489 research outputs found
Supplemental Material2 - Supplemental material for Long non-coding RNA profiling in LPS-induced intestinal inflammation model: New insight into pathogenesis
No full textSupplemental material, Supplemental Material2 for Long non-coding RNA profiling in LPS-induced intestinal inflammation model: New insight into pathogenesis by Ling Guo, Linna Li, Yang Zhang, Shulin Fu, Jing Zhang, Xiuying Wang, Huiling Zhu, Mu Qiao, Lingying Wu and Yulan Liu in Innate Immunity</p
Supplemental Material1 - Supplemental material for Long non-coding RNA profiling in LPS-induced intestinal inflammation model: New insight into pathogenesis
No full textSupplemental material, Supplemental Material1 for Long non-coding RNA profiling in LPS-induced intestinal inflammation model: New insight into pathogenesis by Ling Guo, Linna Li, Yang Zhang, Shulin Fu, Jing Zhang, Xiuying Wang, Huiling Zhu, Mu Qiao, Lingying Wu and Yulan Liu in Innate Immunity</p
The sense of Chengdu: embodied heritage in tastescape
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Previous issue date: 2016-07-22Embargo set by: Seth Robbins for item 95396
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Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system"Chengdu is famous for its Sichuan Cuisine with its unique spicy flavor. From the sources distributed and transported to local restaurants, then prepared, served, and eventually eaten by consumers, food is a significant part of Chengdu's culture. Eating is not only just about the food itself, but also about where to eat, how to eat, when to eat, whom to eat with. Culinary heritage is proposed to be conserved through the concept of ""tastescape"", which is planned as a combination of landscape and culture in which eating becomes a situated event. The design study focuses on the streets in historic neighborhoods in the inner city of Chengdu. The relationship between food, landscape and culture, and tastescape is proposed by combining eating with participating in theaters, local artworks, and cooking."Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2018-08-01The student, Linna Yi, accepted the attached license on 2016-07-21 at 14:46.The student, Linna Yi, submitted this Thesis for approval on 2016-07-21 at 15:13.This Thesis was approved for publication on 2016-07-22 at 09:52.DSpace SAF Submission Ingestion Package generated from Vireo submission #10042 on 2016-11-10 at 12:27:36Embargo set by: Seth Robbins for item 95396
Lift date: 2018-11-10T18:37:47Z
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Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 95396 on 2018-11-11T10:15:32Z
The role of corporate social responsibility in design of eco-friendly changes in consumer behaviour through it
No full textMagistritöö
Linna- ja tööstusmaastike korralduse õppekavalOlulise keskkonda saastava probleemina näeb autor tänapäeval ühekordsete toidunõude
massilist tarvitamist toitlustuses. Ühekordne pakend, olenemata materjalist on siiski
ühekordne ressursi kasutus. Sooviga asendada ühekordsete toidukarpide kasutamine
toitlustuses, korduvkasutatavate karpide ringlusega, on kirjutatud ka valminud töö.
Magistritöö eesmärgiks on välja selgitada tarbija valmidust muuta oma
käitumisharjumusi ja ettevõtete poolset valmidust keskkonnasäästlikumate lahenduste
loomisel.
Metoodika valikul ja küsimuste koostamisel lähtus autor vajadusest kaardistada nii
tarbijapoolne nägemus kui ka ettevõtte poolt pakutav lahendus. Sellest tingituna
kombineeris autor kvantitatiivse struktureeritud küsitluse tarbijatele, millele järgnes
poolstruktureeritud süvaintervjuu ettevõttega Topsiring ning lisaks ka struktureeritud eposti teel läbi viidud intervjuu ettevõttega Wolt.
Kokku vastas tarbijale suunatud küsimustikule 306 isikut. Küsimustiku ning intervjuude
tulemustest oli võimalik järeldada tarbija valmidust kasutada alternatiivi kui see on tema
jaoks mugav ja ei tekita talle liialt lisakohustusi. Murekohana võib siiski välja tuua, et
keskkonnasäästlikum lahendus on tihtipeale kallim kui laialt levinud ühekordne pakend.
