16 research outputs found
Hepatoprotactive activity of Ruta chalepensis ethanolic extract and histo-architecture of liver on CCL4 damaged albino male mice
Get PDF Medicines derivative from plants broadly famous owing to their safety, obtainability and little Leaves, roots, bark, kernels and florae of plant are mostly prepared that included herbal medicines. They are administered orally, inhaled or directly applied in the skin. Ruta chalepensis is take on in the outdated medicine of many countries as a natural herb of the Mediterranean region. Pharmacological properties responsible by using phytochemical screening has shown the attendance of bioactive molecules price. The current study meant to investigate the effect of R. chalepensis ethanolic extract on liver function enzyme (Aspartate Amino-Transferase (AST), Alanine Amino-Transferase (ALT) and Alkaline Phosphatase (ALP) and histological examination of liver section. Obtained showed the ability of plant extract to protect liver from any xenobiotics and provided protection against CCL4 damage on albino male mice
In Vivo Study the Cytogenetic Effect of Ammi majus Methanolic Extract on Mitotic Index, Micronucleus Formation and DNA Damage on Mitoxantrone Treated Albino Male Mice
Get PDFصممت هذه الدراسة للكشف عن التاثير الوراثي للمستخلص الميثانولي لنبات الخلة على معامل الانقسام الخلوي,تكون النوى الصغيرة و مدى تاثيره على تحطم الدنا الوراثي في الفئران المستحثة بعقار الميتوزانترون (المضاد للسرطان). استخدمت في هذه الدراسة اربعه مجاميع للفئران: المجموعه الاولى(السيطرة الموجبة )الفئران المعاملة بعقار الميتوزانترون بتركيز (0,008 ملغم\فارة) والمجموعه الثانية (السيطرة السالبة) الفئران الغير معامله اما المجوعه الثالثة والرابعه كانت الفئران المعاملة بالعقار لليومين الاول والثاني ومن اليوم 3 الى 7 عوملت الفئران بالمسخلص النباتي يتركيزي (50 و 100 ملغم\كغم) على التوالي. اظهرت النتائج قابلية النبات على زيادة الانقسام الخلوي بالمقارنه مع السيطرة الموجبة والسالبة كما اظهرت قابلية النبات على خفض نسبة تكون النوى الصغيرة وتحطم الدنا بالمقارنه ايضا مع السيطرتين الموجبة والسالبة.Medicinal plants or their secondary metabolites have shown different biological effects with a wide range of pharmacological properties; for instance, immune stimulator, anti-bacterial, anti-viral, anti-inflammatory, anti-oxidant, anti-mutagenic, anticancer, hepatoprotective, and many other properties. One of these medicinal plants is Ammi majus. The purpose of this research was to evaluate the cytogenetic impact of a methanolic extract of the Ammi majus plant on micronucleus formation, mitotic index and DNA damage in mice that had been given intraperitoneally mitoxantrone medicine (anticancer drug). Mice were divided into four groups, each group consisting of four mice: group I (positive control), mice treated with 0.008 mg/mouse mitoxantrone, group II (negative control), mice not given any treatment, group III, and group IV (interaction groups), mice treated with 50 mg/kg and 100 mg/kg of plant extract three through seven, respectively, after receiving injections of the mitoxantrone drug on days one and two. The findings showed that, in comparison to positive and negative controls, the plant has the ability to induce the mitotic index to 10.67±2.33% and 12.65± 3.01% for 50 and 100 mg\kg respectively, compared to 5.31±1.33% for mitoxantrone treated mice. In addition, the results of micronucleus formation indicated the capacity of the plant to reduce its formation to 2.63 ±0.011 and 2.47±0.012 micronucleus\cell after treating the mice with Ammi majus two doses (50 and 100 mg\kg), in comparison to the drug that enhances micronucleus formation to (4.28± 0.00 micronucleus\cell). DNA damage results explained the ability of the plant to reduce DNA tail damage to 134 ±22.3 and 117 ±16.1% for 50 and 100 mg/kg of Ammi majus extract, respectively which increased to (176 ±11.23%) after mice were treated with drugs. All these findings may be attributed to plant-active compounds such as flavonoids and other constituents
Therapeutic effect of rupatadine against L-arginine-induced acute pancreatitis in rats: role of inflammation
Get PDFAcute pancreatitis (AP) is an abrupt inflammatory disorder causing high morbidity and mortality. As AP is an insidious medical emergency, a curative modality is required instead of a preventive measure. Thus, we investigated the possible curative effect of rupatadine on a rat model of AP. Rupatadine is a potent histamine receptor 1 (H1R) and platelet-activating factor (PAF) blockers. We used four groups of six Wistar rats as follows: the control group received vehicle, the rupatadine control group received rupatadine 6 mg/kg orally, the AP group received L-arginine intraperitoneal, and the treatment group received rupatadine at 1, 6, and 24 h after L-arginine injection. The levels of serum amylase, pancreatic oxidative parameters, and pancreatic cytokines were measured. PAF, histamine, and myeloperoxidase levels were determined in the pancreas. Histopathological and immunohistochemical examinations were performed to determine nuclear factor kappa-B (NF-κB) and caspase 3 expressions. Oxidative damage and severe inflammation were detected in the pancreas of the AP group. Rupatadine reduced the oxidative damage and the levels of proinflammatory cytokines, PAF, histamine, and myeloperoxidase and NF-κB and caspase 3 expressions. It restored the pancreatic acini to almost the normal condition. Rupatadine induced important anti-inflammatory and antiapoptotic effects against L-arginine-induced AP.The presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author
