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Low-grade inflammation may play a role in the etiology of the metabolic syndrome in patients with coronary heart disease: the HIFMECH study.
No full textCommon variants in the thrombomodulin gene as a risk for myocardial infarction in the north of Europe (HIFMECH Study).
No full textPlasma fibrinogen concentration predicts the risk of myocardial infarction differently in various parts of Europe: effects of beta-fibrinogen genotype and environmental factors. The HIFMECH Study.
No full textThe plasminogen activator inhibitor-1 -675 4G/5G genotype influences the risk of myocardial infarction associated with elevated plasma proinsulin and insulin concentrations in men from Europe: the HIFMECH study.
No full textLow-grade inflammation may play a role in the etiology of the metabolic syndrome in patients with coronary heart disease: the HIFMECH study
No full textRisk of coronary heart disease has been related to insulin resistance, but the mechanism for this is incompletely understood.
Variables attributed to insulin resistance are associated with low-grade inflammation. A case-control study was performed
of 469 male myocardial infarction (MI) survivors aged <60 years and 575 control subjects recruited from centers in northern
and southern Europe. Principal factor analysis was used to explore correlations between insulin resistance and inflammatory
variables. Three factors resulted: (a) “Metabolic Syndrome” (insulin/proinsulin/ triglyceride/body mass index [BMI]); (b)
“Inflammation” (fibrinogen/C-reactive protein [CRP]/interleukin-6 [IL-6]); and (c) “Blood Pressure” (systolic and diastolic
blood pressure). The “Metabolic Syndrome” factor was related to the “Inflammation” factor (largely independently of
obesity), the “Blood Pressure” factor, smoking, and south location (all P < .0002). There were significant relationships
between all 3 factors and case status (P < .0002). Markers of low-grade inflammation are strongly related to metabolic
syndrome variables independently of obesity. This raises the possibility that links between insulin resistance and cardiovascular
disease could, in part, represent common consequences of low-grade inflammatio
Effect of Interleukin-6 promoter polymorphisms in survivors of myocardial infarction and matched controls in the North and South of Europe. The HIFMECH Study
No full textElevated plasma IL-6 levels have been implicated in the pathogenesis of coronary heart disease. We have investigated the association of two polymorphisms in the promoter of IL-6 (-572G>C and -174G>C) with levels of inflammatory markers and risk of myocardial infarction (MI) in a European study of MI survivors and age-matched controls from two high-risk centres in the North of Europe, and two low risk centres in the South. IL-6 and CRP levels were similar in controls in both regions, but were higher in cases. For the -174G>C polymorphism the rare -174C allele showed a regional difference in allele frequency, being more common in the North European group (0.43 vs 0.28; p C in either group. Neither genotype was associated with a significant effect on plasma IL-6 levels in either cases or controls. Furthermore, no regional difference was observed in the frequency of the -572G>C SNP, suggesting that these polymorphisms are unlikely to be contributing to the observed increased risk of cardiovascular disease in Northern Europ
Plasma thrombin-activatable fibrinolysis inhibitor antigen concentration and genotype in relation to myocardial infarction in the north and south of Europe.
No full textInteraction between the C-260T polymorphism of the CD14 gene and the plasma IL-6 concentration on the risk of myocardial infarction: the HIFMECH study.
No full textEffect of Interleukin-6 promoter polymorphisms in survivors of myocardial infarction and matched controls in the North and South of Europe. The HIFMECH Study.
No full textElevated plasma IL-6 levels have been implicated in the pathogenesis of coronary heart disease. We have investigated the association of two polymorphisms in the promoter of IL-6 (-572G>C and -174G>C) with levels of inflammatory markers and risk of myocardial infarction (MI) in a European study of MI survivors and age-matched controls from two high-risk centres in the North of Europe, and two low risk centres in the South. IL-6 and CRP levels were similar in controls in both regions, but were higher in cases. For the -174G>C polymorphism the rare -174C allele showed a regional difference in allele frequency, being more common in the North European group (0.43 vs 0.28; p C in either group. Neither genotype was associated with a significant effect on plasma IL-6 levels in either cases or controls. Furthermore, no regional difference was observed in the frequency of the -572G>C SNP, suggesting that these polymorphisms are unlikely to be contributing to the observed increased risk of cardiovascular disease in Northern Europe
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