56 research outputs found
Nihâya al-Kifâya li-al-Dirâya al-Hidâya by Tâj al-Sharia Omar b. Ahmad al-Mahbûbî of the subjects between the chapter Aymân and Vaqf sections (The edition and critique)
No full textBu çalışmada, Hanefî Fakihlerden İmam Tâcüşşerîa Ömer b. Ahmed el-Mahbûbî'nin ?Nihâyetü'l-kifâye li-dirâyeti'l-Hidâye isimli eseri tahkik edilip incelenmiştir. Söz konusu ?eser, el-Hidâye'nin en eski ikinci şerhi olup Mergînânî'nin "el-Hidâye şerhu bidâyeti'l-?mübtedî" adlı eserinin "Kavlühû" tarzında bir şerhidir. Eserin, Buhâra şehri ilim ve ?siyasetinde ön plana çıkan Orta Asya Sadrüddinzâde Mahbûbî Hanefî fukahâ ailesi ?hakkında bazı bilinmeyen bilgileri de içermesi yönüyle tahkiki önem kazanmaktadır. ? Dünya kütüphanelerinde tespit edebildiğimiz kadarıyla 30 civarında farklı nüshası olup ?Türkiye kütüphanelerinde 29 farklı nüshası vardır. Konumuza dahil olan kısımlar, birinci ?cildin Türkiye Kütüphanelerindeki 14 nüshasından 5 tanesiyle karşılaştırılarak tahkik ?edilmiştir. Asıl nüshamız 713/1313 istinsah tarihli Türkiye'deki en eski ikinci nüsha olan ?İzmir Milli Kütüphanesi nüshası olup müstensihi Muhammed b. Ebî Abdillâh Yahya b. ?Muhammed el-Hamâdî'dir. O, Feyzullah Efendi, Edirne Serez ve Ragıp Paşa ?kütüphanelerindeki nüshaları da istinsah etmiştir. ? Tacüşşerîa, açık bir üslupla yazdığı eserinde el-Hidâye'den kavlühû diye zikrederek aldığı ?bazı kapalı cümleleri, ayrıntılı olarak şerh etmiştir. Hanefî mezhebinin kendinden önceki, ?kendi çağındaki ve bazen delilleriyle vardığı tercihlerini "ve aleyhi'l-fetva/fetva onun ?üzerinedir", "ve bihi yüftâ/onunla fetva verilir", "ve bihi ne'huzu/biz onu alırız", "ve ?aleyhi'l-i'timad/ona itimad edilir" vb. ibarelerle ifade etmiştir. ? Çalışmamızda dipnotlarda; müellifin metinde zikrettiği âyet ve hadislerin tahrîci yapılmış, ?zikredilen yer, şahıs, kişi isimleri ve şiirler hakkında bilgi verilerek ekte indeks olarak da ?verilmiştir. Dirâse/tanıtım-değerlendirme kısmında İSNAD atıf kuralları, İSAM tahkikli ?neşir kılavuzu esasları kullanılmıştır. ?In this study, one of the Hanafi Faqihs, Imam Taj al-Sharia Omar b. Ahmad al-Mahbûbî's ?work named Nihâya al-kifâya li-dirâya al-Hidâya was examined and edition and critique ?have been made. The work is the second oldest commentary of al-Hidaya and is a ?commentary in the style of "Qavluhû" of Marginânî's work called "al-Hidâya sharh bidâya ?al-mubtadî". The edition and critique work gains importance in terms of containing some ?unknown information about the Central Asian Sadr al-dîn zâdah Mahbubî Hanafi fuqaha ?family, which came to the fore in the science and politics of the city of Bukhara. ? As far as we can determine, there are around 30 different copies in the libraries of the world ?and there are 29 different copies in the libraries of Turkey. It was examined by comparing it ?with 5 of the 14 copies in the Turkish Libraries. Our original copy is the copy of the Izmir ?National Library, which is the second oldest copy in Turkey, dated 713/1313, and its ?author is Muhammad b. Abi Abdillâh Yahya b. Muhammad al-Hamâdî. He also consulted ?the copies in the libraries of Feyzullah Efendi, Edirne Serez and Ragıp Pasha.? In his work, which he wrote in a clear style, Taj al-Sharia commented in detail on some ?closed sentences that he received from al-Hidaya by mentioning it as qawluhû. He ?expressed the preferences of the Hanafi madhhab before him, in his own age, and ?sometimes with evidence, with phrases such as "and alayhi al-fatwa/fatwa is on him", "and ?bihi yuftâ/fatwa is given with this", "and bihi na'huzu/we take it", "and alayhi al-i'timad/ ?there is trust in it", etc. ? In the footnotes in our study; The verses and hadiths mentioned by the author in the text ?have been made tahrij, and information about the mentioned place, person, personal names ?and poems is given as an index in the appendix. In the dirâsa/introduction-evaluation ?section, the ISNAD citation rules and the principles of the ISAM investigation guide were ?used
