5 research outputs found
A role for Drosophila ATX2 in activation of PER translation and circadian behavior
No full textCo-author Jinli Ling is a student in the Program in Neuroscience in the Morningside Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.A negative transcriptional feedback loop generates circadian rhythms in Drosophila. PERIOD (PER) is a critical state-variable in this mechanism, and its abundance is tightly regulated. We found that the Drosophila homolog of ATAXIN-2 (ATX2)--an RNA-binding protein implicated in human neurodegenerative diseases--was required for circadian locomotor behavior. ATX2 was necessary for PER accumulation in circadian pacemaker neurons and thus determined period length of circadian behavior. ATX2 was required for the function of TWENTY-FOUR (TYF), a crucial activator of PER translation. ATX2 formed a complex with TYF and promoted its interaction with polyadenylate-binding protein (PABP). Our work uncovers a role for ATX2 in circadian timing and reveals that this protein functions as an activator of PER translation in circadian neurons.Neuroscienc
Numerical solution of fractional diffusion-wave equation based on fractional multistep method
No full textThis paper is devoted to application of fractional multistep method in the numerical solution of fractional diffusion-wave equation. By transforming the diffusion-wave equation into an equivalent integro-differential equation and applying Lubich's fractional multistep method of second order we obtain a scheme of order O(tau(alpha) + h(2)) for 1 <= alpha <= 1.71832 where a is the order of temporal derivative and tau and h denote temporal and spatial stepsizes. The solvability, convergence and stability properties of the algorithm are investigated and numerical experiment is carried out to verify the feasibility of the scheme. Crown Copyright (C) 2014 Published by Elsevier Inc. All rights reserved.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000337866800019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Engineering, MultidisciplinaryMathematics, Interdisciplinary ApplicationsMechanicsSCI(E)[email protected]; [email protected]
After Sulla: study in the settlement and material culture of the Piraeus peninsula in the Roman and Late Roman period
No full textModem text-based and ancient historical accounts take the sack of Piraeus, the port of Athens in Greece, by the Romans under Sulla in 86 ВС as the terminal point of the history of the area in antiquity. Archaeological work on the town has tended so far to regard the post-Classical phases of the settlement as less interesting than those marking the 'heyday' of the port in the Classical period. This thesis explores the nature and scale of settlement in the area in the centuries spanning the town's destruction by the Romans in 86 ВС and the Late Roman period. The study is based on a re-assessment of archaeological data from old and recent rescue excavations in the modem town up to 1997. It also presents and discusses in detail the results of post-excavation work by the author on unpublished material from an extensive site excavated in the early 1980s, These results are compared to and synthesized with epigraphic and other testimonies to answer questions about the nature of settlement and the degree of social and cultural change in the area during the period in focus. The discussion focuses in particular on; 1) exploring continuity and change in the settlement patterns, demography and topography of the town, 2) the changing nature of domestic space and its organization, and 3) investigating patterns of pottery consumption and trade. These issues are examined in the context of the social, economic and cultural changes documented for the Roman imperial and Late Roman period by previous archaeological fieldwork and excavations in the region of southern Greece and the Aegean
Early Neutrophilia Marked by Aerobic Glycolysis Sustains Host Metabolism and Delays Cancer Cachexia
No full textAn elevated neutrophil–lymphocyte ratio negatively predicts the outcome of patients with cancer and is associated with cachexia, the terminal wasting syndrome. Here, using murine model systems of colorectal and pancreatic cancer we show that neutrophilia in the circulation and multiple organs, accompanied by extramedullary hematopoiesis, is an early event during cancer progression. Transcriptomic and metabolic assessment reveals that neutrophils in tumor-bearing animals utilize aerobic glycolysis, similar to cancer cells. Although pharmacological inhibition of aerobic glycolysis slows down tumor growth in C26 tumor-bearing mice, it precipitates cachexia, thereby shortening the overall survival. This negative effect may be explained by our observation that acute depletion of neutrophils in pre-cachectic mice impairs systemic glucose homeostasis secondary to altered hepatic lipid processing. Thus, changes in neutrophil number, distribution, and metabolism play an adaptive role in host metabolic homeostasis during cancer progression. Our findings provide insight into early events during cancer progression to cachexia, with implications for therapy
Fachkatalog Neuguinea / Stadt- und Universitätsbibliothek Frankfurt am Main
No full textAus Anlaß des Kongresses der "Deutsch-Pazifischen Gesellschaft" im Juni 1981 in Düsseldorf legt die Stadt- und Universitätsbibliothek Frankfuxt am Main ein Verzeichnis ihrer Bestände zum Raum "Neuguinea" vor . Dabei umfaßt der Katalog sowohl die Literatur zu "Papua-Neuguinea" (Niugini)" als auch zur indonesischen Provinz "West-Irian (Irian Jaya)". Aus Gründen des geographischen Zusammenhangs werden in einem Anhang allgemeine Publikationen zum Raum Melanesien in den Katalog aufgenommen. Die gezielte Sammlung der Literatur zu diesem Raum ist ein Ergebnis der Zuweisung des Sondersarnmelgebietes "Ozeanian" durch die Deutsche Forschungagemeinschaft an die Frankfurter Stadt- und Univeraitätsbibliothek. Dabei liegt der Schwerpunkt auf der Sammlung historischer und ethnologischer Literatur. Grundlage des Katalogausdruckes ist der Länderteil des Sachkataloges der Bibliothek, der nach feststehenden Länderkennziffern, Fachgruppen und Schlüsselnummern gegliedert ist. Unter jeder Schlüsselnummer sind die Eintragungen chronologisch geordnet. Auf jeder Titelkarte befindet sich rechts oben die Signatur, unter der das Buch über Fernleihe bei der Stadt- und Universitätsbibliothek Frankfurt am Main bestellt werden kann