Teine oluline mõtlemiskoht on inimeste teadlikkus alternatiivist. Ligi 50% vastanuist
eelistavad biolagunevat pakendit. Nagu töö teoreetilises osas märgitud, pole see aga
mitte kõige keskkonnasõbralikum variant. Siinkohal peab autor just oluliseks tarbija
teadlikkuse tõstmist ühekordse ressursi kasutamisel. Toetudes nii teoreetilisele osale
tööst, kui ka läbiviidud uurimusele leiab töö autor, et ühekordsete toidukarpideAuthor sees massive usage of single-use packages as an important problem as it is
polluting environment. Single-use package despite the material, is still single use resource.
Wishing to replace single-use food containers in take-out food industry, has author written
this thesis.
The purpose for these thesis is to figure out the consumer readiness to choose
environmentally friendly alternative and the role of corporate social responsibility in
designing the product.
As choosing the method and questions author proceeded from the need to map the
consumers point of view as well the alternative provided by company. According the
necessary input, author combined the quantitative questionnaire towards consumers and
structured interviews with companies Topsiring and Wolt.
Survey gathered 306 responses. The results from questionnaire and interviews indicates
consumer willingness to choose the better alternative in case if it is convenient and
acceptable. One concern to be noted, is that alternative option may often be more
expensive than widely uses single-use option. Second important note is the overall
knowledge and awareness about environmentally friendly alternatives. About 50% of
consumers prefer biodegradable single use packaging. Like mentioned in the theoretical
part of these thesis, biodegradable option is not the most eco friendly alternative.
Therefore author considered it to be important to raise the consumers awareness in singleuse resource use. Based on the theoretical part of the thesis and the results of the survey,
author sees the possibility to use reusable food containers as circular economy business
model to replace the single-use containers
Regulation of Drosophila Myc transcription by the single stranded DNA/RNA binding proteins Psi and AGO1
No full text© 2019 Dr. Linna GuoMYC has wide-ranging functions, with potential to amplify transcriptional output to activate cell growth, metabolism and cell cycle progression, thus driving oncogenic programs. As even small increases in MYC abundance are sufficient to drive the proliferative cell growth fundamental to tumour progression, understanding the molecular mechanisms controlling MYC expression will provide insight into mechanisms of MYC dysregulation in cancer. In mammalian in vitro and ex vivo systems, the KH domain single stranded DNA/RNA binding protein FUBP1 binds the Far Upstream Sequence Element (FUSE) in the activated MYC promoter to modulate transcription. Using genetic models, this thesis demonstrates that the sole FUBP family member in Drosophila, Psi, is essential for Myc transcription, cell and tissue growth in the wing epithelium, in vivo. Psi is not only required to maintain endogenous levels of Myc mRNA abundance, but depletion results in a significant increase in RNA Pol II activity on the Myc gene. Consistent with Psi regulating Myc at the level of transcription, we demonstrate Psi interacts physically and genetically with the transcriptional Mediator complex (MED), thus providing a mechanism for integration of developmental signals for patterning Myc transcription, cell and tissue growth in the wing imaginal disc epithelium.
We further report physical and genetic interaction between Psi and AGO1, the RNA binding protein component of the RNA-induced silencing complex (RISC). AGO1 loss-of-function mutations restored growth in the Psi knockdown wing, suggesting negative roles for AGO1 in Psi-dependent cell and tissue growth. AGO1 depletion was not only sufficient to increase Myc mRNA and protein abundance in the wing, but also increased Myc function i.e. transcriptional activity as measured by increased abundance of Myc targets required for ribosome biogenesis and cell growth (e.g. Ribosomal Proteins, rRNA and RNA Pol I subunits). Myc knockdown returned AGO1-depleted nucleolar compartments to the normal range, demonstrating dependency of increased growth on Myc i.e. rather than direct effects of AGO1 on ribosomal components. Interestingly, the following observations suggest AGO1 represses Myc at the level of transcription: 1) significant AGO1 enrichment on Myc promoter by ChIP, 2) physical interaction between AGO1 and MED, and 3) that AGO1 depletion activates the Myc promoter and the increased Myc mRNA requires RNA Pol II transcriptional activity. Together, these observations suggest a novel role for AGO1 as a transcriptional repressor of Myc, which underlies the tumour suppressor behaviour observed for AGO1 in the Drosophila wing
