3,329 research outputs found
Katechetischer Leuchter und Rauchwerk
No full textdavon die Erklährung auss dem von einem Herrn Professorn der H. Schrifft zu Bern ... gestelltem, und in lateinischer Sprach aussgegebenem Catechismus-Werck ... aussgezogen, und mit hinzugesetzten schrifftmässigen Gebätten über ein jegliche Frag ... in teutscher Sprach an Tag gegeben worden von Johannes Altmann ...Der auf der Titelseite genannte Verfasser der Erklärungen ist Johann Rudolf RudolfErrata auf S. 101
Viribus unitis : Festschrift für Gabriel Altmann zum 60. Geburtstag
No full textDigitale Version der Festschrift für Gabriel Altmann zum 60. Geburtstag. Ursprünglich im Druck 1991 erschienen
Operis dialogistici prodromus, oder, Christlicher Religions-Gesprächen erster [- zweyter] Theil
No full textErster Theil Begreiffend ein Gespräch über die Frag, ob ein Prediger des Evangeliums also nohtwendig müsse widergebohren seyn, dass derjenige, welcher sich nicht als einen solchen erweisst, als ein unnützer und betrieglicher Arbeiter, von welchem der Kirchen leichtlich mehr Schaden als Nutzen zukommen könte, von heilsbegierrigen Seelen alsobald solle verlassen werden?Zweyter Theil Begreiffend etliche Gespräch eines Pfarrers, die er theils in Hauss-Besuchungen, theils bey anderen Anläsen mit einichen von seinen Zuhöreren gehalten, darinn die bey dem gemeinen Volk von dem wahren Glaubens-Grund, von dem Elend und Erlösung des Menschen, von dem ewigen Testament und den Bündtnussen Gottes, von der Gerechtsprechung, Heiligung, von dem h. Tauff und Abendmahl und von dem gemeinen Leben und Wandel deren, die sich Christen nennen, befindtlichen Vorurtheil, Irrthum und Missbräuche auf eine einfaltige und freundtliche Weis widerlegt und die fürnemsten Haubtstuck Christlicher Religion kürzlich erklährt werden.zu gemeiner Erbauung an Tag gegeben von Joh. Altmann, V.D.M.L.Impressum des 2. Teils: "In Verlegung Joh. Finssler, Buchb.
De Frigore Æstatis Et Calore Hyemis In Zona Temperata Septentrionali, h. e. Von kalten Sommern und warmen Wintern in unsern mitternächtigen Ländern ... Ad Diem XXII. Aprilis A. MDCCXI. Disputabunt Præses M. Christian Altmann, ... Et Respondens Joh. Christianus Sühnelius, Cament-Lus.
No full textDE FRIGORE ÆSTATIS ET CALORE HYEMIS IN ZONA TEMPERATA SEPTENTRIONALI, H. E. VON KALTEN SOMMERN UND WARMEN WINTERN IN UNSERN MITTERNÄCHTIGEN LÄNDERN ... AD DIEM XXII. APRILIS A. MDCCXI. DISPUTABUNT PRÆSES M. CHRISTIAN ALTMANN, ... ET RESPONDENS JOH. CHRISTIANUS SÜHNELIUS, CAMENT-LUS.
