9 research outputs found
Synthesis of Highly Substituted 2,3-Dihydro-1<i>H</i>-pyrrole Derivatives via a Tandem Regioselective Addition of Nitrones to 1,3-Enynes with Subsequent Rearrangement
No full textA novel method for the synthesis of 1,3-enynes is described through oxidative cyclization of the
semicarbazones of Michael adducts having potential nitrile functionality. Reaction of these 1,3-enynes
with diaryl nitrones has yielded a diastereomeric mixture of highly substituted 2,3-dihydro-1H-pyrrole
derivatives via a tandem regioselective addition with subsequent rearrangement
One-Pot Multicomponent Solvent-Free Synthesis of 2‑Amino‑4<i>H</i>‑benzo[<i>b</i>]pyrans Catalyzed by Per-6-amino-β-cyclodextrin
No full textAn efficient three-component reaction of aromatic aldehyde,
1,3-cyclohexanedione/dimedone,
and malononitrile was developed, for the first time, using per-6-amino-β-cyclodextrin,
as a supramolecular host for aldehydes and an efficient base catalyst,
which produced various substituted 2-amino-4H-benzo[b]pyrans in good to excellent yields, under solvent-free
conditions. The catalyst can be reused at least three times without
any marked change in its catalytic activity. Other remarkable features
include a much milder procedure, a shorter reaction time, a wide range
of functional group tolerance, and absence of any tedious workup or
purification. This procedure also avoids hazardous reagents/solvents
and is thus an eco-friendly alternative to the existing methods
Synthesis of Highly Substituted 2,3-Dihydro-1<i>H</i>-pyrrole Derivatives via a Tandem Regioselective Addition of Nitrones to 1,3-Enynes with Subsequent Rearrangement
No full textA novel method for the synthesis of 1,3-enynes is described through oxidative cyclization of the
semicarbazones of Michael adducts having potential nitrile functionality. Reaction of these 1,3-enynes
with diaryl nitrones has yielded a diastereomeric mixture of highly substituted 2,3-dihydro-1H-pyrrole
derivatives via a tandem regioselective addition with subsequent rearrangement
Synthesis of Highly Substituted 2,3-Dihydro-1<i>H</i>-pyrrole Derivatives via a Tandem Regioselective Addition of Nitrones to 1,3-Enynes with Subsequent Rearrangement
No full textA novel method for the synthesis of 1,3-enynes is described through oxidative cyclization of the
semicarbazones of Michael adducts having potential nitrile functionality. Reaction of these 1,3-enynes
with diaryl nitrones has yielded a diastereomeric mixture of highly substituted 2,3-dihydro-1H-pyrrole
derivatives via a tandem regioselective addition with subsequent rearrangement
Azathioprine in inflammatory bowel disease, a safe alternative?
No full textAZATHIOPRINE an d its m e tabo lite 6-m er cap to p urin e ar e effe ctive in th e tr eatm en t of in flam m ator y bo w e l dis e as e . Th ey ar e m os tly us ed for re duction o f th e use of s ter oids , m ain ten an ce th e rap y after r e m is s ion in duction by cyclos p or in an d tr eatm e nt o f fis tulae in Cro h n 's dis eas e. Adve rs e effe cts occur in abo ut 15% of p atie nts . Th e m ain s ide effe cts ar e p an cr eatitis , alle rgic re actio ns , fe v er an d bo ne m arro w s upp r ess ion . Sy m p tom s , m anage m e nt and p r eve ntion are dis cus s ed. A blood m o nitor in g s ch e dule is s ugge s ted. Azath io pr in e an d 6-m er cap top ur in e s eem to be s afe in p r egn an cy. Th er e m ay be a s ligh t in cr e as ed r is k fo r de velopin g a n on -Ho dgkin 's lym p h om a
Smart Village: Solar Based Smart Agriculture with IoT Enabled for Climatic Change and Fertilization of Soil
No full textReport on consumer acceptability tests of NARITA hybrids in Tanzania and Uganda