Clinicopathologic features of hepatic neoplasms in explanted livers : A single institution experience
No full textBackground: Hepatic neoplasms can be the primary indication for hepatic transplantation. The tumors can also be incidentally identified in explanted livers. We explored the clinicopathologic features of hepatic neoplasms identified in explanted livers Materials and Methods: All explanted livers resected between 2001 and 2006 were evaluated for the presence of neoplasms and their clinicopathologic features were examined. Results: In 98 liver transplants, 15 neoplasms (15.3%) were identified. Patient ages ranged from 5 to 63 years (median, 56 years). The primary etiology of hepatic disease was hepatitis C virus in 12 cases, hepatitis B virus in 1 case, cryptogenic cirrhosis in 1 case and congenital hepatic fibrosis in 1 case. Serum alpha-fetoprotein was significantly elevated (>400 U/L) in only 2 cases. CA19-9 was not elevated in any of the cases. The tumors included hepatocellular carcinoma (HCC) in 13 cases, 1 case of cholangiocarcinoma and 1 case of combined HCC and hepatoblastoma. The tumors ranged in size from 0.5 to 5 cm (median 1.4 cm) and were multifocal in 5 of the cases (33%). Tissue alpha-fetoprotein expression was only seen in the cases associated with elevated serum levels. Conclusion: In our institution hepatic neoplasms are seen in more than 15% of explanted livers. They can be incidentally identified, are frequently not associated with elevated serum levels of alpha-fetoprotein and CA19-9, are commonly multifocal but small, and are associated with good prognosis. Elevated serum alpha-fetoprotein, albeit specific, is not a very sensitive marker in the detection of hepatic neoplasms
Clinicopathologic features of hepatic neoplasms in explanted livers: a single institution experience
No full textAdaptation and validation of a questionnaire assessing patient satisfaction with pharmacy services in general hospitals
Get PDFObjective: The aim of this study was to cross-culturally adapt the Armando Patient Satisfaction Questionnaire into Arabic and validate its use in the general population.
Methods: The translation was conducted based on the principles of the most widely used model in questionnaire translation, namely Brisling’s back-translation model. A written authorization allowing translation into Arabic was obtained from the original author. The Arabic version of the questionnaire was distributed to 480 participants to evaluate construct validity. Statistical Package for Social Sciences version 17.0 for Windows was used for the statistical analysis.
Results: The response rate of this study was 96%; most of the respondents (52.5%) were female. Internal consistency was assessed using Cronbach’s α, which showed that this questionnaire provides a high reliability coefficient (reaching 0.9299) and a high degree of consistency and thus can be relied upon in future patient satisfaction research
Protective Effects of Selenium in Tacrolimus-induced Lung Toxicity: Potential Role of Hemeoxygenase-1
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The present study aimed to evaluate the protective effects of selenium administration against tacrolimus (Tac) induced lung toxicity and to assess the relation between heme oxygenase 1 (HO-1) and these effects. The study was conducted on 36 Wistar male albino rats equally divided into 4 groups: (1) normal control, (2) Selenium (Sel 0.1mg/kg/day p.o for four weeks), (3) TAC 3mg/ml as single oral dose on 27th day (4) Tac + Sel. Lung tissues, lung homogenate, and bronchoalveolar lavage of the sacrificed animals were investigated biochemically, histopathologically, by immunohistochemistry or by PCR. Tac group showed significantly lower expression of HO-1. Administration of selenium was associated with increased HO-1 expression. Oxidative (malondialdehyde: MDA, reduced glutathione: GSH, superoxide dismutase: SOD, myeloperoxidase: MPO, glutathione peroxidase activity: GPx) and nitrosative stress (Nitric oxide: NO) markers and markers of inflammation (Interleukins: IL1β, 6 and 10) showed changes corresponding to HO-1 levels in rats groups. Tac group showed the highest expression of caspase-3. Selenium exerted protective role against tacrolimus induced lung toxicity.The presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author
The Effect of Using Computer Technology Tools to Enhance the Teaching-Learning Process in CAD-CAM-CNC Module in Mechanical Engineering Subject Area
No full textThis study presents the evaluation of Computer Assisted Learning (CAL) package included in the teaching and learning methodology of computer aided design- computer aided design - computer numerical control (CAD-CAM-CNC) module.
