16 research outputs found
Increased levels of soluble HLA-G molecules in Tunisian patients with chronic hepatitis B infection
No full textHepatitis B virus (HBV) infection is a global health problem. The mechanisms of immune tolerance in HBV infection are still unclear. The host immune response plays a critical role in determining the outcome of HBV infection. Human leucocyte antigen-G (HLA-G) is involved in immunotolerogenic process and infectious diseases. This study aimed to explore the implication of soluble HLA-G (sHLA-G) and its isoforms in HBV infection. Total sHLA-G (including shedding HLA-G1 and HLA-G5) was analysed by ELISA in 95 chronic HBV patients, 83 spontaneously resolvers and 100 healthy controls (HC). To explore the presence of sHLA-G dimers, we performed an immunoprecipitation and a Western blot analysis on positive samples for sHLA-G in ELISA. The serum levels of sHLA-G were significantly increased in patients with chronic HBV patients compared to spontaneously resolvers and HC (P<.0001). Interestingly, we found an increased level of sHLA-G1 in chronic HBV patients than in spontaneously resolvers and HC (P<.001). In addition, the expression of HLA-G5 seems to be higher in the sera of chronic HBV patients than spontaneously resolvers (P=.026). The analysis of HLA-G dimers showed the presence of homodimers in 93% of chronic HBV patients, 67% in spontaneously resolvers and 60% in HC. These results provide evidence that sHLA-G may have a crucial role in the outcome of HBV infection and could be proposed as a biomarker for infection outcome. Based on its tolerogenic function, HLA-G might be considered as a new promising immunotherapeutic approach to treat the chronic infection with HBV
Sarcoïdose avec arthrite chronique du genou et exposition à la silice : à propos d’un cas
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Les facteurs pronostiques du cancer broncho-pulmonaire non à petites cellules : étude prospective
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Longs survivants de cancers bronchiques non à petites cellules stades IIIB-IV : caractéristiques et facteurs pronostiques à partir d’une série prospective
No full textÉvaluation des connaissances attitudes et pratiques par rapport à la tuberculose selon les caractéristiques sociodémographiques en Tunisie
No full textFacteurs prédictifs de mauvaise qualité du sommeil chez les patients suivis pour asthme avec rhinite allergique
No full text0185: Prevalence of conventional risk factors in 44154 Tunisians patients with coronary heart disease
No full textIntroductionThe prevalence of the major conventional cardiovascular risk factors (cigarette smoking, diabetes mellitus, hypertension, and dyslipidemia) among coronary heart disease (CHD) patients in Tunisia has not been studies extensively. The aim of this study was to evaluate the frequency of cardiovascular risk factors and their association in patients hospitalised for coronary heart disease at Rabta, charles Nicolle, Habib Thameur, Military Hospitals (Tunis), Fattouma Bourguiba hospital (Monastir), Farhat Hached, and Sahloul hospitals (Sousse); Mohamed Tahar Maamouri Hospital (Nabeul); Menzel Bourguiba Hospital and Ibn El Jazzar Hospital (Kairouan) over the period 1994-1998 and during 2004.MethodsThe clinical features of 44154 patients (25635 men (58.1%) and 18519 women (41.1%) on hospital admission were analyzed.Results40.8% of the patients were hospitalized for coronary deficiency, 16.5% for valvular cardiopathy, 4.8% for cardiomiopthy, 16.9% for arrhythmia and conduction disturbance, 3.6% for essential hypertension, 2.5% for stroke and 14.9% for various pathologies.The prevalence of hypertension, diabetes, smoking, obesity and dyslipidemia was 29.9%, 30.3%, 66.9%, 11.9%, and 30.2% respectively in the men and 43.5%, 30.2%, 3.5%, 14.6%, and 27.1% respectively in women.ConclusionWith this risk factor profile Tunisia has to implement a national strategy of primary prevention and heart health promotion in addition to the efforts recently made in secondary prevention of some chronic disease such as hypertension, diabetes, and smoking
