micropartículas poliméricas, partículas sólidas lipídicas y micropartículas lipopoliméricas, empleando como material polimérico PLGA 50:50 (Viscosidad inherente: 0,8dL/g) y como material lipídico una mezcla de mono, di y triglicéridos C12-C18. Todos los
sistemas se obtuvieron vacíos y cargados con un péptido sintético modelo de naturaleza hidrofílica, mediante la metodología de doble emulsión – evaporación del solvente Todos los sistemas fueron caracterizados en cuanto a morfología, tamaño, potencial Z, eficiencia de encapsulación y perfil de liberación del péptido. Como resultado, se logró obtener partículas en su mayoría esféricas de tamaño micrométrico para los sistemas poliméricos (3,08-5,60 µm) y lipopoliméricos (3,22-3,93 µm), de tamaño nanométrico para el sistema sólido lipídico (135,8-162,9 nm) y con un potencial Z entre -18,5mV y -24,5mV para las micropartículas poliméricas, -15,5mV y -29,9mV para las partículas sólidas lipídicas, -20,0mV y -26,1mV para las micropartículas lipopoliméricas. En cuanto a la eficiencia de encapsulación se determinó que el mejor sistema fue el de las micropartículas poliméricas con una E.E. promedio del 57,42% seguido de las micropartículas lipopoliméricas cuya E.E. promedio fue de 43,15% y las partículas sólidas lipídicas con una E.E. promedio del 40,40%. En referencia al perfil de liberación, se observó que las micropartículas lipopoliméricas tienden a mostrar un comportamiento intermedio entre los observados en las micropartículas poliméricas y en las partículas lipídicas. En conclusión, en este trabajo se desarrolló una metodología para la obtención y caracterización de un sistema micropartícular lipopolimérico que permite la encapsulación
de un péptido sintético modelo de naturaleza hidrofílica con características tanto de micropartículas poliméricas (Tamaño y morfología) como de partículas sólidas lipídicas (E.E. y perfil de liberación). (texto tomado de la fuente)In recent years, controlled release drug delivery systems (DDS) have had great interest due they make possible to overcome certain limitations of some active pharmaceutical ingredients (APIs), between these APIs stand out peptides that despite of fast degradation, are essential molecules in life due to the possibility to accomplish multiple functions in the body, this has allowed to be considerate as choice API to treat numerous diseases. Particulate DDS have been shown to be able to protect labile molecules such as peptides from external agents such as enzymes, prolonging their half-life and therefore improving their activity. Bearing this in mind, different DDS have been designed, including liposomes, polymeric particles, and solid lipid particles, these being the ones that in general have shown better results as APIs carriers. As product of these research a great interest has been shown in developing a DDS that allows to have advantages of polymeric particles and solid lipid particles, proposing in this way the design and development of hybrid lipopolymeric systems.
With the purpose of contribute to research field of DDS, within the framework of this work, the development of a methodology for the obtention of three particulate systems: Polymeric microparticles, solid lipid particles and lipopolymeric particles was proposed, using as polymeric material PLGA 50:50 (Inherent Viscosity 0,8 dL/g) and as lipidic material a mixture of mono, di and triglycerides C12-C18. All systems were obtained empty and loaded with a model synthetic peptide of hydrophilic nature using a methodology of double emulsion – solvent evaporation.
All systems obtained were characterized in terms of morphology, size, Z potential, encapsulation efficiency and release profile. As result, was achieved particles mostly spherical, of micrometrical size for polymeric systems (3,08-5,60 µm) and lipopolymeric (3,22-3,93 µm), nanometrical size for the solid lipid system (135,8-162,9 nm), with a Z potential between -18,5mV -and -24,5mV for the polymeric particles, -15,5mV and -29,9mV for the solid lipid particles and -20,0mV and -26,1mV for the lipopolymeric particles. Regarding encapsulation efficiency, it was observed that lipopolymeric particles tend to show an intermediate behavior between the behavior observed in polymeric particles and in lipid particles.
In conclusion, in this work a method was developed to obtain and characterize a lipopolymeric microparticle system that allows the encapsulation of a model synthetic peptide of a hydrophilic nature with characteristics of both polymeric particles (size and morphology) and solid lipid particles (E.E. and release profile).MaestríaMagíster en Ciencias FarmacéuticasTecnología Farmacéutica: Sistemas micro y nano particulare
Construction of the National Science and Technology u-Library System
No full textfunder : 과학기술부agency : 과학기술부agency : Ministry of Science & Technology본 연구의 목적은 지식정보의 효율적 창출?활용?확산이 국가기술혁신의 핵심요소로 등장함에 따라 지식기반 사회 성장과 혁신의 기반자원으로서 국내외 연구개발 정보의 체계적 수집 및 적시적 배포를 통해 국가 연구개발 생산성 향상을 지원하는 과학기술 u-Library 체제를 구축하고자 한다.
