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Vassar Miller prize in poetry series
No full textWith poems that combine the self-scrutiny of Philip Larkin with the measure of Elizabeth Bishop, Amy M. Clark burnishes her first collection, Stray Home, with exquisite understatement and formal control. Sweeter than Larkin and more intimate than Bishop, these poems address the suppressed pain and shame of living as a childless woman in a world of mothers, the dissociation attendant on depression and fraught family relationships, and the search for a sense of belonging in the face of dislocation. Stray Home cuts deeply to discover the buried emotions and insights universal to all suffering and compassionate human beings. “Clark is able to imbue our small, usually overlooked moments with unexpected grandeur. A quiet humor is employed in service of her twin gifts, imagination and metaphor. This is an accomplished, deft, and important debut.”—Beth Ann Fennelly, author of Tender Hooks and judg
Review of Jews, Gentiles, and Other Animals: The Talmud After the Humanities, by Mira Beth Wasserman
No full textMira Beth Wasserman's thoroughly researched and beautifully written monograph is an ambitious foray by a Talmud scholar into the diverse, often-fractious, and notoriously difficult jungle of critical theory. Wasserman's project has a number of moving parts, but essentially, it is a sustained reading of the entirety of the Babylonian Talmud tractate Avodah Zara (hereafter, "AZ") as a literary whole. She argues that a close reading of the tractate reveals the Bavli's redactors not as disinterested editors working merely to preserve texts they received, but as artists in their own right, carefully organizing the material in AZ under "an overarching plan or an undergirding logic" (p. 23)
Analyzing venture capitol influence on startup success : a people-centric network theory approach
No full textThesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2017.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 79-82).In this thesis, we study the impact of venture capitalists on startup success using social network analysis. Using multiple sources, we compile a unique dataset of 3199 US-based technology startups and their board members, from which we generate and analyze the interlocking directorates network (formal network) and Twitter network (informal network). We find that startups with more VC board members are more central in the formal network, receive greater funding, have greater annual sales, yet a smaller return-on-investment. We also find that VCs are more central in the Twitter network than non-VCs, have greater Twitter popularity, yet tweet significantly less. Our results indicate that VCs carry a considerable amount of financial and social capital, which they transmit to the startups they invest in, yet their participation leads to lower startup ROI. Additionally, our dataset enabled us to investigate more general questions regarding startup success, including gender diversity on startup boards..by Beth M. Hadley.M. Eng
Beth Levine in memoriam
No full textBeth Levine was born on 7 April 1960 in Newark, New Jersey. She went to college at Brown University where she received an A.B. Magna Cum Laude, and she attended medical school at Cornell University Medical College, receiving her MD in 1986. She completed her internship and residency in Internal Medicine at Mount Sinai Hospital in New York, and her fellowship in Infectious Diseases at The Johns Hopkins Hospital. Most recently, Beth was a Professor of Internal Medicine and Microbiology, Director of the Center for Autophagy Research, and holder of the Charles Sprague Distinguished Chair in Biomedical Science at the University of Texas Southwestern Medical Center in Dallas. Beth died on 15 June 2020 from cancer. Beth is survived by her husband, Milton Packer, and their two children, Rachel (26 years old) and Ben (25 years old).
