567 research outputs found
PowerLAPIM: An application to conduct power analysis for linear and quadratic longitudinal actor-partner interdependence models in intensive longitudinal dyadic designs
No full textsponsorship: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The research presented in this article was supported by research grants from the Fund for Scientific Research-Flanders (FWO; Project No. G0C9821N) and from the Research Council of KU Leuven (C14/19/054; iBOF/21/090) awarded to E. Ceulemans. (Fund for Scientific Research-Flanders (FWO)|G0C9821N, Research Council of KU Leuven|C14/19/054, Research Council of KU Leuven|iBOF/21/090)status: Publishe
Severe myoclonic epilepsy in infancy: towards an optimal treatment
No full textSevere myoclonic epilepsy in infancy, or Dravet syndrome, is one of the catastrophic epilepsy syndromes. In the past, treatment was mainly based on valproate and phenobarbital. Recently, some of the new antiepilepsy drugs, such as topiramate and stiripentol, have been shown to be promising in the treatment of this epilepsy syndrome. The treatment regimen of 12 children with Dravet syndrome and proven mutations in the alpha subunit of the sodium channel SCN1A is reported here. Five patients on the "traditional" treatment regimen are compared with seven children on an "optimal" treatment regimen based on a combination of valproate and topiramate. With respect to the literature and our own experience, we propose guidelines for "optimal" treatment of children with severe myoclonic epilepsy in infancy. This includes prevention of hyperthermia, rigorous treatment of fever, avoiding stressful situations, maintenance treatment based on a combination of only two antiepilepsy drugs (ie, valproate and topiramate), and a strict acute seizure treatment based on benzodiazepines. To prevent long-lasting periods of status epilepticus, this acute seizure treatment must be taught to parents and caregivers
Supplemental Material - The Effect of Attachment Priming on State Attachment Security in Middle Childhood: The Moderating Roles of Trait Attachment and State Attachment Volatility
No full textSupplemental Material for The Effect of Attachment Priming on State Attachment Security in Middle Childhood: The Moderating Roles of Trait Attachment and State Attachment Volatility by B. Cuyvers, M. W. F. T. Verhees, M. H. Van IJzendoorn, M. J. Bakermans-Kranenburg, A. C. M. Rowe, E. Ceulemans, and G. Bosmans in The Journal of Early Adolescence</p
Influenza-associated encephalopathy with extensive reversible restricted diffusion within the white matter
No full textEffects of Cyclodextrin Curcumin Formulation on Ischemia-Reperfusion Injury in Porcine DCD Liver Transplantation
No full textBackground.Curcumin is a pleiotropic antioxidant polyphenol, which has proven to be highly protective in various models of liver injury and inflammation. We hypothesized that adding a stable aqueous curcumin formulation which comprises a water-soluble cyclodextrin curcumin formulation (CDC) complex of the water-insoluble curcumin molecule (Novobion, Espoo, Finland) to preservation solution during liver procurement may reduce ischemia-reperfusion injury and improve graft function after liver transplantation using donation after circulatory death (DCD). Methods.In a preclinical pig model of DCD-liver transplantation, livers exposed to 15' of warm ischemia were either modulated (N = 6) with a flush of preservation solution (histidine-tryptophan-ketoglutarate) containing CDC (60 mu mol/L) through the vena porta and the aorta, or not (controls, N = 6) before 4 h of cold storage. Area under the curve of log serum aspartate aminotransferase, markers of graft function (lactate, glycemia, prothrombin time, and bile production), inflammation (tumor necrosis factor-alpha), and survival were monitored. Results.Area under the curve of log serum aspartate aminotransferase were similar between curcumin and control groups (22.12 [20.87-24.88] versus 25.08 [22.1-26.55]; P = 0.28). No difference in the liver function markers were observed between groups except a lower serum lactate level 3-h post-reperfusion in the curcumin group (3 [1.95-6.07] versus 8.2 [4.85-13.45] mmol/L; P = 0.05). Serum tumor necrosis factor-alpha levels were similar in each group. Recipient survival rates were found similar. Conclusions.CDC added to the preservation solution in DCD liver pig model did not improve ischemia-reperfusion injury severity, liver function, or survival. Further efforts are needed to explore this strategy, particularly with dynamic preservation, which finds its way into clinical practice.This research was funded by IWT grant 100790 from the Research Foundation Flanders (Dr Monbaliu), which allowed for payment of the research nurse and research costs
Clusterwise Parafac to identify heterogeneity in three-way data
