15,197 research outputs found
TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation
Get PDFThe interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule binding surface. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the function of this pool, are open questions. Here, we report that TACC3 is recruited to the plus-ends of microtubules by its association with ch-TOG and that this pool is independent of phosphorylation and binding to clathrin. The plus-end binding of TACC3–ch-TOG persists in interphase and we propose that one cellular function of TACC3–ch-TOG is to modulate cell migration. We also describe the distinct subcellular pools of TACC3, ch-TOG and clathrin. TACC3 is often described as a centrosomal protein, but we show that there is no significant population of TACC3 at centrosomes. The delineation of distinct protein pools reveals a simplified view of how these proteins are organized and controlled by post-translational modification
Special Review: NMR Studies on Membrane Associated Peptides and Proteins of Influenza Virus
No full textYenan, China, Hsu Meng-ch\u27iu
No full textAn image scanned from a black and white photograph with a handwritten caption on the back that reads, Haii-Meng-ch\u27ien; writer; political commissar. The caption of the published version reads, Hsu Meng-ch\u27iu, political commissar and historian, whose legs were amputated after being frozen on the Long March. One in a series of photographs documenting a trip taken by Thomas Arthur Bisson and related to his subsequent publication, Yenan in June 1937: Talks with the Communist Leaders.https://digitalcommons.library.umaine.edu/spec_photos/3492/thumbnail.jp
Molecular modeling studies of the conserved B12-binding motif and its variants from Clostridium tetanomorphum glutamate mutase.
No full textInteractions between coenzyme B analogs and adenosylcobalamin-dependent glutamate mutase from Clostridium tetanomorphum
No full textThe protective effect of free radical scavengers and metal chelators on polyethylene glycol-treated rice leaves.
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The highly specific platelet glycoprotein (GP) VI agonist trowaglerix impaired collagen-induced platelet aggregation ex vivo through matrix metalloproteinase-dependent GPVI shedding.
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