Dr. Levine was as an international leader in the field of autophagy research. Her laboratory identified the mammalian autophagy gene BECN1/beclin 1; identified conserved mechanisms underlying the regulation of autophagy (e.g. BCL2-BECN1 complex formation, insulin-like signaling, EGFR, ERBB2/HER2 and AKT1-mediated BECN1 phosphosphorylation); and provided the first evidence that autophagy genes are important in antiviral host defense, tumor suppression, lifespan extension, apoptotic corpse clearance, metazoan development, Na,K-ATPase-regulated cell death, and the beneficial metabolic effects of exercise. She developed a potent autophagy-inducing cell permeable peptide, Tat-beclin 1, which has potential therapeutic applications in a range of diseases. She was a founding Associate Editor of the journal Autophagy and an editorial board member of Cell and Cell Host & Microbe. She has received numerous awards/honors in recognition of her scientific achievement, including: The American Cancer Society Junior Faculty Research Award (1994); election into the American Society of Clinical Investigation (2000); the Ellison Medical Foundation Senior Scholars Award in Global Infectious Diseases (2004); elected member, American Association of Physicians (2005); appointment as a Howard Hughes Medical Institute Investigator (2008); Edith and Peter O’Donnell Award in Medicine (2008); elected fellow, American Association for the Advancement of Science (2012); election into the National Academy of Sciences (2013); election into the Academy of Medicine, Engineering and Science of Texas (2013); the ASCI Stanley J. Korsmeyer Award (2014); Phyllis T. Bodel Women in Medicine Award, Yale University School of Medicine (2018); recipient, Barcroft Medal, Queen’s University Belfast (2018).Fil: An, Zhenyi. No especifíca;Fil: Ballabi, Andrea. No especifíca;Fil: Bennett, Lynda. No especifíca;Fil: Boya, Patricia. No especifíca;Fil: Cecconi, Francesco. No especifíca;Fil: Chiang, Wei Chung. No especifíca;Fil: Codogno, Patrice. No especifíca;Fil: Colombo, Maria Isabel. No especifíca;Fil: Cuervo, Ana Maria. No especifíca;Fil: Debnath, Jayanta. No especifíca;Fil: Deretic, Vojo. No especifíca;Fil: Dikic, Ivan. No especifíca;Fil: Dionne, Keith. No especifíca;Fil: Dong, Xiaonan. No especifíca;Fil: Elazar, Zvulun. No especifíca;Fil: Galluzzi, Lorenzo. No especifíca;Fil: Gentile, Frank. No especifíca;Fil: Griffin, Diane E.. No especifíca;Fil: Hansen, Malene. No especifíca;Fil: Hardwick, J. Marie. No especifíca;Fil: He, Congcong. No especifíca;Fil: Huang, Shu Yi. No especifíca;Fil: Hurley, James. No especifíca;Fil: Jackson, William T.. No especifíca;Fil: Jozefiak, Cindy. No especifíca;Fil: Kitsis, Richard N.. No especifíca;Fil: Klionsky, Daniel J.. No especifíca;Fil: Kroemer, Guido. No especifíca;Fil: Meijer, Alfred J.. No especifíca;Fil: Meléndez, Alicia. No especifíca;Fil: Melino, Gerry. No especifíca;Fil: Mizushima, Noboru. No especifíca;Fil: Murphy, Leon O.. No especifíca;Fil: Nixon, Ralph. No especifíca;Fil: Orvedahl, Anthony. No especifíca;Fil: Pattingre, Sophie. No especifíca;Fil: Piacentini, Mauro. No especifíca;Fil: Reggiori, Fulvio. No especifíca;Fil: Ross, Theodora. No especifíca;Fil: Rubinsztein, David C.. No especifíca;Fil: Ryan, Kevin. No especifíca;Fil: Sadoshima, Junichi. No especifíca;Fil: Schreiber, Stuart L.. No especifíca;Fil: Scott, Frederick. No especifíca;Fil: Sebti, Salwa. No especifíca;Fil: Shiloh, Michael. No especifíca;Fil: Shoji, Sanae. No especifíca;Fil: Simonsen, Anne. No especifíca;Fil: Smith, Haley. No especifíca;Fil: Sumpter, Kathryn M.. No especifíca;Fil: Thompson, Craig B.. No especifíca;Fil: Thorburn, Andrew. No especifíca;Fil: Thumm, Michael. No especifíca;Fil: Tooze, Sharon. No especifíca;Fil: Vaccaro, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Virgin, Herbert W.. No especifíca;Fil: Wang, Fei. No especifíca;Fil: White, Eileen. No especifíca;Fil: Xavier, Ramnik J.. No especifíca;Fil: Yoshimori, Tamotsu. No especifíca;Fil: Yuan, Junying. No especifíca;Fil: Yue, Zhenyu. No especifíca;Fil: Zhong, Qing. No especifíca
Visualizing Music
No full textDue to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to [email protected], referencing the URI of the item.Includes bibliographical references.Issued also on microfiche from Lange Micrographics.A process of experientially deriving visual information from music is described. The author describes her methodology behind the translation of a music composition to a computer animation. The methodology described could be adapted and applied to translate between other art forms. The process of translating a work is annotated from original conception to final product. Other artists who work in the field and future outlets for this research are also discussed
Acute Ethanol Administration Rapidly Increases Phosphorylation of Conventional Protein Kinase C in Specific Mammalian Brain Regions in Vivo
No full textBackground
Protein kinase C (PKC) is a family of isoenzymes that regulate a variety of functions in the central nervous system including neurotransmitter release, ion channel activity, and cell differentiation. Growing evidence suggests that specific isoforms of PKC influence a variety of behavioral, biochemical, and physiological effects of ethanol in mammals. The purpose of this study was to determine whether acute ethanol exposure alters phosphorylation of conventional PKC isoforms at a threonine 674 (p-cPKC) site in the hydrophobic domain of the kinase, which is required for its catalytic activity.