De Frigore Æstatis Et Calore Hyemis In Zona Temperata Septentrionali, h. e. Von kalten Sommern und warmen Wintern in unsern mitternächtigen Ländern ... Ad Diem XXII. Aprilis A. MDCCXI. Disputabunt Præses M. Christian Altmann, ... Et Respondens Joh. Christianus Sühnelius, Cament-Lus. (1)
Titelblatt (1)
Prooemium (3)
§. I. - X. (7)
§. XI. - XX. (12)
§. XXI. - XXV. (20
Optimization of Parameters in the Menzerath–Altmann Law, II
No full textsummary:The paper continues our studies released under the same title [Andres, J., Kubáček, L., Machalová, J., Tučková, M.: Optimization of parameters in the Menzerath–Altmann law Acta Univ. Palacki. Olomuc., Fac. rer. nat., Math. 51, 1 (2012), 5–27.]. As the main result justifying the conclusions in [Andres, J., Kubáček, L., Machalová, J., Tučková, M.: Optimization of parameters in the Menzerath–Altmann law Acta Univ. Palacki. Olomuc., Fac. rer. nat., Math. 51, 1 (2012), 5–27.], the theorem is presented enunciating that the English original of Poe’s celebrated poem Raven is a language fractal only w.r.t. the application of the simplest truncated formulas of the Menzerath–Altmann law, but not w.r.t. other applied formulas under our consideration. Moreover, the related degree of semanticity is calculated in these cases, including the naive intervals of such a degree. A suitability of the applied formulas is discussed from the point of view of a verbal version of the Menzerath–Altmann law (i.e. the tendency of the approximating functions is to be decreasing) and by means of quantitative criteria characterizing the accuracy of fitted data. Our discussion extends the traditional approaches to the Menzerath–Altmann law
Soft nanocarrier development as a versatile approach to brain delivery and targeting
No full textThe blood–brain barrier (BBB) is a selective system of endothelial cells, joined through the tight junctions, that protect and maintain the homeostasis of the Central Nervous System (CNS). Only small molecule or drugs, with high lipid solubility and a lower molecular mass under 400–500 Da, can cross the BBB in pharmacologically significant amounts, limiting the uptake of most therapeutic agents into the brain.
Currently, the management of neurological with aggressive and invasive techniques (surgery, see Appendix 3), achieves higher therapeutic effect compared to conventional delivery methods, such as systemic administration via intravenous injection or oral administration. However invasive techniques achieve less compliance.
This has led to the development of vogue treatments such as nose-to-brain technologies (see Appendix 2), FUS-induced BBB opening, fusion protein chaperones, stem cells, gene therapy, use of natural compounds and neuroprotectants, in order to increase the neuroavailability of various advanced drug delivery systems. These strategies provide promising alternatives that are able to ameliorate the treatment of brain disease.
At this purpose, several nanocarriers ranging from the more established systems, e.g. polymeric nanoparticles, liposomes, niosomes and micelles to the newer systems, e.g. nanoemulsions, micro and nano-bubbles, nanosuspensions and nanogels, have been studied for the delivery of therapeutics to CNS. Many of the proposed nanomedicines can be effectively transported across various in vitro and in vivo BBB models by endocytosis and/or transcytosis, and demonstrated early preclinical
success for the management of CNS conditions such as brain tumours, HIV encephalopathy, neurodegenerative disease and acute ischemic stroke. Future development of CNS nanomedicines need to focus on increasing their drug-trafficking performance and specificity for brain tissue using novel targeting moieties, improving their BBB permeability and reducing their neurotoxicity.
Targeted drug delivery is a means of concentrating drugs at a specific site relative to other parts of the body. It spares the rest of the body from toxic effects of the drug and it is also a potential means of improving therapeutic index.
This Ph.D. thesis focused on the study of the formulation of different nanocarriers for brain delivery
by two different administration routes: (1) Focused Ultrasound-mediated drug delivery, a technique that offer a unique non-invasive avenue to deliver drugs to the brain through transient opening of the BBB by using of ultrasound in combination with gas-filled bubbles. Our laboratory developed new carriers, the “Bubblesomes”®, able to combine the characteristics of a drug carrier and a contrast agent (theranostic system). When focused ultrasound is applied in presence of drug loaded nanobubbles intravenously administered, inertial cavitation is induced, due to the rapid expansion and violent collapsing of bubbles. This can cause the temporal and fully reversible opening of BBB due to the enhanced endothelial porosity and vascular permeability phenomenon called sonoporation, resulting in an increased drug uptake.
