171 research outputs found
Maternale Risikofaktoren bei Intrauterinem Fruchttod – eine Retrospektive Single Center Analyse über 18 Jahre
No full textToni Kitanovski, performance at MC Gallery, New York, USA
Get PDFToni Kitanovski performed supported by DJ Goce providing soundscape at the oppening of an exibition of Simonida Filipova Kitanovska at MC Gallery in New Yourk City
Endogenous Information and Privacy in Automobile Insurance Markets
Get PDFThis paper examines the implications of insurers’ offering a voluntary monitoring technology to insureds in automobile insurance markets with adverse selection and without commitment. Under the consideration of the inherent costs related to the loss of privacy, the paper analyzes the incentives of insureds to reveal information, whereby they can decide how much or what quality of information to reveal. It is also allowed for the possibility that high risk individuals might mimic low risk individuals. The resulting market equilibrium is characterized and it is shown, that it will never be optimal for insureds to reject the monitoring technology and that under certain conditions, which are specified in the paper, it will be optimal for them to reveal complete information. Concerning the welfare effects both low risk and high risk individuals will always be better off. Unless it is optimal for individuals to reveal complete information, an all-or-nothing nature of the monitoring technology will not be efficient.adverse selection, privacy, insurance, risk classification, endogenous information acquisition
Endogenous Information and Privacy in Automobile Insurance Markets
Get PDFThis paper examines the implications of insurers’ offering a voluntary monitoring technology to insureds in automobile insurance markets with adverse selection and without commitment. Under the consideration of the inherent costs related to the loss of privacy, the paper analyzes the incentives of insureds to reveal information, whereby they can decide how much or what quality of information to reveal. It is also allowed for the possibility that high risk individuals might mimic low risk individuals. The resulting market equilibria are characterized and it is shown, that it might be optimal for insureds to reject the monitoring technology, but also that under certain conditions, which are specified in the paper, it might be optimal for insureds to reveal complete information. Concerning the welfare effects of introducing voluntary monitoring of insureds, if low risk individuals reject it, there will be no change to either risk type. If they accept it, this will make them better off and high risks may either be made better off or worse off depending on the initial equilibrium before a monitoring technology is offered. Unless it is optimal for individuals to reveal either zero or complete information, an all-or-nothing nature of the monitoring technology will not be efficient.adverse selection, privacy, insurance, risk classification, endogenous information acquisition
Junctional trafficking and restoration of retrograde signaling by the cytoplasmic RyR1 domain
No full textThe type 1 ryanodine receptor (RyR1) in skeletal muscle is a homotetrameric protein that releases Ca2+ from the sarcoplasmic reticulum (SR) in response to an “orthograde” signal from the dihydropyridine receptor (DHPR) in the plasma membrane (PM). Additionally, a “retrograde” signal from RyR1 increases the amplitude of the Ca2+ current produced by CaV1.1, the principle subunit of the DHPR. This bidirectional signaling is thought to depend on physical links, of unknown identity, between the DHPR and RyR1. Here, we investigate whether the isolated cytoplasmic domain of RyR1 can interact structurally or functionally with CaV1.1 by producing an N-terminal construct (RyR11:4300) that lacks the C-terminal membrane domain. In CaV1.1-null (dysgenic) myotubes, RyR11:4300 is diffusely distributed, but in RyR1-null (dyspedic) myotubes it localizes in puncta at SR–PM junctions containing endogenous CaV1.1. Fluorescence recovery after photobleaching indicates that diffuse RyR11:4300 is mobile, whereas resistance to being washed out with a large-bore micropipette indicates that the punctate RyR11:4300 stably associates with PM–SR junctions. Strikingly, expression of RyR11:4300 in dyspedic myotubes causes an increased amplitude, and slowed activation, of Ca2+ current through CaV1.1, which is almost identical to the effects of full-length RyR1. Fast protein liquid chromatography indicates that ∼25% of RyR11:4300 in diluted cytosolic lysate of transfected tsA201 cells is present in complexes larger in size than the monomer, and intermolecular fluorescence resonance energy transfer implies that RyR11:4300 is significantly oligomerized within intact tsA201 cells and dyspedic myotubes. A large fraction of these oligomers may be homotetramers because freeze-fracture electron micrographs reveal that the frequency of particles arranged like DHPR tetrads is substantially increased by transfecting RyR-null myotubes with RyR11:4300. In summary, the RyR1 cytoplasmic domain, separated from its SR membrane anchor, retains a tendency toward oligomerization/tetramerization, binds to SR–PM junctions in myotubes only if CaV1.1 is also present and is fully functional in retrograde signaling to CaV1.1.</jats:p
Mathematical modeling of the heat transfer during pyrolysis process used for end-of-life tires treatment
No full textVETERANS SUPPORT SERVICES AND PROGRAMS IN WISCONSIN'S PUBLIC COLLEGES AND UNIVERSITIES
Get PDFA Field Project Submitted In Partial Fulfillment.of the Requirements For the Degree of
Master of Public Administration Health Car
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