Three groups of students with similar pre-abilities were exposed to three different teaching learning methodologies.The effectiveness of these three methods was determined by questionnaires completed by the students and collected by first author. Their answers were analysed quantitatively and qualitatively. The various categories used in the questionnaire was student’s attitudes towards learning CAD-CAM-CNC subjects, students’ opinions about their lecturers approaches to teaching process, students’ opinions and views about various aspects the CAD-CAM-CNC. The study concludes that the students taught with a combination of CAL package and traditional methods were more effective, efficient and satisfied with their learning experiences. So the proposed hybrid learning method (CAI plus traditional teaching method) is most suited for CAD-CAM-CNC teaching.
Computer Technology; Computer-Assisted Instruction (CAI); Computer Assisted Learning (CAL); Computer Aided Design (CAD); Computer Aided Manufacturing (CAM); Computer Numerical Control (CNC)
Survival Trends in Pediatric Differentiated Thyroid Cancer: A Middle Eastern Perspective
No full textPediatric Differentiated Thyroid Cancer (pedDTC) is a rare pediatric malignancy with an increasing incidence over time. To date, there is a paucity of literature specifically addressing pedDTC within the context of Middle Eastern ethnicity. This retrospective study aimed to assess the risk-stratifying factors for overall survival (OS) and event-free survival (EFS) in pediatric DTC patients from Iraq and Jordan. The medical records of 81 patients from two tertiary cancer institutes were retrieved. Kaplan–Meier analysis was employed to investigate OS and EFS, and the Cox proportional hazards model was employed to estimate hazard ratios. All patients underwent surgery and radioactive iodine therapy, with a median age of 14 and an interquartile range of 12–15. Lymph node involvement was observed in 55% of cases, while distant metastases were present in 13.5%. After a median follow-up period of 68 months, the 10-year survival rate was determined to be 94%, while the 10-year EFS rate was 58%. EFS was negatively impacted by cervical lymph node metastases and early age of diagnosis (p ≤ 0.01, each). Therefore, pediatrics with initial cervical lymph node metastases and those diagnosed before puberty tend to experience poorer EFS, which may justify the need for more aggressive management plans
An analysis of the Concept of Freedom and its Implications for Educational Theory and Practice in Egypt, 1805-2000
Get PDFThe current study attempts to analyse the learners' right to freedom in education in order to determine the nature and content of their education. This analysis will be in relation to the philosophy of education in Egypt to improve the efficiency of the educational system. In this sense the aims of the study can be determined as follows: first to propose a theoretical framework of freedom in education in relation to its meaning, conditions, restrictions and
value, secondly, to develop this theoretical framework of education based on freedom so that it suits Egyptian society, can improve the efficiency of the educational system through the idea of freedom, and thirdly, to identify the difficulties and challenges that might
confront the claim to freedom in education in Egypt.
To achieve these aims the study contains seven chapters, an introduction, a conclusion and appendix that are necessary to achieve its aims and answer its questions. The introduction discusses the general outline of the study and the major issues, questions, aims, methodology and plan of the study. The main aim of chapter one is to analyse the concept of freedom in western and Islamic thought to build a theoretical framework of the meaning of freedom, its conditions and value, which is necessary and important to construct a theoretical framework of the meaning, conditions and value of freedom in education for
learners at school level. Chapter two aims to construct a theoretical framework of freedom in education that will depend on the analysis of the concept of freedom made in chapter one. This analysis will deal with the implications of freedom in education with respect to its conditions, restrictions and value in education. Through this analysis, chapter two aims also to analyse and examine the learners' rights to be free regarding their education. To have a
complete theoretical framework of freedom in education, chapter three discusses other implications with respect to restrictions which might limit learners' freedom by being
subject to state authority.
Chapter four investigates and analyses freedom in educational theory and practice in the history of Egypt from 1805 to 1991, whereas chapter five focuses on the period from 1992 to 2000. Following the analysis of the concept of freedom and its implications in education that will be made in the first five chapters, it would be sensible to construct a framework of educational theory based on freedom that, on one hand, should suite the Egyptian context in chapter six, on the other hand, that guarantees a range of freedom that allows learners and
society derive benefit from its value in education. Having proposed a framework of a theory of education based on freedom that suits the Egyptian context to improve the
efficiency of its educational system chapter seven will discover and examine the conditions and difficulties which need to be considered for the successful implementation of freedom in education. Also, the study will attempt to give some suggestions that might help to reduce the gap between the educational situation, its circumstances and the conditions that must be satisfied for the successful implementation of freedom in education
