227 research outputs found
Noninvasive treatment for ingrown nails: Anchor taping, acrylic affixed gutter splint, sculptured nail and others.
No full textOn names in Mažuranić’s epic The Death of Smail-Agha Čengić (Smrt Smail-age Čengića)
No full textIako sam o leksikografskoj obradi Mažuranićeve pjesni Smrt Smail-age Čengića već pisao, ostalo je podosta toga o čemu još treba progovoriti. Tom dijelu pripada i rasprava o imenima u Mažuranićevoj Smrti. Ovo je, čini mi se, ponajbolja prigoda da se o tome prozbori u članku koji je posvećen Svečaru.Starting from his overall lexicographic approach to Mažuranić’s epic The Death of Smail-Agha Čengić, the author focuses his attention here on the analysis of its corpus of names. Most studies of the epic to date have not paid special attention to the onomastic material although it was partly incorporated into Benešić’s Dictionary of the Croatian Literary Language. The author believes that a dictionary of words used in an individual literary work or in complete works of an author, i.e. a Writer’s Dictionary, should contain all the words with their meanings, including proper names (anthroponyms, place names and ethnonyms), especially since proper names as a category do not rank very low on a frequency scale. Even if a name appeared only once in a given work (e.g. in Mažuranić’s The Death of Smail-Agha Čengić), it should nevertheless be included in a dictionary. In compiling a complete dictionary of Mažuranić’s poem The Death of Smail- Agha Čengić, the author has found that the poem contains slightly less than 6.000 words (including all word forms), or 1.661 headwords used in 1.134 verses and 5 cantos of the epic: Agovanje, Noćnik, Četa, Harač and Kob. The corpus contains approximately eighty forms of onomastic names and their adjectival derivations, which can be considered as onomastic headwords. The author lists names in the alphabetical order together with the number of their occurrences and variants (in brackets), thus presenting their collocations as well. They will subsequently be listed according to semantic categories and frequency
Abstract 3407: Side effects of BRAF inhibitors mimic RASopathies
No full textAbstract
Recent advances in targeted anticancer therapies have substantially improved the prognosis of several cancers but they are not free of side effects. These side effects are, however, clearly distinct from those induced by classical cytotoxic chemotherapies, likely because targeted therapies are designed to interfere with specific oncogenic signaling pathways and not to inhibit cell proliferation in general. We, therefore, evaluated whether specific side effects of BRAF inhibitor therapies would resemble symptoms seen in patients with RASopathies, in which the MAPK pathway is affected and which includes Costello, Noonan and Cardio-Facio-Cutaneous syndromes. To this end, we collected a cohort of 18 patients with genetically confirmed RASopathies that were followed between 2012 and 2016 at the University Hospital of Rennes, France and that were evaluated based on their personal medical history and a clinical examination. Strikingly, RASopathy patients, particularly those with Cardio-Facio-Cutaneous syndrome, showed symptoms resembling those that we and others have previously seen in genetically characterized patients undergoing BRAF inhibitor treatment. These symptoms included keratosis pilaris, wavy hair, sparse eyelashes/eyebrows, poor hair growth, palmo-plantar hyperkeratosis in areas of pressure, verrucous papillomas, nevi efflorescence, and increased cancer risk. Nevertheless, BRAF-inhibitor treatment can also lead to side effects not typically found in patients with RASopathies, including acneiform dermatitis and vemurafenib-specific phototoxicity, which may even increase under a combined BRAF/MEK inhibition. These results suggest that the side effects of BRAF inhibition that are similar to symptoms in patients with RASopathies are due to direct targeting of the MAPK pathway in BRAF-non-mutated (wild type) cells while those that are dissimilar represent off-target effects that do not affect the MAPK pathway. We hope that this type of comparative analysis may lead to a better understanding of the multiple effects of targeted therapies and perhaps prompt modifications in the targeted therapy approach to minimize these side effects.
Citation Format: Alicia Sfecci, Alain Dupuy, Monica Dinulescu, Catherine Droitcourt, Henri Adamski, Smail Hadj-Rabia, Sylvie Odent, Marie-Dominique Galibert, Lise Boussemart. Side effects of BRAF inhibitors mimic RASopathies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3407. doi:10.1158/1538-7445.AM2017-3407</jats:p
GAVELLA’S READER’S VIEW ON THE POEM DEATH OF SMAIL-AGA ČENGIĆ
No full textThis paper analyses Gavella’s essay called Poetic structure of Mažuranić’s Smail-aga (1961) which, based on the example of canonical literary text, summarizes the author’s principal and theoretical views about the relationship between literature and dramatic performance. Following his insight that dramatization of a literary text, in the first place, requires a reading-interpretative effort kept within the frames of textual analysis of linguistic material, the second part of this paper represents the reading of controversial textual points in Mažuranić’s poem in the light of Gavella’s interpretative guidelines. At the same time, metatextual signals are shown to be essential for understanding Smail-aga, the analysis of the correlation between narrator and author, the status of the storyteller, and the associated shift in understanding of poetic language from constative to performative
ICHTYOSES SYNDROMIQUES (ETUDE CLINIQUE ET IDENTIFICATION D'UNE NOUVELLE FORME LIEE AU CHROMOSOME 3 (DES DERMATOLOGIE VENEREOLOGIE))
No full textPARIS12-CRETEIL BU Médecine (940282101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
VARIATIONS PHYSIOLOGIQUES DU FACTEUR VON WILLEBRAND CHEZ LES DONNEURS DE SANG AU CHU DE TIZI-OUZOU
No full textLe facteur Von Willebrand (VWF) est une glycoprotéine qui joue un rôle crucial dans
l’hémostase, il connait de fortes variations physiologiques qui sont attribuées à de nombreux
facteurs tant génétiques qu’environnementaux.
L’objectif de notre travail est d’identifier ces derniers et de préciser les variations du facteur
de Von Willebrand, l’étude menée chez 68 donneurs de sang (avec un sex-ratio égal à 2,08)
au CHU Nedir Mohamed pour le dosage du VWF par une technique de référence (dosage de
l’activité du cofacteur de la ristocétine).
Les résultats obtenus ont montré que les taux plasmatiques moyens étaient relativement plus
élevés chez les donneurs de sang (>150%) comparés aux valeurs de références
internationales comprises entre [50-150%]. Ces taux étaient significativement plus bas chez
les sujets appartenant au groupe sanguins O (137,53%) par rapport aux autres groupes
(229,26%), et (1,3) fois plus élevés chez les sportifs et chez les fumeurs (212,41%) que chez
les non-fumeurs (116,52%) ; tandis qu’aucune corrélation significative n’a été observée
concernant le sexe (p=0,50), le rhésus D (p=0,7), le stress émotionnel (p=0,40) et la
contraception (p=0,2)
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