Mustafa Kutlu'nun eserlerinde şehir ve mimari ilişkisi
No full textMustafa Kutlu, eserlerinde şehir ve mimari ilişkisini farklı biçimlerde işlemiştir. Hikâyeci kimliğiyle tanınan yazar deneme ve gezi yazılarında da ele aldığı şehir ve mimari konusunda geleneksel mimari ve modern mimari üzerinde durmuştur. Hikâyelerinde kurgusal yolla anlatıcıyla ve karakterler vasıtasıyla anlattığını; deneme ve gezi yazılarında doğrudan kendi sesiyle aktaran yazar, geleneksel mimariyi, modern mimariye tercih eder. Yazara göre modern şehirde kaybolan ahlakla beraber mimaride de üslupsuzluk görülmektedir ve bütün şehirler birbirine benzemektedir. Kutlu, geleneksel İslâm mimarisinde her evin küçük de olsa bir bahçesi olduğunu vurgular. Geleneksel şehirlerde insanın tabiatla ilişkisini sürdürdüğünü ancak modern şehirlerde betonlaşmayla bu ilişkinin kesildiğini söyleyen Kutlu, yeni şehirler kurulmasını teklif eder. Kurulacak yeni şehirlerde nüfus azaltılacak, mimari yapılaşma yatay olacaktır. Bir-iki katlı yapılacak evlerin her birinin birer bahçesi olacak ve yapılar iklim koşuluna uygun tasarlanacaktır. Bu araştırmanın amacı Mustafa Kutlu’nun eserlerinde şehir ve mimari ilişkisini tespit etmektir. Bu amaçla yazarın eserleri incelenmiş ve kronolojiye dikkat edilerek farklı başlıklar altında sınıflandırılmıştır.Mustafa Kutlu handled the relationship between city and architecture in different ways in his works. The author, who is known as a storyteller, focuses on traditional and modern architecture in his essays and travel writings on cities and architecture. In his stories, he tells the stories in a fictional way, through the narrator and the characters; The author, who narrates directly in his own voice in his essays and travel writings, prefers traditional architecture to modern architecture. According to the author, along with the lost morality in the modern city, there is also a lack of style in architecture and all cities look similar to each other. Kutlu emphasizes that in traditional Islamic architecture, every house has a garden, even if it is small. Kutlu says that in traditional cities, people maintain their relationship with nature, but in modern cities, this relationship is interrupted by concreting, and proposes the establishment of new cities. In new cities to be established, the population will be reduced and architectural construction will be horizontal. Each of the one- or two-storey houses will have a garden and the buildings will be designed according to the climatic conditions. The aim of this research is to determine the relationship between city and architecture in Mustafa Kutlu's works. For this purpose, the author's works were examined and classified under different headings, paying attention to chronology
Medical management of chronic subdural hematoma with low-dose hydrocortisone: a case series
No full textChronic subdural hematomas (cSDH) are often managed with a burr-hole craniostomy and drainage, but surgery is associated with elevated mortality, morbidity, and recurrence. Despite reports of steroid use for such patients, its efficacy and feasibility are still debated. We present our patient series treated with low-dose hydrocortisone. We retrospectively reviewed data from patients treated with hydrocortisone between 2017 and 2023. Demographics, clinical and radiological data were collected. Of 27 patients identified, nine required a burr-hole craniotomy for an average volume of 120.23 cm3, average midline shift of 9mm, and neurological deficits. Eighteen met the criteria for inclusion. The mean age was 78.5 years; 13 were male. None had severe symptoms requiring urgent intervention. Except for one with a Karnofsky Performance Scale score of 70, all could maintain normal activity before treatment. The