No full textConsumer acceptability tests of NARITA hybrids were conducted with a total of 572 randomly selected men and women farmers from 5 sites in different agro-ecological zones in Tanzania and Uganda (Maruku, Mitalula and Moshi in Tanzania; Kawanda and Mbarara in Uganda). Evaluations were done between July and November 2018 under the project ‘Improvement of banana for smallholder farmers in the Great Lakes Region of Africa’. At each site, focus group discussions (FGDs) were first conducted with different age groups: young women, young men (35 years) to ascertain the main products households make using cooking banana cultivars and the preparation method. The most important product was then prepared in each site - steamed matooke in both Uganda sites and boiled fingers in all Tanzania sites. On a given day, about 100 farmers were each provided with coded samples of four NARITA hybrids plus one local check and asked to rate each sample on a 5-point hedonic scale for the following attributes: colour, aroma, texture in hand, taste, mouthfeel and overall acceptability. This report provides results that can help inform the selection of the best NARITAs to take on-farm and subsequent varietal release
Evolutionary trust model to achieve emergent cooperation in ad-hoc networks through genetic algorithms
No full textilustraciones, gráficas, tablasEn esta tesis, se propone un modelo evolutivo para interacciones de agentes en redes ad-hoc. Para esto, primero se hizo una revisión general sobre los diferentes tipos de modelos existentes en la literatura, con el fin de elegir un modelo en función de su pertinencia. El modelo escogido utiliza algoritmos genéticos complementados con juegos estocásticos, que se espera que ofrezcan un comportamiento adaptativo y dinámico. A continuación, se diseñaron las simulaciones con el fin de involucrar la naturaleza de las redes ad-hoc, donde se demostró que los algoritmos genéticos son capaces de adaptarse a la red, pero el proceso toma 1.000 interacciones para alcanzar indicadores favorables. En consecuencia, se propuso la inclusión de juegos estocásticos, los cuales alcanzan los mismos indicadores con solo 250 interacciones. Este resultado evidencia las ventajas del modelo propuesto. Finalmente, se realizó la implementación de una prueba piloto sobre una red ad-hoc real, validando el comportamiento de las simulaciones. La principal contribución de este trabajo es el modelo adaptativo, que además presenta una mejora en la velocidad de adaptación en entornos adversos en comparación con trabajos encontrados en la literatura. (Texto tomado de la fuente).This thesis proposes an evolutional model for agent interactions in ad-hoc networks. For this purpose, an overview is presented of the different types of existing models in the literature, in order to choose a model based on its relevance to the objective. The choosen model uses genetic algorithms improved by including stochastic games that are expected to offer an adaptative and dynamic behavior. After defining the model to be studied, the simulations were designed to involve the nature of ad-hoc networks. The simulations show that the genetic algorithms are able to adapt to the network, but the process takes 1.000 interactions to reach favorable indicators. In consecuence, the inclusion of stochastic games is proposed. With this improvement, the algorithm reaches the same indicators with only 250 interactions. This result evidences the advantages of the model proposed. Finally, the implementation in a real ad-hoc network showed results that validate the behavior observed in the simulations. The main contribution of this work is the adaptative model that also presents an improvement in the velocity of adaptation in adverse environments in comparison with previous works in the literature.Esta tesis de maestría se sustentó el 15 de Septiembre de 2021 a las 10:00 am, y fue evaluada por los siguientes jurados:
Luis Fernando Niño Vásquez (Ph.D.) Universidad Nacional de Colombia Departamento de ingeniería de sistemas e industrial
Jeisson Andrés Vergara Vargas (Ph.D.) Universidad Nacional de Colombia Departamento de ingeniería de sistemas e industrialMaestríaMagíster en Ingeniería - Ingeniería de Sistemas y ComputaciónSimulación basada en agentesComputación aplicadaTesis presentada como requisito parcial para optar al título de:
Magister en Ingeniería de Sistemas y ComputaciónDepartamento de Ingeniería de Sistemas e Industria
