205,567 research outputs found
003. Dress owned by Guy R. Olson of Mount Pleasant, Utah
No full textDocument for a dress owned by Guy R. Olson of Mount Pleasant, Utah. Worn by his great-grandmother, a Mrs. Harvey. Photograph not on fil
248. Missionary frock coat owned by Guy R. Olson of Mount Pleasant, Utah
No full textPhotograph of and document for a frock coat owned by Guy R. Olson of Mount Pleasant, Utah. Worn by owner\u27s father, William Olson, while on a mission to Swede
The best friends to you
No full textGift of Dr. Mary Jane Esplen.The best friends to you : dedicated to my daughters, May and Lilian ; sung by Harry Prince, lyric tenor ; true words of home set to music ; written and composed by George R. Guy ; proprieter and manager of Guy Brothers Minstrels [note]Piano vocal [instrumentation]I am thinking tonight of friends [first line]Goodbye, goodbye [first line of chorus]G [key]Moderato [tempo]Popular song [form/genre]Decorative ; Harry Prince (photograph) [illustration]Publisher's advertisement on inside back and back cover [note
246. Barndoor pants owned by Guy R. Olson of Mount Pleasant, Utah
No full textDocument for a pair of barndoor pants owned by Guy R. Olson of Mount Pleasant, Utah. Made in Virginia by owner\u27s great-grandmother, a Mrs. Harvey. Brought by her daughter, a Mrs. Tidwell, from Virginia to Utah. Photograph not in fil
Howard R. Driggs, Milton Bennion, Adam Bennion, Guy C. Wilson
No full textHoward R. Driggs, Milton Bennion, Adam Bennion, Guy C. Wilson, outside Newell Whitney's store in Kirtland, Ohio.Photograph
Howard R. Driggs, Milton Bennion, Adam Bennion, Guy C. Wilson
No full textHoward R. Driggs, Milton Bennion, Adam Bennion, Guy C. Wilson on a sleigh ride in Kirtland, Ohio.Photograph
Guy, Ray
No full textThe papers detail the literary activities of Ray Guy, one of Newfoundland's most prolific writers, satirists, and political critics; particularly his columns for The Evening Telegram and other local publications. They provide a survey of the provincial public and political issues that demanded attention and commentary over the years, such as resettlement, industrialization, and the political antics of Joseph R. Smallwood. There are also drafts of plays and sketches written by Guy while engaged in performing arts and theatrical activities. Other materials such as correspondence with fellow writers and questionnaires done by readers reveal where Guy found many of his topics. Also found within the collection are contracts with various publishing houses in the St. John's, providing a glimpse at the financial aspect of literary work, especially publishing. This collection documents the career of one of Newfoundland and Labrador's most prolific literary figures; and records public opinion and debate surrounding some of the province's most significant people and events
Spectacular Developments: Guy Debord's Parapolitical Turn
No full textFollowing the attacks of September 11th, 2001, Guy Debord’s concept of ‘the
spectacle’ re-emerged in the work of a variety of theorists as a critical prism through
which the attacks and subsequent ‘War on Terror’ could be approached. Debord’s
first book on the spectacle (1967) was written in the context of France’s post-war
boom; his later reflections, contained in a series of minor works written throughout
the seventies and eighties, are heavily influenced by Italy’s ‘Years of Lead’ and a
broader geopolitical climate of armed struggle, terrorism, counter-insurgency and
espionage. Nearly all post-9/11 invocations of Debord’s concept draw on the version
elucidated in Debord’s 1967 book, with its emphasis on commodity fetishism,
ideology, and alienation, and fail to engage his later work and its focus on terrorism,
secrecy, and conspiracy. Among those that do in fact reference Debord’s later work
are several writers whose work could pejoratively be labelled ‘conspiracy theory’.
Looking at Debord’s oeuvre as whole, and investigating how it combines a critique of
late capitalism in its totality with parapolitcal concerns of ‘systemic clandestinity’,
Spectacular Developments: Guy Debord’s Parapolitical Turn provides a bolstered
conception of the spectacle that aims to reconfigure the conceptual foundations of this
debate. This conception of the spectacle allows one to approach the 9/11 attacks and
all that followed in their wake with both a precision and a breadth lacking in these
other works, demonstrating the superficiality of readings that make the concept
synonymous with the mass media or that attempt to unravel nefarious conspiracies of
power. Simultaneously, this approach foregrounds the epistemological and strategic
challenges faced by researchers, politicians and activists working in and on the
society of the spectacle
The discovery of SycO reveals a new function for type three secretion effector chaperones
Get PDFThe Type Three Secretion (T3S) system is a device used by many Gram-negative pathogens that allows bacteria to deliver effector proteins straight into the eukaryotic cell cytosol. These effectors interfere with various signaling pathways to subvert the host cell functions. The secretion machinery of the T3S system consist of a basal body spanning the bacterial inner and outer membrane followed by a stiff hollow needle outside the bacterium. The fully assembled secretion apparatus constitute a continuous hollow conduit that connects the bacteria to the eukaryotic target cell. After cell contact, virulence proteins -called effectors- are injected directly into the cytosol of the host cell via the T3S apparatus. Several effectors of the T3S system require the assistance of specific cytosolic chaperones to be efficiently exported. There are three classes of T3S chaperones. Effector proteins are assisted by Class I chaperones. Although Class I chaperones are well characterized, their main function is still a matter of controversy. In this thesis, we demonstrate that orf155 encodes a specific chaperone for the effector YopO that we called SycO. We showed that SycO enhances YopO secretion in vitro and is required for translocation of YopO into infected cells. By pulldown assay we demonstrated that residues 20 to 77 of YopO are required and sufficient for SycO binding. Using crosslinking experiments and size exclusion chromatography analysis, we determined the stoichiometry of purified SycO and YopO-SycO complexes. SycO alone forms dimers in solution and the YopO-SycO complex has a 1:2 stoichiometry. These results suggested that SycO is a typical chaperone of the Class I. YopO is a serine/theronine kinase that interacts with Rho and Rac and disrupts the cytoskeleton of the target cells. YopO has been shown to localize at the cell plasma-membrane. By transfection of YopO-EGFP hybrid proteins into HEK293T cells, we demonstrated that the chaperone-binding domain (CBD) coincides with the membrane localization domain of YopO. Nevertheless, the CBD was not needed for the kinase activity of YopO. By ultracentrifugation, we also showed that the CBD causes YopO aggregation in the bacteria, when SycO does not cover it. Further, we show that the CBD of YopE and YopT also caused aggregation in the bacteria in the absence of SycE and SycT respectively. YopE, YopT and T3S effectors in other systems also act at the membrane of the eukaryotic host cell. We propose a new hypothesis concerning the role of T3S chaperones. The sub-cellular localization domain of effectors is aggregation-prone and creates the need for a chaperone inside bacteria. We propose that masking such aggregation-prone localization domains may be a general function for type III effector chaperones
Première caresse : polka mazurka pour piano / par Guy d'Arlande ; [couv. ornée par] R. Ferrières
No full textTitre uniforme : Arlande, Guy d' (18..-19..). Compositeur. [Première caresse. Piano]Polkas-mazurkas (piano) -- +* 1800......- 1899......+:19e siècle:Piano, Musique de -- +* 1800......- 1899......+:19e siècle
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