mean baseline volume was 52.6 cm3. Midline shift, present in six, averaged 6.8mm. Patients underwent treatment for an average of 5.15 months. Nine had complete resolution within 3 months, while nine required longer treatment, including one who needed 9 months for a re-bleed after a fall. Paired t-tests indicated significant reductions in hematoma volumes at the second week (p 0.01), first month (p < 0.0001), and third month (p < 0.0001) of treatment. No complications occurred and the post-treatment Karnofsky scores ranged from 90 to 100. Treatment for cSDH should be tailored to the patient. Low-dose hydrocortisone is safe and effective in asymptomatic patients, those with mild to moderate symptoms, and those who are either unsuitable for or decline surgical intervention. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.The Yeditepe University Open Access System is a compendium of indexed publications. Copyright and usage rights may be held by publishers and/or authors. The collection was established for the scientific publications prepared by Yeditepe University academicians and is to be found in the institutional archive
The Role of Viruses in the Glioma Tumor Microenvironment: Immunosuppressors or Primers for Anti-Tumor Immunity?
No full textThe WHO estimates that nearly 10–15% of cancers have a known viral etiology, although this number is likely an underestimate. In glioblastoma (GBM), the most common primary brain malignancy, viral associations have been proposed and investigated without a definitive etiology. Viral–host interactions are known to alter cellular growth and stem cell programming, as well as modulate innate immune signaling. However, in GBM, the multifaceted role of endogenous or exogenous viral expression remains unclear. Here, we provide a review of common viral associations in GBM and discuss how these viruses modulate intrinsic cellular processes to enhance anti-viral immune response or suppress anti-tumor immunity
İçgörü ve Bilişsel Esnekliğin Psikolojik Dayanıklılık Üzerindeki Yordayıcı Etkisinin İncelenmesi
No full textIn this research, it was aimed to examine the effect of insight and cognitive flexibility on psychological hardiness. In the study group, there are a total of 390 participants, 248 women (Mean.age = 25.07, Sd = 5.48) and 142 men (Mean.age = 25.55, Sd = 5.23), aged between 18-44. Insight Scale, Cognitive Flexibility Scale and Psychological Hardiness Scale were used to collect data. Pearson Correlation Analysis and Multiple Linear Regression analysis were used to analyze the data. It was found that there is a positive and statistically significant relationship between Insight Scale scores and the Cognitive Flexibility Scale scores (r =.499, p <.01). It was determined that there is a positive and statistically significant relationship between Psychological Hardiness Scale scores with Insight Scale scores (r =.450, p <.01) and Cognitive Flexibility Scale scores (r =.599, p <.01). Also, it was observed that the Insight Scale scores (? =.201, t = 4.391, p =.000) and Cognitive Flexibility Scale scores (? =.498, t = 10.872, p =.000) significantly predicted the Psychological Hardiness Scale scores. According to the results of the research, insight and cognitive flexibility explain 38% of the total variance of psychological hardiness. The results of the research showed that the cognitive structures in particular and the psychological structures in general have an interactive and dynamic structure, and therefore the obvious importance of understanding each concept in psychological support services offered to people. © 2020 The Author(s)
Correction to:Investigating recurrence in pilonidal sinus disease: results of a nationwide, multicenter study in Turkey (PISI TURKEY) (International Journal of Colorectal Disease, (2025), 40, 1, (194), 10.1007/s00384-025-04921-x)
