698 research outputs found
Ju Chao hua yi yan jiu
No full text郭玉美.論文(哲學碩士) -- 香港中文大學硏究院中國藝朮史哲學碩士課程, 1996.參考文献 : leaves 184-190.Guo Yumei.論文撮要緖論 --- p.1Chapter 第一章 --- 居巢生平 --- p.6Chapter 第一節： --- 時代背景 --- p.6Chapter 第二節： --- 生平傳略及家族背景 --- p.10Chapter 第三節： --- 生平經歷 --- p.18Chapter -- --- 廣画時期 --- p.18Chapter -- --- 東莞時期 --- p.32Chapter -- --- 隔山時期 --- p.43Chapter 第二章 --- 居巢的畫藝歷程 --- p.63Chapter 第一節： --- 師承淵源 --- p.64Chapter 第二節： --- 繪畫風格探硏 --- p.75Chapter -- --- 前期：1847年以前 --- p.75Chapter -- --- 中期：（1847-1856 ) --- p.79Chapter -- --- 後期：(1856-1865 ) --- p.93Chapter 第三章 --- 詩詞與畫藝 --- p.113Chapter 第一節： --- 居巢的詩與詞 --- p.113Chapter 第二節： --- 居巢的詩與畫 --- p.126Chapter 第三節： --- 從題畫詩中探討居巢之藝術理論 --- p.131Chapter 第四章 --- 居巢與居廉 --- p.143Chapter 第一節： --- 親屬情誼 --- p.143Chapter 第二節： --- 畫藝傳承 --- p.144Chapter 第三節： --- 二居畫藝比較 --- p.155Chapter 第四節： --- 成就及影響 --- p.164結語 --- p.179參考書目 --- p.184附錄（一）居巢年譜 --- p.191附錄（二） 居巢作品編年圖錄 --- p.198圖版 --- p.2.1--2.45附錄（三）各章繪畫插圖目錄 --- p.201插圖圖版 --- p.3.1--3.19附錄（四）生活照片插圖目錄- --- p.205插圖圖版 --- p.4.1--4.14謝辭 --- p.20
Supplemental_Material - A study on dispersions of CB and CNT in PP/EPDM composites and their mechanical reinforcement
No full textSupplemental_Material for A study on dispersions of CB and CNT in PP/EPDM composites and their mechanical reinforcement by Xiaohang Tuo, Guizhi Ma, Qian Tan, Yumei Gong and Jing Guo in Polymers and Polymer Composites</p
Resilience planning maps and guidance
No full textby Yumei Wang and Jon J. Franczyk.Title from PDF cover (viewed on May 29, 2020)."This publication is intended to help hospitals with their efforts toward building disaster resilience"--Page 1.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
Remote brain network changes after unilateral cortical impact injury and their modulation by Acetylcholinesterase inhibition
Get PDFWe explored whether cerebral cortical impact injury (CCI) effects extend beyond direct lesion sites to affect remote brain networks, and whether acetylcholinesterase (AChE) inhibition elicits discrete changes in functional activation of motor circuits following CCI. Adult male rats underwent unilateral motor-sensory CCI or sham injury. Physostigmine (AChE inhibitor) or saline were administered subcutaneously continuously via implanted minipumps (1.6 micromoles/kg/day) for 3 weeks, followed by cerebral perfusion mapping during treadmill walking using [14C]-iodoantipyrine. Quantitative autoradiographs were analyzed by statistical parametric mapping and functional connectivity (FC) analysis. CCI resulted in functional deficits in the ipsilesional basal ganglia, with increased activation contralesionally. Recruitment was also observed, especially contralesionally, of the red nucleus, superior colliculus, pedunculopontine tegmental nucleus, thalamus (ventrolateral n., central medial n.), cerebellum, and sensory cortex. FC decreased significantly within ipsi- and contralesional motor circuits and between hemispheres, but increased between midline cerebellum and select regions of the basal ganglia within each hemisphere. Physostigmine significantly increased functional brain activation in the cerebellar thalamocortical pathway (midline cerebellum/ventrolateral thalamus/motor cortex), subthalamic nucleus/zona incerta, and red nucleus and bilateral sensory cortex. In conclusion, CCI resulted in increased functional recruitment of contralesional motor cortex and bilateral subcortical motor regions, as well as recruitment of the cerebellar– thalamocortical circuit and contralesional sensory cortex. This phenomenon, augmented by physostigmine, may partially compensate motor deficits. FC decreased inter-hemispherically and in negative, but not positive, intra-hemispherical FC, and it was not affected by physostigmine. Circuit-based approaches into functional brain reorganization may inform future behavioral or molecular strategies to augment targeted neurorehabilitation.Fil: Holschneider, Daniel P.. University of California at Los Angeles; Estados UnidosFil: Guo, Yumei. University of California at Los Angeles; Estados UnidosFil: Wang, Zhuo. University of California at Los Angeles; Estados UnidosFil: Roch, Margareth. University of California at Los Angeles; Estados UnidosFil: Scremin, Oscar Umberto. University of California at Los Angeles; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Earthquake regional impact analysis for Columbia County, Oregon and Clark County, Washington
No full textby John M. Bauer, Recep Cakir, Corina Allen, Kate Mickelson, Trevor Contreras, Robert Hairston-Porter, and Yumei Wang.Title from PDF cover (viewed on March 30, 2020)."This is the second of two reports that document the estimated impacts of a major earthquake on the Portland, Oregon metropolitan region. Both reports were prepared for the Regional Disaster Preparedness Organization (RDPO), with funding provided by the Urban Areas Security Initiative Program. The reports provide damage estimates to buildings and key infrastructure sectors resulting from a major earthquake in the Portland metropolitan region, along with casualty estimates, by using updated local geologic information and recent advances in earthquake loss estimation methods. Damage and casualty estimates are tabulated at county, jurisdiction, and neighborhood levels, providing actionable information for further use in emergency planning, earthquake mitigation, public awareness, and post-earthquake response and recovery"--Page 1.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (pages 47-54).Funding provided by the Urban Areas Security Initiative Program.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
