75 research outputs found
ASEAN-EU university network programme on EMC and SI education
No full textThis paper reports about a project for the creation of an innovative university course devoted to the preparation of future electronic designers to the challenges imposed by the assurance of the electrical performance of high-speed electronic systems. The target groups are future university teaching staff and future electronic systems designers. Activities are developed by means of sharing research results, seminars, experience exchange and the development of demonstrators to be used for teaching. The partnership is composed by Technical University of Turin (Italy), University of Hannover (Germany), University of Nottingham (UK), Nanyang Technological University (Singapore) and King Monguts Institute of Technology Lad-krabang, Bangkok (Thailand). The program is partially funded by the European Commission under the ASEAN-EU University Network Programme (AUNP) and its duration is 24 months
Advanced modeling of nonuniform interconnects
No full textA class of numerical schemes for the transient simulation of nonuniform interconnects loaded with arbitrary terminations is presented. The approach is based on a weak formulation of the Nonuniform Multiconductor Transmission Lines (NMTL) equations through expansion and testing with suitable basis functions sets. Depending on the choice of these basis functions, it is possible to tune the behavior of the numerical scheme to the form of the expected solution, which can be predicted a priori from the type of excitation. When the exciting pulse is a regular function, it is preferable to use high-order basis functions, leading to fast convergence to the exact solution. Instead, when the exciting pulse presents some regions of fast variations being elsewhere smooth, it is possible to design simple adaptive algorithms based on the use of wavelets as trial and test functions. Adaptivity reduces the number of operations required to compute the solution. Several examples illustrate the behavior of both high-order and adaptive scheme
Explanation of the discontinuity in the spin-relaxation time of 3A1
No full textA Comment on the Letter by S. T. Lu, Q. Jiang, and H. Kojima, Phys. Rev. Lett 62, 1639 (1989)
Black-Box Modeling of Digital Devices
No full textThe design for signal integrity and electromagnetic compatibility of modern fast electronic circuits heavily relies on numerical simulations and requires effective models of active devices. Black-box identification methods based on I/O data may offer a useful systematic approach to build such models. Black-box identification could be used for both the modeling of unknown components and for the refinement or the simplification of existing models. In this paper, we address the black-box identification of digital devices via NARX (Nonlinear AutoRegression with eXtra input) models. We apply a NARX identification algorithm to model a common highly nonlinear and fast electronic device, the CMOS inverter gate, and we perform different tests to assess the effectiveness of such an approach. We obtain accurate models with relatively simple structures and we also verify a low sensitivity of the identification process to the noise affecting the output dat
Hypocretin/orexin increases the expression of steroidogenic enzymes in human adrenocortical NCI H295R cells
No full textWenzel J, Grabinski N, Knopp CA, Dendorfer A, Ramanjaneya M, Randeva HS, Ehrhart-Bornstein M, Dominiak P, Johren O. Hypocretin/orexin increases the expression of steroidogenic enzymes in human adrenocortical NCI H295R cells. Am J Physiol Regul Integr Comp Physiol 297: R1601-R1609, 2009. First published September 30, 2009; doi: 10.1152/ajpregu. 91034.2008.-Hypocretins/orexins act through two receptor subtypes: OX1 and OX2. Outside the brain, orexin receptors are expressed in adrenal glands, where orexins stimulate the release of glucocorticoids. To further address the regulation of steroidogenesis, we analyzed the effect of orexins on the expression of steroidogenic enzymes in human adrenocortical National Cancer Institute (NCI) H295R cells by qPCR. In NCI H295R cells, OX2 receptors were highly expressed, as they were in human adrenal glands. After treatment of NCI H295R cells with orexin A for 12-24 h, the cortisol synthesis rate was significantly increased, whereas 30 min of treatment showed no effect. While CYP11B1 and CYP11B2 mRNA levels were increased already at earlier time points, the expression of HSD3B2 and CYP21 mRNA was significantly up-regulated after treatment with orexin A for 12 h. Likewise, orexin B increased CYP21 and HSD3B2 mRNA levels showing, however, a lower potency compared with orexin A. The mRNA levels of CYP11A and CYP17 were unaffected by orexin A. OX2 receptor mRNA levels were down-regulated after 12 and 24 h of orexin A treatment. Orexin A increased intracellular Ca2+ but not cAMP concentrations in NCI H295R cells. Furthermore, inhibition of PKC and MAPK kinase/ERK kinase (MEK1/2) prevented the increase of HSD3B2 expression by orexin A. Accordingly, orexin A treatment of NCI H295R cells markedly enhanced ERK1/2 phosphorylation that was prevented by PKC and, in part, PKA inhibition. In conclusion, orexins may influence adrenal steroidogenesis by differential regulation of the expression of steroidogenic enzymes involving Ca2+, as well as PKC-ERK1/2 signaling
LISIM-simulator for time domain simulation of lossy transmission line systems in a nonlinear circuit environment
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