170,845 research outputs found
Physical aspects of cancer invasion
Get PDFInvasiveness, one of the hallmarks of tumor progression, represents the tumor's ability to expand into the host tissue by means of several complex biochemical and biomechanical processes. Since certain aspects of the problem present a striking resemblance with well-known physical mechanisms, such as the mechanical insertion of a solid inclusion in an elastic material specimen (G Eaves 1973 The invasive growth of malignant tumours as a purely mechanical process J. Pathol. 109 233; C Guiot, N Pugno and P P Delsanto 2006 Elastomechanical model of tumor invasion Appl. Phys. Lett. 89 233901) or a water drop impinging on a surface (C Guiot, P P Delsanto and T S Deisboeck 2007 Morphological instability and cancer invasion: a 'splashing water drop' analogy Theor. Biol. Med. Model 4 4), we propose here an analogy between these physical processes and a cancer system's invasive branching into the surrounding tissue. Accounting for its solid and viscous properties, we then arrive, as a unifying model, to an analogy with a granular solid. While our model has been explicitly formulated for multicellular tumor spheroids in vitro, it should also contribute to a better understanding of tumor invasion in vivo
CRITICAL-BEHAVIOR IN RANDOM FIELD GAUGE-THEORY
No full textGUIOT C, KEHL E, Satz H, WALTL B. CRITICAL-BEHAVIOR IN RANDOM FIELD GAUGE-THEORY. ZEITSCHRIFT FUR PHYSIK C-PARTICLES AND FIELDS. 1988;38(3):495-499
Computer simulations and modeling in oncology: Methods and applications
No full textComputational models and simulations can be powerful tools for gaining an insight into the extremely complex mechanisms governing tumoral growth. In order to be relied upon, however, they must be validated by comparison with sufficiently long strings of experimental or observational data. For obvious ethical reasons it is virtually impossible to obtain such data "in vivo". It may be, therefore, expedient to study the growth of tumoral lines "in vitro" or "ex vivo", i.e. by transplanting them into lab animals (e.g., mice). In fact, experiments with as many as 900 successive transplants into new healthy mice have been performed. Using a recently proposed technique for the analysis of experimental datasets (the Phenomenological Universalities Approach), we have succeeded to reproduce, to an excellent level of reliability, the results of such "multipassage" growth and to explain quantitatively why the growth curves become progressively steeper at each new transplant. We believe that our method could also be applied to study metastatic diffusion and suggest new experiments to further validate our approach and result
A Classification Scheme for Phenomenological Universalities in Growth Problems in Physics and Other Sciences,
No full text
Recommended from our members
Morphological instability and cancer invasion: a "splashing water drop" analogy
Get PDFBACKGROUND: Tissue invasion, one of the hallmarks of cancer, is a major clinical problem. Recent studies suggest that the process of invasion is driven at least in part by a set of physical forces that may be susceptible to mathematical modelling which could have practical clinical value. MODEL AND CONCLUSION: We present an analogy between two unrelated instabilities. One is caused by the impact of a drop of water on a solid surface while the other concerns a tumor that develops invasive cellular branches into the surrounding host tissue. In spite of the apparent abstractness of the idea, it yields a very practical result, i.e. an index that predicts tumor invasion based on a few measurable parameters. We discuss its application in the context of experimental data and suggest potential clinical implication
- …