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No full textEpsin is an evolutionarily conserved endocytic clathrin adaptor whose most critical function(s) in clathrin coat dynamics remain(s) elusive. To elucidate such function(s), we generated embryonic fibroblasts from conditional epsin triple KO mice. Triple KO cells displayed a dramatic cell division defect. Additionally, a robust impairment in clathrin-mediated endocytosis was observed, with an accumulation of early and U-shaped pits. This defect correlated with a perturbation of the coupling between the clathrin coat and the actin cytoskeleton, which we confirmed in a cell-free assay of endocytosis. Our results indicate that a key evolutionary conserved function of epsin, in addition to other roles that include, as we show here, a low affinity interaction with SNAREs, is to help generate the force that leads to invagination and then fission of clathrin-coated pits.Clathrin-dependent endocytosis is one of the mechanisms used by cells to internalize specific proteins (cargo) from their surface. First, the cargo interacts with adaptor proteins that help cluster them in the cell's outer membrane, called the plasma membrane. This causes the protein clathrin to assemble into a lattice at the cytosolic side of the plasma membrane and deform the membrane into a pit. The pit grows deeper over time as more clathrin molecules assemble, eventually resulting in a deeply invaginated clathrin-coated pit that encloses the cargo to be taken up by the cell. The clathrin-coated pit then pinches off inside the cell in a process called fission to form a bubble-like structure called a vesicle, which transports the molecule to its destination. The deep invagination of clathrin-coated pits that leads to fission is assisted by actin, a protein that assembles into filaments that are suggested to generate the forces needed for this process. Many other factors are also involved. One of them is epsin, the collective name for a family of three very similar proteins in mammalian cells. Epsin binds to several other proteins implicated in clathrin-dependent endocytosis, including clathrin itself, and to plasma membrane proteins specifically ‘tagged’ for internalization. In addition, a portion of the epsin molecule can insert into the plasma membrane and help it to curve, which is important for forming the invaginated pit. However, due to the number of possible functions epsin could perform, its main role has remained elusive. Messa et al. created mouse cells that lack all three epsin proteins. Although these cells can form clathrin-coated pits, they struggle to develop into vesicles. The normal linking of the actin filaments to the clathrin coat does not occur, and another protein called Hip1R that also participates in clathrin-mediated endocytosis and links clathrin to actin, no longer accumulates at the clathrin-coated pits. Messa et al. also find that epsins can bind directly to actin. Overall, these results suggest that a main role of epsin is to help actin interact with the clathrin-coated pits and generate the force required for a pit to develop into a vesicle. However, epsin also performs many other roles, including recruiting a membrane protein (a so-called SNARE) that directs the fate of the vesicle to the clathrin-coated pit. Additionally, Messa et al. find that cells lacking all three epsins have problems dividing correctly. More research is required to establish whether this effect is also due to epsin's interaction with the cell's actin cytoskeleton.Epsin is an evolutionarily conserved endocytic clathrin adaptor whose most critical function(s) in clathrin coat dynamics remain(s) elusive. To elucidate such function(s), we generated embryonic fibroblasts from conditional epsin triple KO mice. Triple KO cells displayed a dramatic cell division defect. Additionally, a robust impairment in clathrin-mediated endocytosis was observed, with an accumulation of early and U-shaped pits. This defect correlated with a perturbation of the coupling between the clathrin coat and the actin cytoskeleton, which we confirmed in a cell-free assay of endocytosis. Our results indicate that a key evolutionary conserved function of epsin, in addition to other roles that include, as we show here, a low affinity interaction with SNAREs, is to help generate the force that leads to invagination and then fission of clathrin-coated pits.Clathrin-dependent endocytosis is one of the mechanisms used by cells to internalize specific proteins (cargo) from their surface. First, the cargo interacts with adaptor proteins that help cluster them in the cell's outer membrane, called the plasma membrane. This causes the protein clathrin to assemble into a lattice at the cytosolic side of the plasma membrane and deform the membrane into a pit. The pit grows deeper over time as more clathrin molecules assemble, eventually resulting in a deeply invaginated clathrin-coated pit that encloses the cargo to be taken up by the cell. The clathrin-coated pit then pinches off inside the cell in a process called fission to form a bubble-like structure called a vesicle, which transports the molecule to its destination. The deep invagination of clathrin-coated pits that leads to fission is assisted by actin, a protein that assembles into filaments that are suggested to generate the forces needed for this process. Many other factors are also involved. One of them is epsin, the collective name for a family of three very similar proteins