No full textIn many research areas, the Parafac model is adopted to disclose the underlying structure of three-way three-mode data. In this model, a set of latent variables, called components, that captures the complex interaction between the elements of the three modes is sought. An important assumption of this model is that these components are the same for all elements of the three modes. In many cases, however, it makes sense to assume that the components may differ (i.e., qualitative differences in underlying component structure) across groups of elements of one of the modes. Therefore, in this paper, we present Clusterwise Parafac. In this new model, the elements of one of the three modes are assigned to a limited number of mutually exclusive clusters and, simultaneously, the data within each cluster are modeled with Parafac. As such, elements that belong to the same cluster are assumed to be governed by the same components, whereas elements that are assigned to different clusters have a different underlying component structure. To evaluate the performance of the new Clusterwise Parafac strategy, an extensive simulation study is conducted. Moreover, the strategy is applied to sensory profiling data regarding different cheeses.sponsorship: The first author is a post-doctoral researcher at the Fund of Scientific Research (FWO)-Flanders. The research reported in this article was partially supported by the Fund for Scientific Research (FWO)-Flanders (Belgium), Project G.0477.09 awarded to Eva Ceulemans, Marieke Timmerman, and Patrick Onghena, and by the Research Council of KU Leuven (GOA/2010/02). (Fund for Scientific Research (FWO)-Flanders (Belgium)|G.0477.09, Research Council of KU Leuven|GOA/2010/02)status: Publishe
The exponentially weighted moving average procedure for detecting changes in intensive longitudinal data in psychological research in real-time: A tutorial showcasing potential applications
No full textAffect, behavior, and severity of psychopathological symptoms do not remain static throughout the life of an individual, but rather they change over time. Since the rise of the smartphone, longitudinal data can be obtained at higher frequencies than ever before, providing new opportunities for investigating these person-specific changes in real-time. Since 2019, researchers have started using the exponentially weighted moving average (EWMA) procedure, as a statistically sound method to reach this goal. Real-time, person-specific change detection could allow (a) researchers to adapt assessment intensity and strategy when a change occurs to obtain the most useful data at the most useful time and (b) clinicians to provide care to patients during periods in which this is most needed. The current paper provides a tutorial on how to use the EWMA procedure in psychology, as well as demonstrates its added value in a range of potential applications.sponsorship: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The research presented in this article was supported by a research grant from the Research Council of KU Leuven (C14/19/054) awarded to E. Ceulemans. (Research Council of KU Leuven|C14/19/054)status: Publishe
Combined effects of climate warming and plant diversity loss on above- and below-ground grassland productivity
No full textpeer reviewedProjections of global change predict both increases of the surface temperature and decreases of biodiversity, but studies on the combined impact of both on terrestrial ecosystems are lacking. We assessed the impact of these two global changes on above- and below-ground productivity of grassland communities. Experimental ecosystems containing one, three or nine grassland species were grown in 12 sunlit, climate-controlled chambers in Wilrijk, Belgium. Half of these chambers were exposed to ambient air temperatures, while the other half were warmed by 3 degrees C. Equal amounts of water were added to heated and unheated communities, so that any increases in evapotranspiration due to warmer conditions would result in a drier soil. Warming led to a decreased productivity of both above-ground plant parts (-18%) and roots (-23%), which coincided with a significantly lower soil water content. Complementarity in resource use and/or facilitation slightly enhanced above-ground productivity in multi-species communities, regardless of the induced warming. Interactive effects between temperature treatment and species richness level were found below-ground, however, where warming nullified the positive effect of richness on root productivity. Future warmer conditions could further increase losses of productivity associated with declining species numbers. (c) 2006 Elsevier B.V. All rights reserved.Effects of biodiversity loss and climate warming on carbon sequestration mechanisms in terrestrial ecosystem
End-of-season effects of elevated temperature on ecophysiological processes of grassland species at different species richness levels
No full textpeer reviewedThe combined effect of declining diversity and elevated temperature is a less-studied aspect of global change. We investigated the influence of those two factors and their possible interactions oil leaf ecophysiological processes in artificial grassland communities. Changes at the leaf level are at the basis of changes at the community level (and vice versa) but have remained largely unexplored in biodiversity experiments. We focused on end-of-season responses to assess whether species richness and air temperature affect the duration of the growing season. Grassland model ecosystems were used in 12 sunlit, climate-controlled chambers. Half of these chambers were exposed to ambient air temperatures, while the other half were Nvarnied 3 degrees C. Each chamber contained 24 plant communities, created with nine grassland species: three grass species. three nitrogen (N) fixers and three non-N-fixing dicots. Each plant community consisted of either one, three or nine species in order to create different species richness levels. Various ecophysiological variables (processes and characteristics) and above ground biomass were influenced by temperature. In several variables, the effects of temperature and species richness varied with species. No single-factor species richness effect was found due to opposite responses of the species canceling out the effect. We expect that these interactions may increase with time. (c) 2005 Elsevier B.V. All rights reserved
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