The effects of corn silk on glycaemic metabolism
No full textBackground: Corn silk contains proteins, vitamins, carbohydrates, Ca, K, Mg and Na salts, fixed and volatile oils, steroids such as sitosterol and stigmasterol, alkaloids, saponins, tannins, and flavonoids. Base on folk remedies, corn silk has been used as an oral antidiabetic agent in China for decades. However, the hypoglycemic activity of it has not yet been understood in terms of modern pharmacological concepts. The purpose of this study is to investigate the effects of corn silk on glycaemic metabolism. Methods: Alloxan and adrenalin induced hyperglycemic mice were used in the study. The effects of corn silk on blood glucose, glycohemoglobin (HbA1c), insulin secretion, damaged pancreatic beta-cells, hepatic glycogen and gluconeogenesis in hyperglycemic mice were studied respectively. Results: After the mice were orally administered with corn silk extract, the blood glucose and the HbA1c were significantly decreased in alloxan-induced hyperglycemic mice (p 0.05). Although corn silk extract increased the level of hepatic glycogen in the alloxan-induced hyperglycemic mice, there was no significant difference between them and that of the control group(p > 0.05). Conclusion: Corn silk extract markedly reduced hyperglycemia in alloxan-induced diabetic mice. The action of corn silk extract on glycaemic metabolism is not via increasing glycogen and inhibiting gluconeogenesis but through increasing insulin level as well as recovering the injured beta-cells. The results suggest that corn silk extract may be used as a hypoglycemic food or medicine for hyperglycemic people in terms of this modern pharmacological study.Background: Corn silk contains proteins, vitamins, carbohydrates, Ca, K, Mg and Na salts, fixed and volatile oils, steroids such as sitosterol and stigmasterol, alkaloids, saponins, tannins, and flavonoids. Base on folk remedies, corn silk has been used as an oral antidiabetic agent in China for decades. However, the hypoglycemic activity of it has not yet been understood in terms of modern pharmacological concepts. The purpose of this study is to investigate the effects of corn silk on glycaemic metabolism
Telicota besta subsp. besta Evans 1949
No full text107. <i>Telicota besta besta</i> Evans, 1949 <p> <i>Telicota linna besta</i>: Zhang 1997: 6 (Nanning).</p> <p> <i>Telicota linna besta</i>: Chou 1994: 743 (Guangxi).</p> <p> <i>Telicota besta besta</i>: Yuan <i>et al</i>. 2015: 616 (Guangxi).</p> <p> <b>Distribution in Guangxi.</b> Nanning.</p> <p> <b>Note.</b> <i>Telicota linna besta</i> was treated as a full species with 3 other subspecies by Eliot (1967: 153).</p>Published as part of <i>Xue, Guo-Xi, Sun, Hao, Sun, Zhou & Wang, Shao-Neng, 2016, A preliminary checklist of the skippers (Rhopalocera: Hesperiidae) of Guangxi, China, pp. 311-334 in Zootaxa 4147 (3)</i> on page 328, DOI: 10.11646/zootaxa.4147.3.5, <a href="http://zenodo.org/record/265081">http://zenodo.org/record/265081</a>
Early Preschool-Age Children Speech Development through Plays in Nature
No full textKvalifikācijas darba tēma ir Agrīnā pirmsskolas vecuma bērnu runas pilnveide rotaļās dabā. Darba autors: Linna Maderniece Darba vadītājs: Anita Ieriķe Pētnieciskā darba mērķis ir uzlabot teorijā un praksē bērnu runas pilnveidi, izmantojot pedagoģiskajā procesā rotaļas, sarunas pastaigas laikā dabā. Pētījuma mērķa sasniegšanai ir veikti sekojoši uzdevumi: 1.analizēt teorētisko literatūru kvalifikācijas darba temata jomā, 2.izpētīt bērnu runas attīstības līmeni 1.6 – 3 gadu vecumā, 3.pilnveidot bērnu runu agrīnā vecumposmā ar rotaļnodarbībām dabā, 4.analizēt un apstrādāt iegūtos rezultātus, 5.veikt secinājumus. Kvalifikācijas darbs sastāv no divām daļām, teorētiskās un praktiskās (empīriskās) daļas. Teorētiskajā daļā tika aplūkoti vairāku autoru skaidrojumi par valodas un runas funkcijām un nozīmi bērnu attīstībā. Tika aplūkoti arī vairāku autoru skaidrojumi par rotaļas un dabas nozīmi bērna attīstībā, vai rotaļas dabā var pilnveidot un attīstīt bērna runu. Empīriskajā daļā tika veikts pētījums, kurā piedalījās agrīnā pirmsskolas vecuma bērni. Tika veikta pētāmās grupas analīze un pētījuma metodoloģijas izstrāde. Tad tika apkopoti pētījuma sākotnēji iegūtie rezultāti un veikta analīze, kā rezultātā tika noskaidrots, cik efektīvi ir iespējams attīstīt bērna valodu un pilnveidot runu, rotaļās ejot ikdienas pastaigā dabā. Praktiskās daļas beigās tika