in mammalian cells. Epsin binds to several other proteins implicated in clathrin-dependent endocytosis, including clathrin itself, and to plasma membrane proteins specifically \‘tagged\’ for internalization. In addition, a portion of the epsin molecule can insert into the plasma membrane and help it to curve, which is important for forming the invaginated pit. However, due to the number of possible functions epsin could perform, its main role has remained elusive. Messa et al. created mouse cells that lack all three epsin proteins. Although these cells can form clathrin-coated pits, they struggle to develop into vesicles. The normal linking of the actin filaments to the clathrin coat does not occur, and another protein called Hip1R that also participates in clathrin-mediated endocytosis and links clathrin to actin, no longer accumulates at the clathrin-coated pits. Messa et al. also find that epsins can bind directly to actin. Overall, these results suggest that a main role of epsin is to help actin interact with the clathrin-coated pits and generate the force required for a pit to develop into a vesicle. However, epsin also performs many other roles, including recruiting a membrane protein (a so-called SNARE) that directs the fate of the vesicle to the clathrin-coated pit. Additionally, Messa et al. find that cells lacking all three epsins have problems dividing correctly. More research is required to establish whether this effect is also due to epsin's interaction with the cell's actin cytoskeleton
Design against loneliness: service design toollkit for social connectivity among the elderly
No full textLoneliness, as a social problem, has drawn wide attention of the academic and public. Moreover, loneliness among the elderly is significant. Up to 32% of adults older than age 55 report feeling lonely at any given time. Millions of euro have spent to identify the lonely elderly. With a great interest in social design, the author is intrigued by this issue and thus, initiated the project with an attempt to make a contribution to it with design methods.In the research phase, extensive literature constructed a holistic view of the loneliness and yielded a new perspective of understanding it. Loneliness is like the destination of the vicious circle between negative social interaction and negative social cognition. Moreover, it may spread through negative interaction. Thereby, the project focuses on social interaction as the entry point for intervention. Through partnering with Vierstroom, one elderly home care company who is also interested in connecting their elderly members, the project finds a context for designer’s intervention. It is activities organized by the Vierstroom and Palet welfare such as bingo game, or care lecture. Investigation of the context revealed dozens of problems and opportunities. There are five pain points highlighted in the elderly activity: the reliance of facilitator, the passive social attitude, the negative social norm, the negative complaining and the one-way communication.A new relationship between elderly and organization: sports fan and coachAnalysis and ideation provoke a vision that elderly and organization could be like sports fan and coach. With service design methods, the author paves the road to vision by seeing the activity as multiple-layers and sequential interaction. After that, a service strategy is synthesized with four steps for four sub-visions. Moreover, the strategy is translated into 15 design guidelines. Thereby, organizations could adopt the guidelines to enhance their service or generative service ideas in various cases. <br/
Real Exchange Rate, Foreign Trade and Employment: Evidence from China
Get PDFCoordination of macro-economic development and employment is an essential issue for China's social development, which largely depends on economic expansion, as well as integration into the global market to create jobs. Through the literature review and empirical test, this paper analyses the relationship between macro-economic policy and employment, and discusses the impact of real exchange rate and foreign trade on employment. The research indicates that a stable and competitive exchange rate policy plays an indispensable role in employment promotion, more effective than monetary and fiscal policies, while the export growth also plays a positive role in employment promotion.China, employment, foreign trade, real exchange rate
RETRACTED ARTICLE: Down-regulation of lncRNA FEZF1-AS1 mediates regulatory T cell differentiation and further blocks immune escape in colon cancer
No full textWe, the Editors and Publisher of the journal Expert Review of Molecular Diagnostics, have retracted the following article: Sen Hong, Zhenkun Yan, YuMei Song, MiaoMiao Bi & Shiquan Li. Down-regulation of lncRNA FEZF1-AS1 mediates regulatory T cell differentiation and further blocks immune escape in colon cancer. Expert Review of Molecular Diagnostics. 2021. DOI: 10.1080/14737159.2022.2012157 Since publication, significant concerns have been raised about the integrity of the data and reported results in the article. When approached for an explanation, the authors did not provide their original data or any necessary supporting information. As verifying the validity of published work is core to the integrity of the scholarly record, we are therefore retracting the article. The corresponding author listed in this publication has been informed. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted’.</p
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