1,721,157 research outputs found
Plasticity of the visual system after congenital brain damage: A few weeks can matter
No full textThis article is a commentary on Jacobson et al., pp e184–e187 of this issue
Plasticity following early-life brain injury: Insights from quantitative MRI
No full textOver the last decade, the application of novel advanced neuroimaging techniques to study congenital brain damage has provided invaluable insights into the mechanisms underlying early neuroplasticity. The concept that is clearly emerging, both from human and nun-human studies, is that functional reorganization in the immature brain is substantially different from that of the more mature, developed brain. This applies to the reorganization of language, the sensorimotor system, and the visual system. The rapid implementation and development of higher order imaging methods will offer increased, currently unavailable knowledge about the specific mechanisms of cerebral plasticity in infancy, which is essential to support the development of early therapeutic interventions aimed at supporting and enhancing functional reorganization during a time of greatest potential brain plasticity
Paediatric arterial ischaemic stroke and cerebral sinovenous thrombosis: First report from the italian registry of pediatric thrombosis (R. I. T. I., Registro Italiano Trombosi Infantili)
No full textData from large case series of children with cerebral thrombotic events are pivotal to improve prevention, early recognition and treatment of these conditions. The Italian Registry of Pediatric Thrombosis (R. I. T. I.) was established in 2007 by a multidisciplinary team, aiming for a better understanding of neonatal and paediatric thrombotic events in Italy and providing a preliminary source of data for the future development of specific clinical trials and diagnostic-therapeutic protocols. We analysed data relative to the paediatric cerebral thrombotic events of the R. I. T. I. which occurred between January 2007 and June 2012. In the study period, 79 arterial ischaemic stroke (AIS) events (49 in males) and 91 cerebral sinovenous thrombosis (CSVT) events (65 in males) were enrolled in the R. I. T. I. Mean age at onset was 4.5 years in AIS, and 7.1 years in CSVT. Most common modes of presentation were hemiparesis, seizures and speech disturbances in AIS, and headache, seizures and lethargy in CSVT. Most common etiologies were underlying chronic diseases, vasculopathy and cardiopathy in AIS, and underlying chronic diseases and infection in CSVT. Time to diagnosis exceeded 24 hours in 46% AIS and 59% CSVT. Overall data from the Italian Registry are in substantial agreement with those from the literature, despite small differences. Among these, a longer time to diagnosis compared to other registries and case series poses the accent to the need of an earlier recognition of paediatric cerebrovascular events in Italy, in order to enable prompt and effective treatment strategies
Disturbi motori e disturbi neuropsicologici: modelli fisiopatologici e strategie di trattamento
No full text
The spectrum of visual disorders in children with perinatal brain lesions: long term effects
No full text[Role of neurologic assessment in the evaluation and prognosis of full-term newborns with asphyxia].
No full textHypoxic-ischaemic encephalopathy, the clinical neurological syndrome that follows birth asphyxia, is one of the main causes of neurological sequelae in term newborns. Despite the advent of new imaging and neurophysiological techniques in the last two decades, the value of the neurological assessment of the newborn has not been reduced. The possibility to perform easily serial neurological evaluations allows a detailed and non-invasive follow up of the early developmental processes, providing reliable prognostic information. In this paper we report our experience and a more general review of the literature on the prognostic value of the neurological assessment in term newborns with hypoxic-ischaemic encephalopathy
- …
