581 research outputs found
The "adaptive responses" of low concentrations of HBCD in L02 cells and the underlying molecular mechanisms
No full textThis study aimed to investigate the "adaptive responses" of hexabromocyclododecanes (HBCD) at environmentally relevant concentrations in human hepatocytes L02. L02 cells were pre-treated with low concentrations of HBCD (10(-13)-10(-11) M), followed by treatment with high concentrations of HBCD, alpha-hexachlorocyclohexane (alpha-HCH), polychlorinated biphenyls (PCBs), or polybrominated diphenyl ether-47 (BDE47). The results showed that the pre-treatment with low concentrations of HBCD induced "adaptive responses" to high concentrations of HBCD/alpha-HCH exposure (but not to PCBs and BDE47), as evidenced by attenuation of survival inhibition, reactive oxygen species (ROS) over-production, and deoxyribonucleic acid (DNA) damage induction. The "adaptive responses" induced by low concentrations of HBCD, which depended on the activation of the phosphatidylinositide 3-kinase/protein kinase B (PI3K/Akt) pathway, reduced the phosphorylation of adenosine monophosphate-activated kinase (AMPK) and enhanced the phosphorylation of p38 mitogen-activated protein kinases (p38 MAPK). The observations were further confirmed by the experiments with inhibitors. Moreover, the evaluation on the changes of metabolic enzymes revealed that HBCD and alpha-HCH shared a similar pattern of cytochrome P450 induction (CYP2B6), which was different from those of PCBs and BDE47 (CYP1A1 and CYP2B6). These results indicated that low concentrations of HBCD could induce "adaptive responses" to the subsequent treatment with high concentrations of HBCD/alpha-HCH in L02 cells, which was associated with the PI3K/Akt pathway, and AMPK and p38 MAPK signaling. The "adaptive responses" seemed to be dependent on the types of chemicals in terms of the metabolic patterns and chemical structures. (C) 2015 Elsevier Ltd. All rights reserved
An Algorithm of Functional Gradient Thermal Barrier Coating Material Running on Parallel Computing
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Constructing Cantonese-nesses: Relocations and Remediations of Chao Shao-an’s Paintings across the Asia-Pacific, c. 1950s- 2010s
No full textThis thesis defines and deconstructs what the author calls the “Chao Shao-an Phenomenon”, and analyses how Chao’s paintings have been disseminated and represented by himself and his followers in different regions in the Asia-Pacific since the mid-20th century. It argues that these different representations of Chao’s paintings have been effectively constructing different forms of Cantonese identities for different Cantonese communities in relation to the various local cultural politics. Readers can expect five chapters, each of which focuses on one representation of Chao’s paintings in one region in the making of one form of Cantonese identity. These representations encompass a wide range, including but not limited to reproduction and publication, art-history writing, imitation, exhibition sites, and the collecting of Chao’s works, respectively, in Hong Kong, Taiwan, San Francisco, Guangzhou, and Singapore. Breaking through the overwhelming, standard biographical narrative of Chao, as well as the general visual analysis of his works that is limited to descriptions of his major painting techniques, this research aims to open new directions in the fields of art history and social history in three ways. Firstly, with its cross-regional scope, it puts forward a more local-global mapping and perspective in narrating the biography of Chao’s oeuvres beyond their general labels of “Chinese art” and the “Lingnan School”. Secondly, by examining the intermediality between painting and the series of forms of popular media listed above, it urges a closer visual and sociological investigation of the very process of how an artwork can access to and generate meanings to a wider public. Thirdly, more broadly, it hopes to demonstrate the ways how diaspora studies — which often marginalises visual materials and analysis — can be bridged with art history to enrich and complicate the existing scholarship on the making of Cantonese and Chinese identities in the 20th century
Disturbance Evolution Behavior of Loess Soil under Triaxial Compression
No full textThis paper presents an investigation into the evolution law of the structural effects of Xi’an loess soil, based on the disturbed state concept. First, a series of consolidated and drained triaxial compression tests were performed on undisturbed and remoulded loess samples prepared at five different moisture contents and tested at four different confining pressures. Second, two disturbance functions with different parameters were proposed to quantify mathematically the structural effects of loess. Finally, the proposed disturbance functions were validated against documented test results by other researchers. The results indicated that the single-parameter disturbance function, with the deformation modulus as its parameter, provides convenience for application but takes no account of the respective contributions of deviatoric stress and mean stress to the disturbance evolution behavior of loess. The double-parameter disturbance function, with the shear and bulk moduli as its parameters, is capable of distinguishing these respective contributions and reflects well the disturbance evolution behavior of loess under various moisture contents and confining pressures. The effects of moisture content and confining pressure on the parameters of the disturbance functions were found to be unsteady. The proposed disturbance functions lay the foundation for establishing a constitutive model for loess accounting for the structural effect
A Friction Coefficient Principal Component Algorithm of Water Lubricated Bearing Composite Material
No full textDesign and Implementation of Intelligent Medical Customer Service Robot Based on Deep Learning
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Development of an ultrasensitive electrochemiluminescence inhibition method for the determination of tetracyclines
No full textAssessment on China's urbanization after the implementation of main functional areas planning
No full textChina has implemented main functional areas planning (MFAP) since 2010, which is essential for improving the efficiency of land space utilization and achieving sustainable urban development. Quantitative assessments of the urban development levels (UDLs) at the county level across China after the implementation of MFAP have not been well-documented. In this study, a unified indicator system was developed, and the UDLs of 2850 counties in China after MFAP implementation were evaluated. The results showed that MFAP played a positive role in urban development in China. The UDLs in China generally increased but showed obvious spatial differences. The higher UDLs were mostly found in the counties in the five urban belts, which reflects the overall urban layout of China. The UDLs were generally low in the western counties in comparison with those in the eastern part of China. The differences in the UDLs from east to west were greater than those from north to south. Moreover, the differences in the UDLs presented a spatial agglomeration effect. This study could offer insight into the refinement of MFAP in China and sustainable urban development in developing countries.Accepted Author ManuscriptHydraulic Structures and Flood Ris
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