90 research outputs found

    sj-docx-1-dhj-10.1177_20552076211039032 - Supplemental material for Change in cardiometabolic risk factors among Asian Indian adults recruited in a mHealth-based diabetes prevention trial

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    Supplemental material, sj-docx-1-dhj-10.1177_20552076211039032 for Change in cardiometabolic risk factors among Asian Indian adults recruited in a mHealth-based diabetes prevention trial by Shruti Muralidharan, Harish Ranjani, Ranjit Mohan Anjana, Yashdeep Gupta, Samita Ambekar, Varsha Koppikar, N Jagannathan, Sidhant Jena, Nikhil Tandon, Steven Allender and Viswanathan Mohan in Digital Health</p

    Glucocorticoid-induced myopathy: Pathophysiology, diagnosis, and treatment

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    Glucocorticoid-induced myopathy is the most common type of drug-induced myopathy. Nearly 60% of patients with Cushing′s syndrome have muscle weakness. Glucocorticoid-induced muscle atrophy affects mainly fast-twitch glycolytic muscle fibers (type IIb fibers). This brief review will discuss the pathophysiology behind glucocorticoid-induced myopathy, along with diagnostic features and treatment

    Insulin-derived amyloidosis

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    Amyloidosis is the term for diseases caused by the extracellular deposition of insoluble polymeric protein fibrils in tissues and organs. Insulin-derived amyloidosis is a rare, yet significant complication of insulin therapy. Insulin-derived amyloidosis at injection site can cause poor glycemic control and increased insulin dose requirements because of the impairment in insulin absorption, which reverse on change of injection site and/or excision of the mass. This entity should be considered and assessed by histopathology and immunohistochemistry, in patients with firm/hard local site reactions, which do not regress after cessation of insulin injection at the affected site. Search strategy: PubMed was searched with terms "insulin amyloidosis". Full text of articles available in English was reviewed. Relevant cross references were also reviewed. Last search was made on October 15, 2014

    Essential Medicines for Children: An Endocrine Perspective

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    The emergence of endocrine disease has created significant challenges for healthcare policy-makers and payers across the world. Policy-makers have to ensure availability of drugs used for various endocrinopathies. One way in which this is facilitated is through the World Health Organization (WHO) List of Essential Medicines (LEM). The LEM aims to cover the basic pharmaceutical needs of the majority of people seeking healthcare (1)

    Insulin technique

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    Updated guidelines on screening for gestational diabetes

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    Yashdeep Gupta,1 Bharti Kalra,2 Manash P Baruah,3 Rajiv Singla,4 Sanjay Kalra2 1Department of Medicine, Government Medical College and Hospital, Chandigarh, India; 2Bharti Hospital, Karnal, Haryana, India; 3Excel Center, Guwahati, Assam, India; 4Saket City Hospital, New Delhi, India Abstract: Gestational diabetes mellitus (GDM) is associated with an increased risk of complications for both mother and baby during pregnancy as well as in the postpartum period. Screening and identifying these high-risk women is important to improve short- and long-term maternal and fetal outcomes. However, there is a lack of international uniformity in the approach to the screening and diagnosis of GDM. The main purpose of this review is to provide an update on screening for GDM and overt diabetes during pregnancy, and discuss the controversies in this field. We take on debatable issues such as adoption of the new International association of diabetes and pregnancy study groups criteria instead of the Carpenter and Coustan criteria, one-step versus two-step screening, universal screening versus high-risk screening before 24 weeks of gestation for overt diabetes, and, finally, the role of HbA1c as a screening test of GDM. This discussion is followed by a review of recommendations by professional bodies. Certain clinical situations, in which a pragmatic approach is needed, are highlighted to provide a comprehensive overview of the subject. Keywords: pregnancy, guidelines, IADPSG, GDM, Carpenter and Coustan criteri
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