593 research outputs found
DREAMS AND REALITY OF THE ACADEMICIAN I.G. KALINENKO IN CREATION OF DURUM WINTER WHEAT
No full textThe article gives the analysis of 40-years selection activity of the academician I.G. Kalinenko in creation of the own initial material and the varieties of turgid and durum wheat which was new for the conditions of the Rostov region. The author gives characteristics of the initial material and the varieties on productivity, adaptability and other economic-valuable traits and properties in different period of I.G. Kalinenko work. His methods of work, initial material, a number of cycles of hybridization while creation of the varieties ‘Novinka’, ‘Novinka 2’, ‘Novinka 3’, ‘Novinka 4’, ‘Donskoy Yantar’ and other have been shown in the article. The author determines the principle role of step (gradual) hybridization to combine the desired traits and properties in the single genotype with the use of the varieties and intermediate forms of own selection, obtained in the creation of such varieties as ‘Aksinit’, ‘Kurant’, ‘Agat Donskoy’, ‘lazurit’, ‘Kristella’, ‘Oniks’. Their potential productivity is 8-10 t/ha, as the productivity of the best varieties of soft winter wheat, which the scientist, talented researcher, academician I.G. Kalinenko hoped to receive, starting breeding of durum winter wheat in 1961
Is human growth hormone an ergogenic aid?
No full textGrowth hormone (GH) was first isolated from the pituitary gland in the 1940s. It is believed that athletes have been abusing GH for its anabolic and lipolytic effects since the early 1980s, at least a decade before endocrinologists began to treat adults with GH deficiency. Most of our knowledge about GH abuse is anecdotal but a number of high-profile athletes have admitted using GH. Despite its widespread abuse, there is debate about whether GH is ergogenic. Indeed most scientific studies have not shown a performance enhancing effect. This review will address why this discrepancy of opinion between athletes and scientists exists and why the author believes that the scientists are wrong.<br/
On the masses and evolutionary status of the black hole binary GX 339-4: a twin system of XTE J1550-564?
No full textWe apply the K-correction to the black hole low-mass X-ray binary (LMXB) GX 339-4 which implies MX? 6 M? by only assuming that the companion is more massive than ?0.17 M?, the lower limit allowed by applying a ‘stripped-giant’ model. This evolutionary model successfully reproduces the observed properties of the system. We obtain a maximum mass for the companion of M2? 1.1 M? and an upper limit to the mass ratio of q(=M2/MX) ? 0.125. The high X-ray activity displayed by the source suggests a relatively large mass transfer rate which, according to the model, results in M2? 0.3 M? and MX? 7 M?. We have also applied this scenario to the black hole binary XTE J1550-564, which has a similar orbital period but the donor is detected spectroscopically. The model successfully reproduces the observed stellar parameter
Deciphering the mechanism of action of 089, a compound impairing the fungal cell cycle
No full textFungal infections represent an increasingly relevant clinical problem, primarily because of the increased survival of severely immune-compromised patients. Despite the availability of active and selective drugs and of well-established prophylaxis, classical antifungals are often ineffective as resistance is frequently observed. The quest for anti-fungal drugs with novel mechanisms of action is thus important. Here we show that a new compound, 089, acts by arresting fungal cells in the G2 phase of the cell cycle through targeting of SWE1, a mechanism of action unexploited by current anti-fungal drugs. The cell cycle impairment also induces a modification of fungal cell morphology which makes fungal cells recognizable by immune cells. This new class of molecules holds promise to be a valuable source of novel antifungals, allowing the clearance of pathogenic fungi by both direct killing of the fungus and enhancing the recognition of the pathogen by the host immune system
Comparative genomics of natural fertile hybrids of Saccharomyces cerevisiae, Saccharomyces bayanus and Saccharomyces paradoxus
No full textNatural inter-species hybrids of the genus Saccharomyces have been documented, and in some cases the
hybridization gave origin to commercially useful strains. The most renowned example is that of Saccharomyces
pastorianus, generated by the mating of S. cerevisiae and S. eubayanus, and widely used for pale ale beer
production [1]. Other natural interspecies hybrids have been more rarely documented, probably because the low
viability of their offspring strongly impact on the survival of the strain type when environmental changes are
detrimentals. While natural S. cerevisiaexS. bayanus hybrids have been found, hybrids of S. cerevisiae and S.
paradoxus are much more rare, as indicated by the few documented isolations [2], possibly because both the
different habitat and the fact that their progeny is usually not fertile. We isolated a S. cerevisiaeS. bayanus
hybrid and a S. cerevisiaeS. paradoxus hybrid from the intestine of the hornet Vespa crabro giving spores
showing 100% viability and we fully sequenced the genome of each of the four meiotic segregants after
sporulation. Using available compete and draft genome sequences of S. cerevisiae, S. bayanus and S. paradoxus
as reference, we tested whether the two parental genomes are still physically separated after the mating by
comparative genomics analysi
Review of Dwelling in the World: Family, House, and Home in Tianjin, China, 1860–1960, by Elizabeth LaCouture
No full textGreen Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care. Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Situated Architectur
From prototype SU(5) to realistic SU(7) SUSY GUT
No full textWe construct a realistic SU(7) model which provides answers to many questions presently facing the prototype SU(5) SUSY GUT. Among them are a solution to the doublet-triplet splitting problem, string scale unification, proton decay, the hierarchy of baryon vs. lepton number violation and neutrino masses
Characterization of fecal mycobiota reveals yeast-host coevolution in pediatric Crohn’s disease
No full textAt variance with the well-recognized role of intestinal bacterial communities, the fungal contribution on the balance between health and disease is still debated. Here we report that gut mycobiota of 93 healthy and Inflammatory Bowel Disease (IBD) affected children is enriched in non-pathogenic species, including Ascomycetes. Notably, phylogenetic analysis of Saccharomyces cerevisiae fecal isolates provided evidence for co-evolution of strains gut-specific with the host, clustering separately with respect to S. cerevisiae isolated worldwide from different sources. Through cytokine production, S. cerevisiae isolates differently contribute to local immune homeostasis. Whole genome sequencing of 21 fecal strains discovered wild-domestic mosaic populations evolved in the human gut, unveiling selection in specific loci regulating sporulation and pseudohypal formation as responsible for the strains’ immunomodulatory properties. Also we show that the definition of pathogenic species should be reassessed investigating the variability of the pathogenic profiles of specific strains, corroborating the idea that depending on the genetic makeup of the host and of the yeast, even S. cerevisiae could be seen as an opportunistic pathogen
Genotyping single-nucleotide polymorphisms by matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry
No full textIn recent years matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI) has emerged as a very powerful method for genotyping single nucleotide polymorphisms. The accuracy, speed of data accumulation, and data structure are the major features of MALDI. Several SNP genotyping methods have been implemented with a high degree of automation and are being applied for large-scale association studies. Most methods for SNP genotyping using MALDI mass spectrometric detection and their potential application for high-throughput are reviewed here
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