Methods
Male rats were administered a dose range of ethanol (0, 0.5, 1, or 2 g/kg, intragastric) and brain tissue was removed 10 minutes later for evaluation of changes in p-cPKC expression using immunohistochemistry and Western blot methods.
Results
Immunohistochemical data show that the highest dose of ethanol (2 g/kg) rapidly increases p-cPKC immunoreactivity specifically in the nucleus accumbens (core and shell), lateral septum, and hippocampus (CA3 and dentate gyrus). Western blot analysis further showed that ethanol (2 g/kg) increased p-cPKC expression in the P2 membrane fraction of tissue from the nucleus accumbens and hippocampus. Although p-cPKC was expressed in numerous other brain regions, including the caudate nucleus, amygdala, and cortex, no changes were observed in response to acute ethanol. Total PKC? immunoreactivity was surveyed throughout the brain and showed no change following acute ethanol injection
An observational feasibility study to assess the safety and effectiveness of intranasal fentanyl for radiofrequency ablations of the lumbar facet joints
No full textMichael W Bartoszek,1 Amy McCoart,2 Kyung-soo Jason Hong,3 Chelsey Haley,2 Krista Beth Highland,4 Anthony R Plunkett1 1Department of Anesthesiology, Womack Army Medical Center, Fort Bragg, NC, 2Clinical Investigations, Defense and Veterans Center for Integrative Pain Management, Henry M. Jackson Foundation, Womack Army Medical Center, Fort Bragg, NC, 3Research Department, The Center for Clinical Research, Sceptor Pain Foundation, Winston Salem, NC, 4Defense and Veterans Center for Integrative Pain Management, Henry M. Jackson Foundation, Uniformed Services University, Bethesda, MD, USA Purpose: The purpose of the present observational, feasibility study is to assess the preliminary safety and effectiveness of intranasal fentanyl for lumbar facet radiofrequency ablation procedures.Patients and methods: This cohort observational study included 23 adult patients. Systolic and diastolic blood pressures, heart rate, oxygen saturation percent, Pasero Opioid-Induced Sedation Scale score, and the Defense and Veterans Pain Rating Scale pain score were assessed prior to the procedure and intranasal fentanyl (100 μg) administration and every 15 minutes after administration, up to 60 minutes post administration. Follow-up of patient satisfaction with pain control and treatment was assessed 24 hours after discharge. The primary outcome was safety as evidenced by adverse events. Secondary outcomes included the above-mentioned vital signs and pain ratings.Results: No adverse events occurred in the present study and all participants maintained an acceptable level of awareness throughout the assessment period. One-way repeated measures analyses of covariance tests with Bonferroni-adjusted means indicated that oxygen saturation, blood pressure, and heart rate changed from baseline, whereas pain scores were lower at post-administration levels compared with baseline. Finally, the majority of participants reported being satisfied with pain control and treatment.Conclusion: Preliminary evidence indicates that intranasal fentanyl is safe and effective for lumbar facet radiofrequency ablation procedures. Future rigorous randomized control trials are needed to confirm the present results and to examine the effects of intranasal fentanyl on intraoperative and postoperative opioid use. Keywords: analgesia, spinal procedures, chronic pain, sedatio
Characterization of Self-Consolidating Concrete for the Design of Precast, Pretensioned Bridge Superstructure Elements
No full textSelf-consolidating concrete (SCC) is a new, innovative construction material that
can be placed into forms without the need for mechanical vibration. The mixture
proportions are critical for producing quality SCC and require an optimized combination
of coarse and fine aggregates, cement, water, and chemical and mineral admixtures. The
required mixture constituents and proportions may affect the mechanical properties,
bond characteristics, and long-term behavior, and SCC may not provide the same inservice
performance as conventional concrete (CC). Different SCC mixture constituents
and proportions were evaluated for mechanical properties, shear characteristics, bond
characteristics, creep, and durability. Variables evaluated included mixture type (CC or
SCC), coarse aggregate type (river gravel or limestone), and coarse aggregate volume.
