468 research outputs found
Breaking Dichotomies: Counter-Narratives in the Spoken Word Poetry of Suheir Hammad
No full textThis article analyzes the spoken word poetry of the Palestinian-American author, Suheir Hammad, who attempts to deconstruct dichotomies between Arabs and Americans and to create a concept of transnational humanness. Through cultural criticism, Hammad reverses the process of Othering when she humanizes Palestinians and detaches suffering from national belonging. Her creative resistance represents a renegotiation of Americaness and its relation to Islam and Arabs, and opens up de-nationalized spaces of comparison
Where are the mothers? Interrogating maternal mortality as a violation of the rights to life and health : a Nigerian and Ethiopian perspective
No full textA Dissertation submitted to the Faculty of Law University of Pretoria, in partial fulfilment of the requirements for the degree Masters of Law (LLM in Human Rights and Democratisation in Africa). Prepared under the supervision of Dr. Salah Hammad, Faculty of Law, Addis Ababa University, AddisThesis (LLM (Human Rights and Democratisation in Africa))--University of Pretoria, 2009.The author argues that maternal mortality can easily be avoided and that the right to health and life is as much a developmental issue as it is one of human rights. Focuses on the maternal mortality ratio and relevant laws protecting women’s right to life and health in Nigeria and Ethiopia.http://www.chr.up.ac.za/Centre for Human RightsLL
The role of DC subsets in respiratory viral infections and vaccination : a case of mistaken identity
No full textImmune activation at the lung epithelial barrier
No full textDendritic cells (DCs) are commonly known as the most potent antigen presenting cells in several inflammatory diseases. In the lung the main function of DCs is to sample incoming antigens, transport them to the draining lymph nodes, where they will activate naïve T cells to become effector T cells or regulatory T cells. The outcome of the response depends on the type of antigen, the type of instructing signals encountered in the periphery but also on the nature of the dendritic cell subsets presenting the antigen to T cells.
In chapter 3 we have tried to understand the immune response developed towards antigens trapped in the lung vascular filter. We have shown that these antigens were presented to T cells by interstitial lung DCs in the mediastinal lymph nodes. In addition, we found that these interstitial lung DCs secrete monocyte-chemotactic protein-1 (MCP-1) after embolic antigen exposure, leading to the recruitment of monocytes. Deletion of interstitial DCs resulted in reduced inflammatory aggregates in the lung and antigen presentation in the MLN. Adoptive transfer of purified bone marrow monocytes into DC- depleted mice resulted in conversion of injected monocytes into monocyte-derived DCs and presentation of the antigen in the MLN.
In chapter 4 we describe that bile acid ursodeoxycholic acid (UDCA) has immune regulatory properties by directly acting on the nuclear farnesoid X receptor on DCs. Treatment with UDCA during the secondary immune responses resulted in reduced features of allergic airway inflammation. Recent studies revealed an important role for structural cells, especially epithelial cells, in allergic asthma. Lung epithelial cells express pattern recognition receptors (such as TLR4) and respond to allergens by producing DC-instructing factors. Chapter 5 demonstrates that exposure of lung epithelial cells to HDM leads to release of uric acid (UA). Secreted UA acts as a danger signal to promote Th2 immune responses to harmless inhaled antigens. UA-driven responses were mediated by DCs through Syk and PI3Kd signalling pathway. Treatment of mice with uricase at the time of HDM sensitization reduced the features of allergic airway inflammation.
Chapter 6 shows that after HDM exposure, IL-1a is one of the key cytokines released by epithelial cells and acts in an autocrine loop to enhance Th2 inflammatory responses. Signalling through the IL-1a/IL-1RI pathway induces the secretion of various chemokines and Th2 instructing cytokines by lung epithelial cells. We found that IL-1a induced production of IL-33 and GM-CSF by lung epithelial cells. These two cytokines were found to be crucial in driving Th2 immunity to HDM. Unexpectedly, we also found that epithelial-derived thymic-stromal lymphopoietin (TSLP) did not play a role in a mild model of HDM-induced asthma. However, the use of higher doses of HDM (inducing more severe asthma features) revealed a more important role for TSLP.
In conclusion, this thesis shows that lung DCs are important for the sampling of antigens in different lung compartments. In some cases, like upon exposure to inhaled allergen such as HDM, epithelial cell-derived factors control DC-induced responses. This crosstalk between epithelial cells and DCs involves cytokines such as IL-1a, IL-33 and GM-CSF but also endogenous danger signals like uric acid. Our findings place airway epithelial cells at the origin of Th2 sensitization and therefore, airway epithelial cells can be considered as a therapeutic target for allergic asthma
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