o 정보유통 기반 고도화 및 지식확산체제 구축
- 정보유통 기반연구, 프로세스 개선 및 신규 콘텐트 기획
- 산학연 협력 및 지식확산 체제 구축
- 글로벌 정보공유를 위한 협력네트워크 운영
o 국가 고유정보자원의 망라적 개발 및 공유체제 구축
- 국가 고유 정보자원의 망라적 개발 및 아카이빙
- 국가 학술정보 콘텐트 개발
- 국내 학협회정보화 지원사업 확대 및 전자원문 유통체제 구축
- 국가 고유정보 해외유통 프레임워크 및 시범서비스 체계 구축
o 해외 핵심정보자원 개발 및 공유체제 구축
- 해외 핵심정보자원의 전략적, 단계적 개발 및 아카이빙
- 영문일문중문 학술정보 메타데이터 개발
- 전자정보 도입의 경제성 제고를 위한 컨소시엄 추진 및 운영
- 국내 보유자원 공동활용을 위한 정보기관간 협력체제 구축
o 사실정보 데이터 수집, DB 개발 및 공동활용 체제 구축
- 사실정보, 생명정보 데이터 수집, DB 개발 및 공동활용 체제 구축
o 정보유통 시스템 개발 및 지원체제 구축
- 국내외 정보자원의 효율적인 관리 및 DB구축 기술 지원
- 글로벌서비스를 위한 전자적 정보유통 시스템 개발 및 운영 Enhancement of information distribution infra and construction of knowledge diffusion system
- To plan and conduct basic research for enhancement of national STI distribution system
- To re-establish the road map for KISTI information resource development and policies
- Industrial/Academia/Research cooperation and knowledge dissemination(publishing Journal of Information Management, holding seminars, and conducting joint researches)
- To manage cooperation networks for domestic and overseas information sharing(including DDS, CDRS)
- To construct user monitoring systems and establish policy for promotion and marketing
- To intensify the analysis functions for National Available Resource Map
- To study on CJK information sharing system
Development and connection for domestic information resources
- To develop comprehensively and archive national information resources(2,011 titles, 100\percnt)
- To develop national information content Bibliography and full-text journals DB of academic societies and associations : 128,000 records from 526 institutes
Collection of deposit technical reports and production of DB : 2,000 titles
- To expand and support academic societies/associations information and construct distribution system for full-text electronic journals
To support and sign MOU with academic societies/associations : new 30 academic societies and 20 associations(total of 526)
To supply and manage KISTI-ACOMS : new 30 societies
(total of 261)
To construct and manage homepages for academic societies : new 30 homepages(total of 172)
- To maintain and upgrade the functions on information systems for academic societies and associations
- To construct domestic Scholarly information DB in English and distribute Korean STI to the world
Development and connection for overseas core information resources
- To achieve 80\percnt of information accessibility by collecting and connecting overseas core information resources
16,000 titles of Journals, 2,200 items of conference proceedings,16,000 items of technical reports
- To construct collection and distribution system for high quality free of charge information produced by overseas important cooperation institutes
- To develop English, Japanese and Chinese metadata
3 million records of English records, 280,000 domestic English/Japanese/Chinese records, KEST CD
- To expand management of consortium(350 participating institutes)
Supply of KESLI content : 11,000 titles by 90 publishers, 280 DDS cooperation institutes
- To strengthen efficiency of consortium management and cooperation networking
To enlarge the condition consideration committee, and management of Association for National STI Distribution
- To collect and archive 15 full-text electronic journals
- To develop electronic information license model and analysis ofefficiency
Development of fact information and construction of public utilization system
- To construct, manage and connect chemical compound DB
- To enlarge and construct other fact information(FactGate) and Statistic material DB
- To construct, manage and connect biological diversity information
Development of information distribution system and construction of supporting system
- To improve and manage the library management system for holding materials(KIRIS)
- To construct and support academic papers and patent DB and expand the functions
- To develop consortium for electronic journals and license management system
- To manage and construct yesKISTI and NDSL DB
- To construct digital archiving and linking system
- To develop document delivery system and custom-made information servic
Japan's Recalibration of Risk: The Framing of North Korea
No full textThis dissertation examines the role of risk in international relations – including its interactive relationship with domestic civil society – from a case study perspective. The research aims to disentangle complex processes by which Japan has framed and recalibrated risks in response to North Korea, and how those risks have been mediated between the state, market and society . Therein, while acknowledging the relevance of established International Relations (IR) theories, it highlights their limitations in terms of an inability to comprehensively assign agency for processes of inter-state-society change, and state governance. The study is, therefore, necessary in order to better understand how such processes are socio-politically contingent in relation to risk, and the implications for issues of national security and identity. This includes stimulating further research into how risk is instrumental in justifying political agendas, facilitating policy reforms, and as a key agent in continuing discourses. In order to gain an empirical understanding of how agency operates within processes of risk recalibration across domestic and international spheres, actors such as policy makers, mass media, and civil society stakeholders have been identified as the primary targets of analysis. A combination of Constructivist-derived theories and conceptions from literature on risk are employed as the theoretical framework within which to analyse empirical data – primarily pertaining to Japan's responses to post-Cold War North Korean missile and nuclear tests – assimilated from a combination of qualitative and quantitative sources relating to the areas specified above. The conclusion drawn from the case studies examined is that the recalibration of risk by Japan in response to North Korea highlights how risk governance at the state level – via processes of mediation between the state, market and domestic society – causes reverberations at bilateral, regional and, ultimately, global levels. Specifically, in the case of Japan, there has been a significant impact in terms of changes to societal norms, national identity and state-level policies; facilitated through the aggregated processes of risk recalibration.EThOS - Electronic Theses Online ServiceGBUnited Kingdo
