3,974 research outputs found
Supplemental material for Increasing cerebral blood flow improves cognition into late stages in Alzheimer’s disease mice
No full textSupplemental Material for Increasing cerebral blood flow improves cognition into late stages in Alzheimer’s disease mice by Oliver Bracko, Brendah N Njiru, Madisen Swallow, Muhammad Ali, Mohammad Haft-Javaherian and Chris B Schaffer in Journal of Cerebral Blood Flow & Metabolism</p
Data from: Deep convolutional neural networks for segmenting 3D in vivo multiphoton images of vasculature in Alzheimer disease mouse models
No full textThe health and function of tissue rely on its vasculature network to provide reliable blood perfusion. Volumetric imaging approaches, such as multiphoton microscopy, are able to generate detailed 3D images of blood vessels that could contribute to our understanding of the role of vascular structure in normal physiology and in disease mechanisms. The segmentation of vessels, a core image analysis problem, is a bottleneck that has prevented the systematic comparison of 3D vascular architecture across experimental populations. We explored the use of convolutional neural networks to segment 3D vessels within volumetric in vivo images acquired by multiphoton microscopy. We evaluated different network architectures and machine learning techniques in the context of this segmentation problem. We show that our optimized convolutional neural network architecture, which we call DeepVess, yielded a segmentation accuracy that was better than both the current state-of-the-art and a trained human annotator, while also being orders of magnitude faster. To explore the effects of aging and Alzheimer's disease on capillaries, we applied DeepVess to 3D images of cortical blood vessels in young and old mouse models of Alzheimer's disease and wild type littermates. We found little difference in the distribution of capillary diameter or tortuosity between these groups, but did note a decrease in the number of longer capillary segments (>75μm) in aged animals as compared to young, in both wild type and Alzheimer's disease mouse models. These data support these findings.This work was supported by the European Research Council grant 615102 (NN), the National Institutes of Health grant AG049952 (CS), the National Institutes of Health grants R01LM012719 and R01AG053949 (MS), and the National Science Foundation Cornell NeuroNex Hub grant (1707312, MS and CS)
Virtual Microstructure Generation of Asphaltic Mixtures
No full textThis thesis describes the development and application of a virtual microstructure generator incorporated with post-processing image analysis methods that can be used to fabricate a virtual, two-dimensional microstructure of asphaltic mixtures. In the generator, geometrical characteristics such as aggregate gradation, aggregate area fraction, angularity, orientation, and elongation were used to transform data from a three-dimensional (3D) mixture into its two-dimensional (2D) microstructure. The 2D virtual microstructures were generated from real 3D mixture information of asphaltic composites. Resulting virtual microstructures were then compared to real cross-sectional microstructure images obtained from actual samples for validation. Comparison presented a good agreement between the virtual and real microstructures, which demonstrates that the new 3D-2D transformation algorithms were properly developed and implemented into the virtual microstructure generator. Although much future work is required, the current development is at least sufficient to demonstrate the benefits and potential of this effort. Virtual fabrication and testing can result in significant time and cost savings compared to more expensive and repetitive laboratory fabrication and performance tests of actual specimens.
Adviser: Yong-Rak Ki
QUANTITATIVE ASSESSMENT OF CEREBRAL MICROVASCULATURE USING MACHINE LEARNING AND NETWORK ANALYSIS
No full textVasculature networks are responsible for providing reliable blood perfusion to tissues in health or disease conditions. Volumetric imaging approaches, such as multiphoton microscopy, can generate detailed 3D images of blood vessel networks allowing researchers to investigate different aspects of vascular structures and networks in normal physiology and disease mechanisms. Image processing tasks such as vessel segmentation and centerline extraction impede research progress and have prevented the systematic comparison of 3D vascular architecture across large experimental populations in an objective fashion. The work presented in this dissertation provides complete a fully-automated, open-source, and fast image processing pipeline that is transferable to other research areas and practices with minimal interventions and fine-tuning. As a proof of concept, the applications of the proposed pipeline are presented in the contexts of different biomedical and biological research questions ranging from the stalling capillary phenomenon in Alzheimer’s disease to the drought resistance of xylem networks in various tree species and wood types
Mathematics, Logic, and their Philosophies:Essays in Honour of Mohammad Ardeshir
No full textThis volume is a collection of essays in honour of Professor Mohammad Ardeshir. It examines topics which, in one way or another, are connected to the various aspects of his multidisciplinary research interests. Based on this criterion, the book is divided into three general categories. The first category includes papers on non-classical logics, including intuitionistic logic, constructive logic, basic logic, and substructural logic. The second category is made up of papers discussing issues in the contemporary philosophy of mathematics and logic. The third category contains papers on Avicenna’s logic and philosophy.Mohammad Ardeshir is a full professor of mathematical logic at the Department of Mathematical Sciences, Sharif University of Technology, Tehran, Iran, where he has taught generations of students for around a quarter century. Mohammad Ardeshir is known in the first place for his prominent works in basic logic and constructive mathematics. His areas of interest are however much broader and include topics in intuitionistic philosophy of mathematics and Arabic philosophy of logic and mathematics. In addition to numerous research articles in leading international journals, Ardeshir is the author of a highly praised Persian textbook in mathematical logic. Partly through his writings and translations, the school of mathematical intuitionism was introduced to the Iranian academic community
Mathematics, Logic, and their Philosophies:Essays in Honour of Mohammad Ardeshir
