944 research outputs found
Pulmonary vasoconstrictor action of KCNQ potassium channel blockers
Full text linkKCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important physiological functions. Recent reports indicate that KCNQ channels may also be expressed in portal vein where they are suggested to influence spontaneous contractile activity. The biophysical properties of K+ currents mediated by KCNQ channels resemble a current underlying the resting K+ conductance and resting potential of pulmonary artery smooth muscle cells. We therefore investigated a possible role of KCNQ channels in regulating the function of pulmonary arteries by determining the ability of the selective KCNQ channel blockers, linopirdine and XE991, to promote pulmonary vasoconstriction. Linopirdine and XE991 both contracted rat and mouse pulmonary arteries but had little effect on mesenteric arteries. In each case the maximum contraction was almost as large as the response to 50 mM K+. Linopirdine had an EC50 of around 1 μM and XE991 was almost 10-fold more potent. Neither removal of the endothelium nor exposure to phentolamine or α,β-methylene ATP, to block α1-adrenoceptors or P2X receptors, respectively, affected the contraction. Contraction was abolished in Ca2+-free solution and in the presence of 1 μM nifedipine or 10 μM levcromakalim
Veteran Law Students: Institutional Initiatives To Transform Their Law School Experiences
No full textPeer reviewe
Repositioning the graphic designer as researcher
Full text linkIn academic terms, the discipline of graphic design is relatively young. Consequently the position of the discipline within academic territory, and the role of the designer, continue to be debated. In part, these debates have been a product of attempts to define and defend the discipline’s borders from within, in order to establish a sense of the role of graphic design and the graphic designer as commensurate with other disciplines both within and beyond art and design. In recent years graphic designers have variously been defined as ‘authors’, ‘producers’ and ‘readers’, yet none of these definitions seem to have provided any kind of productive or lasting impact within the academy. This paper suggests that rather than continue to seek territorial definitions and positions from within, it could be more productive to look beyond the confines of the discipline. Gaining a broader, interdisciplinary perspective on, and understanding of, qualitative research methods from other disciplines may enable the graphic designer to more fully position his or her practice within the wider academy. Such a perspective could help facilitate the repositioning and redefinition of the graphic designer as ‘researcher’ - a move that would be productive in relation to the future development of postgraduate research within the discipline
Terms of inclusion? Rejecting the role of 'honorary man' in the ivory tower
No full textThe chapter, "Terms of inclusion? Rejecting the role of 'honorary man' in the ivory tower" was written by Alison M. Thomas (Douglas College Faculty). Featuring many personal accounts, the twenty-four essays in this collection explore the challenges and possibilities confronting those, especially women, who combine parenting and academic work. Written by a diverse group of educators who present a real-world variety of situations, the collection also includes ideas for change at the individual, interpersonal, policy, and system levels.book chapterPublished
Mining e-mail content for author identification forensics
No full textWe describe an investigation into e-mail content mining for author identification, or authorship attribution, for the purpose of forensic investigation. We focus our discussion on the ability to discriminate between authors for the case of both aggregated e-mail topics as well as across different email topics. An extended set of e-mail document features including structural characteristics and linguistic patterns were derived and, together with a Support Vector Machine learning algorithm, were used for mining the e-mail content. Experiments using a number of e-mail documents generated by different authors on a set of topics gave promising results for both aggregated and multi-topic author categorisation
Beyond Black & White : Race, Ethnicity, and Gender in the U.S. South and Southwest
No full textEdited by Stephanie Cole & Alison M. Parker [College at Brockport faculty member] ; introduction by Nancy A. Hewitt [College at Brockport alum].