apkopoti un analizēti pētījuma rezultāti. Atslēgas vārdi: runa, runas pilnveide, valodas attīstība, agrīnā pirmsskolas vecuma bērni, rotaļa, daba. Kvalifikācijas darba apjoms ir 44 lpp, tas satur 5 attēlus, 10 tabulas, tika izmantoti 43 literatūras avoti.The theme of the qualification paper is Early Preschool-Age Children Speech Development through Plays in Nature. Author: Linna Maderniece Supervisor: Anita Ierike The research aims to improve children’s speech in theory and practice through play, conversation in the pedagogical process in nature. The following tasks have been accomplished to achieve the aim of the research: 1. to analyze theoretical literature in the field of qualification paper, 2. to study the level of speech development of children aged 1.6 - 3 years, 3. to improve children’s speech at an early age with outdoor play activities, 4. to analyze and process the obtained results, 5. to draw conclusions. The qualification work consists of two parts, theoretical and practical (empirical) parts. In the theoretical part, the author explained the functions of language and speech and their significance in the development of children. The explanations of several authors on the role of play and nature in the development of the child were also considered, whether the play can improve and develop the child’s speech while playing in nature. In the empirical part, a study was conducted with early preschoolers. The study group was analyzed, and the research methodology was developed. This was followed by a summary of the initial findings of the study and an analysis of how effective it is to develop a child’s language and improve speech through play in the walks and the outdoors. At the end of the practical part, the results of the research were summarized and analyzed. Keywords: speech, speech development, language development, early preschool-age children, play, nature. The volume of the qualification paper is 44 pages, it contains 5 pictures, 10 tables, 43 sources of reference were used
The biosynthesis and discovery of lanthipeptides
No full textNatural products and their derivatives have been significant resources for the development of therapeutic compounds. They attracted interests from both academia and industry because of their high structural diversity and potential applications. Lanthipeptides are one class of natural products that have provided antibiotics to the food industry and drug candidates for treating human diseases. Lanthipeptides are polypeptides enzymatically decorated with lanthionine rings and sometimes other post-translational modifications, which dramatically elevate their protease-resistances, improved their chemical stabilities, and increased their structural complexity. To add onto the structure knowledge and biosynthetic toolkits for lanthipeptides, I investigated the biosynthesis and discovery of lanthipeptides during my Ph.D training. Duramycin/cinnamycin-type of lanthipeptides interact tightly with phosphatidylethanolamine and several of their members displayed high potential to be drug candidates. Duramycin contains an activity-essential lysinoalanine ring which is installed by a previously unknown hypothetical protein, DurN. In Chapter 2, I described the mechanism of action studies on DurN. I reconstituted the in vitro activity of DurN. Together with Dr. Cogan, we obtained the co-crystal structures of DurN with its product or substrate analog. We demonstrated that DurN catalyzes the lysinoalanine formation through a unique substrate-assisted catalysis mechanism. Enlightened by the biosynthesis of lanthipeptide, I further designed and initiated a proof-of-concept lanthipeptide discovery project based on the predictions for the potential mode of action of natural products, which is described in Chapter 3. I hypothesized that if the gene encoding a small molecule-processing enzyme locates in the biosynthetic gene cluster of a natural product on the bacterial genome, this processing enzyme may function as the immunity protein to prevent producer viability loss during the production of the natural products, and the natural product may target the small molecule. Following this hypothesis, I identified multiple lanthipeptide biosynthesis gene cluster candidates, and selected kib cluster from Kibdelsporangium phytohabitant KLBMP 1111T for verification. The lanthipeptide was produced in heterologous expression system and displayed an interlocking ring topology with a succinimide moiety as potential warhead. The activity assays of this new lanthipeptide will be carried out in the future studies. To further understand the modes of action for lanthipeptides, in Chapter 4, I investigated the mode of action of lipid II-targeting lanthipeptides. The binding event between nisin–lipid II and Halα–lipid II were characterized using isothermal titration calorimetry. Collectively, these studies further expanded our knowledge on lanthipeptides biosynthesis and discovery.