No full textThis volume is a collection of essays in honour of Professor Mohammad Ardeshir. It examines topics which, in one way or another, are connected to the various aspects of his multidisciplinary research interests. Based on this criterion, the book is divided into three general categories. The first category includes papers on non-classical logics, including intuitionistic logic, constructive logic, basic logic, and substructural logic. The second category is made up of papers discussing issues in the contemporary philosophy of mathematics and logic. The third category contains papers on Avicenna’s logic and philosophy.Mohammad Ardeshir is a full professor of mathematical logic at the Department of Mathematical Sciences, Sharif University of Technology, Tehran, Iran, where he has taught generations of students for around a quarter century. Mohammad Ardeshir is known in the first place for his prominent works in basic logic and constructive mathematics. His areas of interest are however much broader and include topics in intuitionistic philosophy of mathematics and Arabic philosophy of logic and mathematics. In addition to numerous research articles in leading international journals, Ardeshir is the author of a highly praised Persian textbook in mathematical logic. Partly through his writings and translations, the school of mathematical intuitionism was introduced to the Iranian academic community
Mathematics, Logic, and their Philosophies:Essays in Honour of Mohammad Ardeshir
No full textThis volume is a collection of essays in honour of Professor Mohammad Ardeshir. It examines topics which, in one way or another, are connected to the various aspects of his multidisciplinary research interests. Based on this criterion, the book is divided into three general categories. The first category includes papers on non-classical logics, including intuitionistic logic, constructive logic, basic logic, and substructural logic. The second category is made up of papers discussing issues in the contemporary philosophy of mathematics and logic. The third category contains papers on Avicenna’s logic and philosophy.Mohammad Ardeshir is a full professor of mathematical logic at the Department of Mathematical Sciences, Sharif University of Technology, Tehran, Iran, where he has taught generations of students for around a quarter century. Mohammad Ardeshir is known in the first place for his prominent works in basic logic and constructive mathematics. His areas of interest are however much broader and include topics in intuitionistic philosophy of mathematics and Arabic philosophy of logic and mathematics. In addition to numerous research articles in leading international journals, Ardeshir is the author of a highly praised Persian textbook in mathematical logic. Partly through his writings and translations, the school of mathematical intuitionism was introduced to the Iranian academic community
Mathematics, Logic, and their Philosophies:Essays in Honour of Mohammad Ardeshir
No full textThis volume is a collection of essays in honour of Professor Mohammad Ardeshir. It examines topics which, in one way or another, are connected to the various aspects of his multidisciplinary research interests. Based on this criterion, the book is divided into three general categories. The first category includes papers on non-classical logics, including intuitionistic logic, constructive logic, basic logic, and substructural logic. The second category is made up of papers discussing issues in the contemporary philosophy of mathematics and logic. The third category contains papers on Avicenna’s logic and philosophy.Mohammad Ardeshir is a full professor of mathematical logic at the Department of Mathematical Sciences, Sharif University of Technology, Tehran, Iran, where he has taught generations of students for around a quarter century. Mohammad Ardeshir is known in the first place for his prominent works in basic logic and constructive mathematics. His areas of interest are however much broader and include topics in intuitionistic philosophy of mathematics and Arabic philosophy of logic and mathematics. In addition to numerous research articles in leading international journals, Ardeshir is the author of a highly praised Persian textbook in mathematical logic. Partly through his writings and translations, the school of mathematical intuitionism was introduced to the Iranian academic community
Mathematics, Logic, and their Philosophies:Essays in Honour of Mohammad Ardeshir
No full textThis volume is a collection of essays in honour of Professor Mohammad Ardeshir. It examines topics which, in one way or another, are connected to the various aspects of his multidisciplinary research interests. Based on this criterion, the book is divided into three general categories. The first category includes papers on non-classical logics, including intuitionistic logic, constructive logic, basic logic, and substructural logic. The second category is made up of papers discussing issues in the contemporary philosophy of mathematics and logic. The third category contains papers on Avicenna’s logic and philosophy.Mohammad Ardeshir is a full professor of mathematical logic at the Department of Mathematical Sciences, Sharif University of Technology, Tehran, Iran, where he has taught generations of students for around a quarter century. Mohammad Ardeshir is known in the first place for his prominent works in basic logic and constructive mathematics. His areas of interest are however much broader and include topics in intuitionistic philosophy of mathematics and Arabic philosophy of logic and mathematics. In addition to numerous research articles in leading international journals, Ardeshir is the author of a highly praised Persian textbook in mathematical logic. Partly through his writings and translations, the school of mathematical intuitionism was introduced to the Iranian academic community
'Fatherless' of Mohammad Mosavat: The cultural event of the Iranian spring
No full textThe following is a psychoanalytic commentary about a play recently performed in Tehran (Iran) followed by an interview with its author, Mohammad Mosavat. The co-signatories both attended a performance of this play. Invited by Shahid Behesti, Alzahra, and Shiraz Universities for many public lectures and supervisions, the French psychoanalyst Jean-Luc Vannier signs the commentary while the interview and the translation were conducted by the Iranian psychoanalyst in training at the Freudian Group of Tehran, Mahyar Ali Naghi
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