To correlate these results with full-scale samples and investigate structural behavior
related to strand bond properties, four girder-deck systems, 40 ft (12 m) long, with CC
and SCC pretensioned girders were fabricated and tested.
Results from the research indicate that the American Association of State
Highway Transportation Officials Load and Resistance Factor Design (AASHTO
LRFD) Specifications can be used to estimate the mechanical properties of SCC for a
concrete compressive strength range of 5 to 10 ksi (34 to 70 MPa). In addition, the
research team developed prediction equations for concrete compressive strength ranges
from 5 to 16 ksi (34 to 110 MPa). With respect to shear characteristics, a more appropriate expression is proposed to estimate the concrete shear strength for CC and
SCC girders with a compressive strength greater than 10 ksi (70 MPa). The author found
that girder-deck systems with Type A SCC girders exhibit similar flexural performance
as deck-systems with CC girders. The AASHTO LRFD (2006) equations for computing
the cracking moment, nominal moment, transfer length, development length, and
prestress losses may be used for SCC girder-deck systems similar to those tested in this
study. For environments exhibiting freeze-thaw cycles, a minimum 16-hour release
strength of 7 ksi (48 MPa) is recommended for SCC mixtures
Rainbow perspectives: a case study exploring perceptions and experiences of students in a queer focused special interest housing community
No full textThere are more out queer undergraduate students stepping foot onto colleges campuses across the nation than ever before (D’Augelli & Hershberger, 1993; Grov, Bimbi, Nanin, & Parsons, 2006; PFLAG, 2001; Sanlo, 2005). Although the college experience is designed to be a time of great challenge and development resulting in considerable reward, queer students are working towards this reward with added complexity. The importance of visible and easily accessible support networks is heightened as queer students are feeling isolated and alone on college campuses. Campus climate statistics have gone a long way in describing the chilly campus environments queer students face (Rankin, 2003). However, there is not as much information about specific institutional support strategies designed to support and provide awareness about the queer community. Special interest housing communities are one such strategy. This qualitative case study examined the experiences and perceptions of queer students living in a queer focused special interest housing community at a large research extensive university in the northeast United States. The purpose of this study is to provide real voices and stories to campus climate statistics and to inform the practice of student affairs professionals.Ed.D.Includes bibliographical referencesby Sarah Beth Baile
Detection and localization of aerosol releases from sparse sensor measurements
No full textThesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2005.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Includes bibliographical references (p. 111-114).In this thesis we focus on addressing two aspects pertinent to biological release detection. The first is that of detecting and localizing an aerosolized particle release using a sparse array of sensors. The problem is challenging for several reasons. It is often the case that sensors are costly and consequently only a sparse deployment is possible. Additionally, while dynamic models can be formulated in many environmental conditions, the underlying model parameters may not be precisely known. The combination of these two issues impacts the effectiveness of inference approaches. We restrict ourselves to propagation models consisting of diffusion plus transport according to a Gaussian puff model. We derive optimal inference algorithms utilizing sparse sensor measurements, provided the model parameterization is known precisely. The primary assumptions are that the mean wind field is deterministically known and that the Gaussian puff model is valid. Under these assumptions, we characterize the change in performance of detection, time-to-detection and localization as a function of the number of sensors. We then examine some performance impacts when the underlying dynamical model deviates from the assumed model. In addition to detecting an abrupt change in particles in an environment, it is also important to be able to classify the releases as not all contaminants are of interest. For this reason, the second aspect of addressed is feature extraction, a stage where sensor measurements are reduced to a set of pertinent features that can be used as an input to the classifier.(cont.) Shift invariance of the feature set is critical and thus the Dual Tree Complex Wavelet Transform (DT CWT) is proposed as the wavelet feature domain.by Emily Beth Fox.M.Eng
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