No full textThe collaborative Author names are missing in the published proof. The Supplementary material is updated with 2 additional names in the collaborative Author’s list. Ali Yalcinkaya, Ahmet Yalcinkaya, Sezai Leventoglu, Bengi Balci, Alp Ozgun Borcek, Elif Ozeller, Ece Ozturk, Gulsum Sueda Kayacan, Berkay Enes Karaca, Ahmet Faruk Oyanik, Omer Faruk Gul, Basak Bolukbasi, Huseyin Gobut, Cagri Buyukkasap, Aydin Yavuz, Dara Aydin, Zeynep Akdagcik, Alina Pataeva, Douigou Hasan, Omar Hussein, Arda Ozgur Ozturk, Cem Arda Elumar, Ali Derman Dere, Asra Zeynep Balci, Rasim Ozturk, Yasar Copelci, Murat Kartal, Serkan Tayar, Mustafa Yeni, Tolga Kalayci, Ramazan Yavuz, Bulent Calik, Semra Demirli Atici, Selen Ozturk, Gizem Kilinc, Korhan Tuncer, Cengiz Aydin, Mustafa Yener Uzunoglu, Alp Yildiz, Aybala Yildiz, Can Sahin, Mehmet Caglikulekci, Elbrus Zarbaliyev, Murat Sevmis, Baris Sevinc, Nurullah Damburaci, Omer Karahan, Ozgen Isik, Said Kural, Xhenet Hysejni, Ahmet Aktas, Baris Yildiz, Gultekin Ozan Kucuk, Ahmet Can Sari, Mert Candan, Mehmet Mahir Ozmen, Cem Emir Guldogan, Emre Gundogdu, Munevver Moran, Mevlut Recep Pekcici, Saygin Altiner, Enes Cebeci, Tugba Yigit, Bedri Burak Sucu, Mert Col, Omer Faruk, Ozkan Hanife, Seyda Ulgur, Murat Kalin, Emre Furkan Kirkan, Abdullah Yildiz, Sema Yukseksag, Cagri Buyukkasap, Erdinc Kamer, Mesut Ozogul, Nihan Acar, Melek Gokova Bekler, Arif Atay, Halis Bag, Server Sezgin Uludag, Ahmet Necati Sanli, Sefa Ergun, Ergin Erginoz, Veysi Basbayandur, Mehmet Faik Ozcelik, Ahmet Askar, Yuksel Altinel, Adnan Hacim, Serhat Meric, Merve Tokocin, Talar Aktokmakyan, Yunus Aktimur, Kamil Ozdogan, Fikret Calikoglu, Tugba Koc Calikoglu, Ahmet Barcin, Ahmed Salhat, Guray Durmaz, Volkan Ozben, Erman Aytac, Zumrud Aliyeva, Arda Ulas Mutlu, Mert Tanal, Mustafa Fevzi Celayir, Aydin Eray, Tufan Ali Yuksel, Elif Baran, Banu Yigit, Erhan Eroz, Aykhan Abbasov, Hakan Yanar, Huseyin Onur Aydin, Murathan Erkent, Tugan Tezcaner, Tevfik Avci, Murat Kus, Mehmet Abdussamet Bozkurt, Adem Ozcan, Nezihe Berrin Dodur Onalan, Serhan Yilmaz, Yasin Kara, Ali Kocatas, Fatih Yanar, Ali Fuat Kaan Gok, Irem Karatas, Berke Sengun, Ilknur Erenler Bayraktar, Onur Bayraktar, Zulal Emsal, Irem Dalkilic, Cengiz Dibekoglu, Sami Acar, Erman Ciftci, Yunus Yapalak, Cihad Tatar, Mert Mahsuni Sevinc, Ali Emre Nayci, Egemen Saygili, Yavuz Selim Komek, Bayram Kaymak, Fatih Altintoprak, Emrah Akin, Necattin Firat, Emre Gonullu, Ugur Can Dulger, Atilla Kurt, Sinan Soylu, Musa Serin, Omer Topcu, Ali Cihat Yildirim, Mehmet Fatih Ekici, Sezgin Zeren, Ismail Ahmet Bilgin, Tayfun Karahasanoglu, Ismail Hamzaoglu, Afag Aghayeva, Bilgi Baca, Inci Sahin, Osman Bozbiyik, Mustafa Ozgur Kilincarslan, Mustafa Ali Korkut, Erhan Akgun, Cemil Caliskan, Tayfun Yoldas, Timucin Erol, Hilmi Anil Dincer, Omer Cennet, Muhammed Salih Suer, Muhammet Bunyamin Dalkilic, Ibrahim Alkan, Busenur Kirimtay, Emre Balik, Emre Ozoran, Ibrahim Halil Ozata, Derya Salim Uymaz, Tutku Tufekci, Salih Nafiz Karahan, Orhan Agcaoglu, Naciye Cigdem Arslan, Mehmet Yilmaz, Orhan Ureyen, Can Murat Kale, Enver Ilhan, Eray Kara, Semra Tutcu Sahin, Onur Haspolat, Alperen Dalkiran, Ergun Yuksel, Mehmet Kocaoglu, Omer Tasan, Cevdet Tokat, Cihan Ozen, Alptug Mertcan Koc The Original article has been corrected.</p
Interhemispheric Transcingulate Sulcus Approach to Deep-Seated Medial Frontal and Parietal Lesions—Fiber Dissection Study With Illustrative Cases
No full textMachine learning applications in craniosynostosis diagnosis and treatment prediction: a systematic review