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2021-12-01The student, Linna An, accepted the attached license on 2019-11-25 at 20:07.The student, Linna An, submitted this Dissertation for approval on 2019-11-25 at 21:50.This Dissertation was approved for publication on 2019-11-26 at 15:32.DSpace SAF Submission Ingestion Package generated from Vireo submission #14619 on 2020-02-28 at 17:22:48Made available in DSpace on 2020-03-02T22:15:02Z (GMT). No. of bitstreams: 5
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Previous issue date: 2019-11-26Embargo set by: Seth Robbins for item 113898
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Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 113898
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Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 113898 on 2022-03-03T10:15:25Z
Alleede süsteemi potentsiaal Vietnami linnade aianduse arendamisele Ho Chi Minhi linna näite
No full textMaster’s thesis
Curriculum in Landscape ArchitectureThe world has to face serious globalization, rapid urbanization, population growth, energy
expenditures, food insecurity, and global climate change processes. Besides, Vietnam and especially
Ho Chi Minh city, is facing these global impacts. At the same time, it also faces internal issues such
as lack of open and accessible public spaces, greenery, healthy food, and community spirit and identity
loss. The study aims to find the potential for urban food growing by restoring and establishing a new
green and community spaces in the alley system of Ho Chi Minh city. The data and the methodology
will be divided into three sections What, Why, and How with six steps. Each step will use some
suitable methods to manage, examine data, and get the results. Because of the differences in steps,
several suitable methodologies would be introduced into each step. The study provides new insight
into the relationship between urban agriculture and "cultural landscape." The author could say that
urban agriculture or community garden is a good example of a "cultural landscape," or it is a "cultural
landscape." Besides, it could be confirmed that food and urban agriculture or community garden on a
small scale do not solve many global issues. To solve a global issue as food shortages or insecurity on
a large scale, urban agriculture itself cannot help to deal with; it needs to connect with rural food
growing and many different sectors. Food is not the main issue that needs to be solved in this study.
However, it is critical not only to create community spaces but also to bring back the places' spirits,
values, and identities.Maailm peab silmitsi seisma tõsise globaliseerumise, kiire linnastumise, rahvastiku kasvu,
energiakulu, toidupuuduse ja globaalsete kliimamuutuste protsessidega. Vietnam ja eriti Ho Chi
Minhi linn seisab nende globaalsete mõjude ees. Samal ajal ollakse vastamisi siseprobleemidega,
milleks on: avatud ja ligipääsetavate avalike ruumide puudumine, rohelus, tervislik toit ning
kogukonna vaimu ja identiteedikadu. Uuringu eesmärk on leida võimalused linnas toidu
kasvatamiseks, läbi uute rohe- ja kogukonnaruumide rajamise alleede süsteemis Ho Chi Minhi
linnas. Uuringu eesmärk on leida linnatoidu kasvatamise potentsiaal, taastades ning rajades uusi
roheruume ja kogukondlike ruume Ho Chi Mingi alleede süsteemides. Uuringu andmestik ja
metoodika jagatakse kolme jaotisse: Mis, Miks ja Kuidas kuue etapiga. Iga etapp kasutab andmete
haldamiseks, uurimiseks ja tulemuste saamiseks selleks vajalikku meetodit. Uuring annab uue
ülevaate linna agrikultuuri ja „kultuurmaastiku” vahelisest suhtest. Autor toob välja, et linna
agrikultuur või kogukondlik aed kuulub "kultuurmaastikku" või on selle hea näide. Võib kinnitada,
et toidu ja linna agrikultuur või kogukondlik aed väikeses ulatuses ei lahenda paljusid globaalseid
küsimusi. Selleks, et lahendada globaalseid probleeme, mis tulenevad toidu puudusest või
erinevatest teistest ebakindlustest suuremas mastaabis, ei saa linna agrikultuur seda üksi käsitleda,
vaid peab olema ühendatud maapiirkondade toidukasvatusega ning paljude teiste erinevate
sektoritega. Toit ei ole peamine probleem, mis tuleb selles uuringus lahendada. Siiski on oluline
mitte ainult luua ühiskondlikke ruume, vaid ka taastada kohtade hingelisus, väärtused ja identiteet
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