(2) Intranasal drug delivery, a non-invasive route to reach directly the brain, circumvent the BBB, from the nose along the olfactory and trigeminal nerve pathways. These nerve pathways initiate in the nasal cavity at olfactory neuroepithelium and terminate in the brain
Optimization of parameters in the Menzerath–Altmann law
No full textsummary:Four formulas of the Menzerath–Altmann law are tested from the point of view of their applicability and suitability. The accuracy of related approximations of measured data is examined by the least square method at first. Then the accuracy of calculated parameters in the formulas under consideration is compared statistically. The influence of neglecting parameter is investigated as well. Finally, the obtained results are discussed by means of an illustrative example from quantitative linguistics
Memoiren. [Fragment] /
No full textAltmann tells the story of the Jewish community in Nikolsburg starting in 1370. He focuses specifically on the history of the Altmann family, especially Siegfried Altmann's grandparents. The second part of the manuscript deals with stories of Rabbi Mordechai Benet (1753-1829) as told to the author by his grand-aunt.See also archival collection.Altmann was born in Nikolsburg (Maehren) in 1887 and died in 1963 in New York. He was the director of the Institute for the Blind "Hohe Warte" in Vienna.see archival collection AR 1788Benet, MordechaiWalter, BrunoNikolsburg (Moravia)digitize
Benzylchlorocarbene : kinetics parameters for 1,2-H migration, UB absorption spectrum, and mechanism for addition to alkenes
No full textPT: J; CR: ALTMANN JA, 1974, J AM CHEM SOC, V96, P4196 ALTMANN JA, 1975, J AM CHEM SOC, V97, P5217 BIRKS JB, 1970, PHOTOPHYSICS AROMATI, P303 BODAR N, 1972, J AM CHEM SOC, V94, P9103 BONNEAU R, 1989, J PHYS CHEM-US, V93, P4802 BURFIELD DR, 1981, J ORG CHEM, V46, P629 BURNETT SM, 1983, CHEM PHYS LETT, V100, P124 FRENKING G, 1984, TETRAHEDRON, V40, P2123 GOULD IR, 1985, TETRAHEDRON, V41, P1987 GRAHAM WH, 1965, J AM CHEM SOC, V87, P4396 HOUK KN, 1984, J AM CHEM SOC, V106, P4291 HOUK KN, 1984, J AM CHEM SOC, V106, P4293 JACKSON JE, 1988, J AM CHEM SOC, V110, P5595 JACKSON JE, 1989, J AM CHEM SOC, V111, P6874 KYBA EP, 1977, J AM CHEM SOC, V99, P8330 LIU MTH, 1985, J CHEM SOC CHEM COMM, P982 LIU MTH, 1986, J PHYS CHEM-US, V90, P75 LIU MTH, 1989, J CHEM SOC CHEM COMM, P12 MOSS RA, 1986, J AM CHEM SOC, V108, P7028 NOBES RH, 1980, CHEM PHYS LETT, V74, P269 RAGHAVACHARI K, 1982, CHEM PHYS LETT, V85, P145 SCHAEFER HF, 1979, ACCOUNTS CHEM RES, V12, P288 STEVENS IDR, 1989, TETRAHEDRON LETT, V30, P481 SU DTT, 1978, J AM CHEM SOC, V100, P1872 WARNER PM, 1984, TETRAHEDRON LETT, V25, P4211 WUBBELS GG, 1983, ACCOUNTS CHEM RES, V16, P285 ZUGRAVESCU I, 1976, N YLID CHEM; NR: 27; TC: 63; J9: J AMER CHEM SOC; PG: 5; GA: DC941Source type: Electronic(1
Biosensors & enzymatic fuel cells based on direct electron transfer of dehydrogenases: characterization and applications
No full textIl lavoro svolto durante i tre anni di dottorato è stato indirizzato verso lo sviluppo di nuovi metodi di sintesi ed elettrosintesi di nanomateriali metallici o carboniosi per il miglioramento del trasferimento elettronico diretto tra l’enzima e l’elettrodo. Questo miglioramento si traduce in un notevole incremento della sensibilità, stabilità e selettività dei biosensori sviluppati nonché della potenza generata da una pila enzimatica a biocombustibile, (Biofuel Cell). La prima parte della tesi riguarda lo studio e l’ottimizzazione del trasferimento elettronico diretto della cellobiosio deidrogenasi (CDH), un enzima appartenente alle flavoemeossidoreduttasi, costituito da due subunità dotate rispettivamente di cofattore FAD (subunità I) e heme b (subunità II). In questa parte abbiamo sintetizzato nanoparticelle di oro e di argento con un nuovo metodo “green”, che impiega come
agente riducente la quercetina, un noto flavonoide presente in numerosi alimenti e bevande (es. tè, capperi, mirtilli, etc.). La reazione è stata condotta a temperatura ambiente e a pressione atmosferica senza ulteriore purificazione in quanto la quercetina
è nota avere un comportamento stabilizzante delle sospensioni colloidali. Le suddette nanoparticelle sono state impiegate nella costruzione di biosensori per la determinazione del lattosio e di una pila a biocombustibile glucosio/ossigeno.