No full textCraniosynostosis refers to the premature fusion of one or more of the fibrous cranial sutures connecting the bones of the skull. Machine learning (ML) is an emerging technology and its application to craniosynostosis detection and management is underexplored. This systematic review aims to evaluate the application of ML techniques in the diagnosis, severity assessment, and predictive modeling of craniosynostosis. A comprehensive search was conducted on the PubMed and Google Scholar databases using predefined keywords related to craniosynostosis and ML. Inclusion criteria encompassed peer-reviewed studies in English that investigated ML algorithms in craniosynostosis diagnosis, severity assessment, or treatment outcome prediction. Three independent reviewers screened the search results, performed full-text assessments, and extracted data from selected studies using a standardized form. Thirteen studies met the inclusion criteria and were included in the review. Of the thirteen papers examined on the application of ML to the identification and treatment of craniosynostosis, two papers were dedicated to sagittal craniosynostosis, five papers utilized several different types of craniosynostosis in the training and testing of their ML models, and six papers were dedicated to metopic craniosynostosis. ML models demonstrated high accuracy in identifying different types of craniosynostosis and objectively quantifying severity using innovative metrics such as metopic severity score and cranial morphology deviation. The findings highlight the significant strides made in utilizing ML techniques for craniosynostosis diagnosis, severity assessment, and predictive modeling. Predictive modeling of treatment outcomes following surgical interventions showed promising results, aiding in personalized treatment strategies. Despite methodological diversities among studies, the collective evidence underscores ML's transformative potential in revolutionizing craniosynostosis management
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Machine learning applications in craniosynostosis diagnosis and treatment prediction: a systematic review
No full textCraniosynostosis refers to the premature fusion of one or more of the fibrous cranial sutures connecting the bones of the skull. Machine learning (ML) is an emerging technology and its application to craniosynostosis detection and management is underexplored. This systematic review aims to evaluate the application of ML techniques in the diagnosis, severity assessment, and predictive modeling of craniosynostosis. A comprehensive search was conducted on the PubMed and Google Scholar databases using predefined keywords related to craniosynostosis and ML. Inclusion criteria encompassed peer-reviewed studies in English that investigated ML algorithms in craniosynostosis diagnosis, severity assessment, or treatment outcome prediction. Three independent reviewers screened the search results, performed full-text assessments, and extracted data from selected studies using a standardized form. Thirteen studies met the inclusion criteria and were included in the review. Of the thirteen papers examined on the application of ML to the identification and treatment of craniosynostosis, two papers were dedicated to sagittal craniosynostosis, five papers utilized several different types of craniosynostosis in the training and testing of their ML models, and six papers were dedicated to metopic craniosynostosis. ML models demonstrated high accuracy in identifying different types of craniosynostosis and objectively quantifying severity using innovative metrics such as metopic severity score and cranial morphology deviation. The findings highlight the significant strides made in utilizing ML techniques for craniosynostosis diagnosis, severity assessment, and predictive modeling. Predictive modeling of treatment outcomes following surgical interventions showed promising results, aiding in personalized treatment strategies. Despite methodological diversities among studies, the collective evidence underscores ML's transformative potential in revolutionizing craniosynostosis management
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