66 research outputs found

    Fig. 7 in Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities

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    Fig. 7. ORTEP drawing of compound 11.Published as part of Zhan, Guanqun, Miao, Rongkun, Zhang, Fuxin, Hao, Xincai, Zheng, Xi, Zhang, Hui, Zhang, Xinxin & Guo, Zengjun, 2020, Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities, pp. 1-9 in Phytochemistry (112450) 177 on page 6, DOI: 10.1016/j.phytochem.2020.112450, http://zenodo.org/record/829590

    Fig. 1 in Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities

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    Fig. 1. Chemical structures of MIAs 1−20.Published as part of Zhan, Guanqun, Miao, Rongkun, Zhang, Fuxin, Hao, Xincai, Zheng, Xi, Zhang, Hui, Zhang, Xinxin & Guo, Zengjun, 2020, Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities, pp. 1-9 in Phytochemistry (112450) 177 on page 2, DOI: 10.1016/j.phytochem.2020.112450, http://zenodo.org/record/829590

    Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities

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    Zhan, Guanqun, Miao, Rongkun, Zhang, Fuxin, Hao, Xincai, Zheng, Xi, Zhang, Hui, Zhang, Xinxin, Guo, Zengjun (2020): Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities. Phytochemistry (112450) 177: 1-9, DOI: 10.1016/j.phytochem.2020.112450, URL: http://dx.doi.org/10.1016/j.phytochem.2020.11245

    Fig. 6 in Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities

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    Fig. 6. ORTEP drawing of compound 4.Published as part of Zhan, Guanqun, Miao, Rongkun, Zhang, Fuxin, Hao, Xincai, Zheng, Xi, Zhang, Hui, Zhang, Xinxin & Guo, Zengjun, 2020, Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities, pp. 1-9 in Phytochemistry (112450) 177 on page 6, DOI: 10.1016/j.phytochem.2020.112450, http://zenodo.org/record/829590

    Fig. 3 in Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities

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    Fig. 3. Key NOESY correlations of 1, 4, and 9.Published as part of Zhan, Guanqun, Miao, Rongkun, Zhang, Fuxin, Hao, Xincai, Zheng, Xi, Zhang, Hui, Zhang, Xinxin & Guo, Zengjun, 2020, Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities, pp. 1-9 in Phytochemistry (112450) 177 on page 4, DOI: 10.1016/j.phytochem.2020.112450, http://zenodo.org/record/829590

    Fig. 5 in Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities

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    Fig. 5. Comparison of the experimental and calculated ECD spectra of 3.Published as part of Zhan, Guanqun, Miao, Rongkun, Zhang, Fuxin, Hao, Xincai, Zheng, Xi, Zhang, Hui, Zhang, Xinxin & Guo, Zengjun, 2020, Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities, pp. 1-9 in Phytochemistry (112450) 177 on page 4, DOI: 10.1016/j.phytochem.2020.112450, http://zenodo.org/record/829590

    Fig. 4 in Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities

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    Fig. 4. Comparison of the experimental ECD spectra of 1 and 18 in MeOH.Published as part of Zhan, Guanqun, Miao, Rongkun, Zhang, Fuxin, Hao, Xincai, Zheng, Xi, Zhang, Hui, Zhang, Xinxin & Guo, Zengjun, 2020, Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities, pp. 1-9 in Phytochemistry (112450) 177 on page 4, DOI: 10.1016/j.phytochem.2020.112450, http://zenodo.org/record/829590

    Fig. 2. 1H–1H in Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities

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    Fig. 2. 1H–1H COSY, key HMBC correlations of 1, 4, and 9.Published as part of Zhan, Guanqun, Miao, Rongkun, Zhang, Fuxin, Hao, Xincai, Zheng, Xi, Zhang, Hui, Zhang, Xinxin & Guo, Zengjun, 2020, Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities, pp. 1-9 in Phytochemistry (112450) 177 on page 3, DOI: 10.1016/j.phytochem.2020.112450, http://zenodo.org/record/829590

    Pharmacokinetic evaluation of the interaction between oral kaempferol and ethanol in rats

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    This study was aimed at investigating the effect of ethanol on oral bioavailability of kaempferol in rats, namely, at disclosing their possible interaction. Kaempferol (100 or 250 mg kg–1 bm) was administered to the rats by oral gavage with or without ethanol (600 mg kg–1 bm) co-administration. Intravenous administration (10 and 25 mg kg–1 bm) of kaempferol was used to determine the bioavailability. The concentration of kaempferol in plasma was estimated by ultra high performance liquid chromatography. During co-administration, significant increase of the area under the plasma concentration-time curve as well as the peak concentration were observed, along with a dramatic decrease in total body clearance. Consequently, the bioavailability of kaempferol in oral control groups was 3.1 % (100 mg kg–1 bm) and 2.1 % (250 mg kg–1 bm). The first was increased by 4.3 % and the other by 2.8 % during ethanol co-administration. Increased permeability of cell membrane and ethanol-kaempferol interactions on CYP450 enzymes may enhance the oral bioavailability of kaempferol in rats
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