1,721,007 research outputs found
Gene manipulation and improvement of athletic performances: new strategies in blood doping.
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Molar expression: Interconverting results of highly sensitive troponin I and T while preserving clinical significance.
No full textMolar expression: Interconverting results of highly sensitive troponin I and T while preserving clinical significance
Relationship between mean platelet volume and biochemical components of the metabolic syndrome.
No full textLipoprotein[a] and cancer: antineoplastic effect besides its cardiovascular potency.
No full textWhile the death rate from cancer has substantially decreased over the past decade, the search for effective and tolerable therapies is a great challenge as yet. The evidence that malignant cells cannot grow to a clinically detectable tumor mass and spread in the absence of an adequate vascular support, has opened a new area of research towards the selective inhibition or even destruction of tumor vessels. Angiostatin and angiostatin-related proteins are a family of specific angiogenesis inhibitors produced by tumors from a family of naturally occurring proteins, which also includes plasminogen and lipoprotein[a]. The anti-angiogenic activity of these proteins resides in cryptic and highly-repetitive molecular domains hidden within the protein moiety, called kringles. Lipoprotein[a] is an intriguing molecule consisting of a low-density lipoprotein core in addition to the covalently bound apolipoprotein[a]. Apolipoprotein[a] is characterized by an inactive protease domain, a single copy of the plasminogen kringle V and multiple repeats of domains homologous to the plasminogen kringle IV. Reliable studies on animal models indicate that the proteolytic break-down products of apolipoprotein[a] would posses anti-angiogenic and anti-tumoral properties both in vitro and in vivo, a premise to develop novel therapeutic modalities which may efficiently suppress tumor growth and metastasis. This review is focused on the biochemical structure, metabolism and the anti-angiogenic activity of this unique and elusive kringle-containing lipoprotein. © 2007 Elsevier Ltd. All rights reserved
Relationship between serum vitamin D and inflammatory markers in the general population: comment on the article by Patel et al.
No full textInfluence of two different buffered sodium citrate concentrations on coagulation testing.
No full textStandards of practice and uniformity in references style
No full textAuthors are usually invited to follow the instructions to authors in scientific journals, because this section is likely to contain unique requirements, such as the references style requested. Authors not only must accurately check the instructions, but are also expected to verify references against the original documents before submitting the article, consuming a considerable amount of time. This aspect may contribute to the large number of references errors in scientific manuscripts, some of which would be prevented by introducing a more homogeneous and uniformed style. A variety of international, peer-reviewed journals currently requires a rather different style, especially for the numbers of authors to be cited, the placing of the year of publication, the style of the journal title. A broad implementation of reasonable standards of practice and consensus guidelines for the format of manuscript references should be promoted for an advantageous process for both the journals and the a..
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