Dissociation Between the Growing Opioid Demands and Drug Policy Directions Among the U.S. Older Adults with Degenerative Joint Diseases
No full textWe aim to examine temporal trends of orthopedic operations and opioid-related hospital stays among seniors in the nation and states of Oregon and Washington where marijuana legalization was accepted earlier than any others. As aging society advances in the United States (U.S.), orthopedic operations and opioid-related hospital stays among seniors increase in the nation. A serial cross-sectional cohort study using the healthcare cost and utilization project fast stats from 2006 through 2015 measured annual rate per 100,000 populations of orthopedic operations by age groups (45–64 vs 65 and older) as well as annual rate per 100,000 populations of opioid-related hospital stays among 65 and older in the nation, Oregon and Washington states from 2008 through 2017. Orthopedic operations (knee arthroplasty, total or partial hip replacement, spinal fusion or laminectomy) and opioid-related hospital stays were measured. The compound annual growth rate (CAGR) was used to quantify temporal trends of orthopedic operations by age groups as well as opioid-related hospital stays and was tested by Rao–Scott correction of χ2 for categorical variables. The CAGR (4.06%) of orthopedic operations among age 65 and older increased (P...) (See full abstract in article
Structural and functional investigation of the cytoplasmic domain of the Fas death receptor
No full textActivation of the transmembrane death receptor Fas (CD95/APO-1) by a membrane bound ligand (FasL/CD95L) activates the extrinsic pathway of apoptosis. Intracellular Fas death domains (DDs) are induced to oligomerise enabling binding to the adaptor protein FADD, thereby leading to the recruitment of procaspase 8 and other proteins to form the death inducing signalling complex (DISC).This thesis describes an investigation of the structure and function of the cytoplasmic Fas-DD. A model for the solution structure of the Fas-DD was published in 1996, it has since been reported that the death domain can form at least one other conformation when in complex with FADD. As a foundation to the work in this thesis, modern multidimensional NMR techniques have been used to solve the structure of the FasDD, to further probe the potential for alternative conformations. It has previously been reported that Fas can be phosphorylated at Tyr291, providing a platform for the recruitment of binding partners that can affect non-apoptotic signalling. The second part of this thesis details the development of an expressed protein ligation methodology to prepare a Tyr291 phosphorylated Fas DD to provide a basis for in vitro studies of the structural, dynamic and functional effects of phosphorylation. It is widely accepted that Fas is palmitoylated at Cys199 and recognised by the membrane cytoskeletal protein, ezrin. Fas palmitoylation is important for clathrinmediated internalisation of the DISC, and amplification of the caspase cascade. There are multiple reports detailing the binding of ezrin to Fas, but it is not clear whether this interaction occurs in a palmitoylation-dependent manner. Efforts to characterise an interaction between bacterially expressed intracellular Fas and ezrin proteins were carried out using a number of biophysical assays, described in the third part of this thesis. Building upon this, the fourth section explores the preparation of a palmitoylated Fas construct suitable for biophysical analysis by incubating recombinant Fas with palmitoyl-CoA
Abordaje quirúrgico y no quirúrgico de la regeneración de la papila interdental
No full textLa papila interdental es el tejido gingival que ocupa el espacio dental interproximal, ésta juega un papel determinante en la sonrisa, además de su función como barrera protectora del tejido periodontal, también interviene en la fonación y evita la impactación de restos alimenticios, su ausencia genera la aparición de triángulos negros, los cuales se han catalogado como uno de los factores más negativos en la estética dental y de la sonrisa. La ausencia de la papila interdental tiene un origen multifactorial, lograr su reconstrucción completa es un desafío, por lo que se requiere de un diagnóstico adecuado y un enfoque multidisciplinario. Diferentes modalidades de tratamiento han sido propuestas, clasificándose en tratamientos no quirúrgicos (corrección de higiene oral traumática, técnicas restaurativas, movimientos ortodóncicos, curetaje repetitivo de la papila, procedimientos de aumento del volumen papilar ) y quirúrgicos. En esta revisión se define la papila interdental y los factores que la pueden alterar, con el fin de buscar estrategias que lleven a tener pronósticos más favorables en los casos donde se observa su pérdida, respondiendo así a mejorar la demanda tanto estética como funcional de los pacientes en relación con la expresión de su [email protected]@campusucc.edu.c