“The complex, changing and oppressive ‘multiracisms’—to use Ronit Lentin\u27s term—of the U.S. South and Southwest are brilliantly captured in this powerful collection of linked essays. So too are the ways in which differing but overlapping experiences of race, citizenship and terror created both common ground and grounds for division among racialized groups.”--David Roediger, University of Illinois, and author, Colored White: Transcending the Racial Pasthttps://digitalcommons.brockport.edu/bookshelf/1279/thumbnail.jp
Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery
Full text linkUridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors. Pharmacological characterisation of these receptors in intact arteries is complicated by release and extracellular metabolism of nucleotides, so the aim of this study was to characterise the P2Y receptors under conditions that minimise these problems. ATP, UTP and UDP (10-4M) evoked oscillating, inward currents (peak = 13-727 pA) in 71-93% of cells. The first current was usually the largest and in the SPA the response to ATP was significantly greater than those to UTP or UDP (P < 0.05). Subsequent currents tended to decrease in amplitude, with a variable time-course, to a level that was significantly smaller for ATP (P < 0.05), UTP (P < 0.001) and UDP (P < 0.05) in the SPA. The frequency of oscillations was similar for each agonist (mean≈6-11.min-1) and changed little during agonist application. The non-selective P2 receptor antagonist suramin (10-4M) abolished currents evoked by ATP in SPA (n = 4) and LPA (n = 4), but pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) (10-4M), also a non-selective P2 antagonist, had no effect (n = 4, 5 respectively). Currents elicited by UTP (n = 37) or UDP (n = 14) were unaffected by either antagonist. Contractions of SPA evoked by ATP were partially inhibited by PPADS (n = 4) and abolished by suramin (n = 5). Both antagonists abolished the contractions in LPA
Language and gender author cohort analysis of e-mail for computer forensics
No full textAbstract. We describe an investigation of authorship gender and lan-guage background cohort attribution mining from e-mail text documents. We used an extended set of predominantly topic content-free e-mail document features such as style markers, structural characteristics and gender-preferential language features together with a Support Vector Machine learning algorithm. Experiments using a corpus of e-mail doc-uments generated by a large number of authors of both genders gave promising results for both author gender and language background co-hort categorisation.
Do UK based weight management programmes cause weight loss maintenance in adults? A systematic review
Full text linkThe aim of this dissertation was to examine whether UK based weight management programmes promote weight loss maintenance (follow up of 12 months to assess effectiveness of intervention in weight loss) in adults through the process of a systematic review. The World Health Organisation (WHO) has described obesity as a "global epidemic". Weight management comprises two phases; weight loss and weight loss maintenance. The latter phase is the true goal for obesity and the most difficult element of weight management to achieve. However much less is know about this as compared with the weight loss phase. There is little purpose in committing time and money to reducing obesity if the weight is regained. This is counter-productive and weight loss maintenance is essential to combat the obesity epidemic. Searches were made for relevant information from a variety of scientific online databases and journals,. Seven articles met the inclusion criteria and were analysed in the review. All studies incorporated a multi-component (diet, exercise, behaviur modification) intervention approach. All control and internvetion groups reported weight loss at 12 months when compared with baseline. All groups recieved an intervention. One study reported a significant difference (P<0.05) between groups. Four studies reported on at least one component (diet, physical activity, behaviour modification) however there was not enough information to conclude whether they complied with national guidelines (NICE CG43 and SIGN 115). High attrition rates and loss to follow up are problematic for each study except one. Analysis on an intention to treat basis was common however this is problematic and there are alternative methods which may be more suitable for dealing with missing data
Supermoms and bumbling dads: How do Mother's Day and Father's Day cards help perpetuate traditional roles in the home?
No full textThe chapter, "Supermoms and bumbling dads: How do Mother's Day and Father's Day cards help perpetuate traditional roles in the home?" was written by the listed authors including Alison M. Thomas (Douglas College Faculty). Life in Canada is marked, celebrated, enjoyed, and dreaded in ways that respond specifically to the seasons. Sociological thinking allows people to ask questions about things that may otherwise be taken for granted. Thinking about the seasons sociologically opens up a unique perspective for studying and understanding social life. Each chapter in this collection approaches the seasons and the passage of time as a way to explore issues of sociological interest. The authors use seasonality as a device that can bridge, in fascinating ways, small-scale interpersonal interactions and large formal institutional structures. These contemporary, Canadian case studies are wide-ranging and include analyses of pumpkin spice lattes, policing in schools, law and colonialism, summer cottages, seasonal affective disorder, New Year’s resolutions, Vaisakhi celebrations, and more. Seasonal Sociology offers provocative new ways of thinking about the nature of our collective lives. --From publisher description.book chapterPublished
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