Successivamente, abbiamo sviluppato un nuovo metodo per l’elettrodeposizione di nanoparticelle di oro in modo da ottenere una superficie nanostrutturata ordinata che ha portato allo sviluppo di un biosensore per la determinazione del glucosio nella saliva.
La seconda parte della tesi riguarda lo studio del meccanismo del trasferimento elettronico diretto della fruttosio deidrogenasi (FDH), con particolare attenzione rivolta all’influenza dei cationi monovalenti e bivalenti, all’influenza della forma delle
nanoparticelle sulla catalisi enzimatica, all’individuazione dei siti “heme” coinvolti nel trasferimento elettronico diretto attraverso l’accesso ad una porzione idrofobica dell’enzima, ed infine allo sviluppo di un biosensore per la determinazione del fruttosio
realizzato immobilizzando la FDH su elettrodi di oro altamente poroso.The aim of this thesis is the study and the enhancement of the direct electron transfer of two different dehydrogenases, by means of a proper nanostructuration of the electrodes, for biosensors and enzymatic fuel cells (EFCs) development. Cellobiose dehydrogenase (CDH) is an extracellular enzyme belonging to the oxidoreductase group. CDH contains two subunits: (a) subunit I is the dehydrogenase domain (DHCDH), similar to the domain of other oxidoreductases, which belongs to the glucose-methanol-choline (GMC) oxidoreductase superfamily with a flavin adenine dinucleotide (FAD) co-factor covalently bound to the enzyme structure; (b) subunit II is the cytochrome domain (CYTCDH), which contains a heme b and acts as a built-in mediator by shuttling the electrons to a modified electrode. Both subunits are connected through a flexible linker responsible of the modulation of the internal electron transfer (IET) rate by varying the experimental conditions, such as changes of pH and divalent cations the concentration. Fructose dehydrogenase (FDH) is a membrane-bound flavocytochrome oxidoreductase which also belongs to the hemoflavoproteins family. FDH is a heterotrimeric membrane-bound enzyme complex with a molecular mass of 146.4 kDa,
consisting of three subunits: (a) subunit I (DHFDH) is the catalytic domain with a covalently bound flavin adenine dinucleotide (FAD) cofactor, where D-(-)-fructose is involved in a 2H+/2e- oxidation to 5-dehydro-D-(-)-fructose; (b) subunit II (CYTFDH) acts as a built-in electron acceptor with three heme c moieties covalently bound to the enzyme scaffold and two of them involved in the electron transfer pathway; (c) subunit III is not involved in the electron transfer but plays a key role for the enzyme complex stability.
The central target of the present thesis is the possibility to improve the electron transfer through the electrode nanostructuration, which can be realized by exploiting new nanomaterials as well as new nanostructuration methods (e.g. “green” synthesized metal nanoparticles, electrodeposition etc.). In the thesis much attention has been paid also to the understanding of the electron transfer pathway of FDH, which would be of fundamental interest in the near future for the development of highly sensitive biosensors and efficient EFCs. The biosensors realized and optimized in this thesis are prototypes of devices that, hopefully, will be commercially available on the market in the next future
- …
